2.1.2.1: glycine hydroxymethyltransferase
This is an abbreviated version!
For detailed information about glycine hydroxymethyltransferase, go to the full flat file.
Word Map on EC 2.1.2.1
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2.1.2.1
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one-carbon
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pyridoxal
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thymidylate
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purine
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5'-phosphate
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homocysteine
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dihydrofolate
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folate-dependent
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photorespiratory
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photorespiration
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folate-mediated
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pyridoxal-5'-phosphate
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thf
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dtmp
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mthfd1
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plp-dependent
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remethylation
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aldimine
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phgdh
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medicine
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folate-metabolizing
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5,10-methenyltetrahydrofolate
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5'-phosphate-dependent
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antifolate
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hydroxypyruvate
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quinonoid
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5-methyltetrahydrofolate
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glycerate
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5-formyltetrahydrofolate
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drug development
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folate-related
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d-alanine
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c1-tetrahydrofolate
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1-carbon
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5-formyl
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polyglutamate
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l-threonine
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alpha-protons
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slc19a1
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retro-aldol
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degradation
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analysis
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synthesis
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biotechnology
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pharmacology
- 2.1.2.1
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one-carbon
- pyridoxal
- thymidylate
- purine
- 5'-phosphate
- homocysteine
- dihydrofolate
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folate-dependent
-
photorespiratory
-
photorespiration
-
folate-mediated
- pyridoxal-5'-phosphate
- thf
- dtmp
- mthfd1
-
plp-dependent
-
remethylation
-
aldimine
- phgdh
- medicine
-
folate-metabolizing
- 5,10-methenyltetrahydrofolate
-
5'-phosphate-dependent
- antifolate
- hydroxypyruvate
-
quinonoid
- 5-methyltetrahydrofolate
- glycerate
- 5-formyltetrahydrofolate
- drug development
-
folate-related
- d-alanine
-
c1-tetrahydrofolate
-
1-carbon
-
5-formyl
- polyglutamate
- l-threonine
-
alpha-protons
-
slc19a1
-
retro-aldol
- degradation
- analysis
- synthesis
- biotechnology
- pharmacology
Reaction
Synonyms
AtSHMT3, bsSHMT, bstSHMT, EC 4.1.2.6, eSHMT, GlyA, GlyA protein, glycine hydroxymethyltransferrase, hSHMT, L-serine hydroxymethyltransferase, mitochondrial serine hydroxymethyltransferase, MJ1597, PvSHMT, Rhg4, serine hydroxymethyl transferase, serine hydroxymethylase hydroxymethyltransferase, serine, serine hydroxymethyltransferase, serine hydroxymethyltransferase 1, serine hydroxymethyltransferase 2, serine hydroxymethyltransferase 2alpha, serine transhydroxymethylase, serine:H4F hydroxymethyltransferase, serine:tetrahydrofolate hydroxymethyltransferase, SHM1, SHM2, SHMT, SHMT-1, SHMT-L, SHMT-S, SHMT08, SHMT1, SHMT2, SHMT2alpha, SHMT3, zcSHMT, zebrafish cytosolic serine hydroxymethyltransferase, zebrafish mitochondiral serine hydroxymethyltransferase, zmSHMT
ECTree
2.1.2.1 glycine hydroxymethyltransferaseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 2.1.2.1 - glycine hydroxymethyltransferase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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expression patterns of SHMT2 in 76 breast cancer patients after modified radical mastectomy, immunohistochemic analysis, SHMT2 is highly expressed in breast cancer cells, and the expression level of SHMT2 is positively correlated with breast cancer grade
in human glioblastoma multiforme, mitochondrial serine hydroxymethyltransferase (SHMT2) and glycine decarboxylase are highly expressed in the pseudopalisading cells that surround necrotic foci
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both PfSHMTc and PfSHMTm are concentrated in the central region of the parasite that becomes the residual body on erythrocyte lysis and merozoite release
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early trophozoites lack visible organellar isozyme PfSHMTc, while it occurs during the mid-to-late trophozoite and schizont stages
additional information
in healthy brains, SHMT2 expression is not detected in most cells but is at low levels in astrocytes and vessels
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SHMT activity of antisense lines is 70-90% lower than in the wild-type, negative effects of antisensed SHMT becomes increasingly severe with plant age
elevated mRNA expression detected by RT-PCT. Strong protein expression detected by western blotting
siginificant protein expression detected by Western Blotting only in liver and ovary
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from rats fed dietary pyridoxine ranging from adequare to deficient levels, 2-0 mg pyridoxine per kg diet
elevated mRNA expression detected by RT-PCT. Strong protein expression detected by western blotting
siginificant protein expression detected by Western Blotting only in liver and ovary
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low activity, activity is similar 8 weeks post conception and at term
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activity per gram of placenta increases 2.1fold between midgestation and term
additional information
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cellular distribution of SHM1 and SHM2, detailed overview
additional information
RT-PCR results show that zmSHMT mRNA is evenly distributed among tissues. However zmSHMT protein expression does not correspond to the detected mRNA expression detected in most tissues
additional information
RT-PCR results show that zmSHMT mRNA is evenly distributed among tissues. However zmSHMT protein expression does not correspond to the detected mRNA expression detected in most tissues
additional information
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RT-PCR results show that zmSHMT mRNA is evenly distributed among tissues. However zmSHMT protein expression does not correspond to the detected mRNA expression detected in most tissues
additional information
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SHMT2alpha co-localizes with lamin B1 in SH-SY5Y cells. Recombinant dominant negative SHMT1, DN2-SHMT1, localizes with lamin B1 and enhances SHMT1 activity for de novo thymidylate biosynthesis
additional information
gene is preferentially expressed in the amastigote stage of parasite
additional information
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gene is preferentially expressed in the amastigote stage of parasite
additional information
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gene is preferentially expressed in the amastigote stage of parasite
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