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2.1.2.1: glycine hydroxymethyltransferase

This is an abbreviated version!
For detailed information about glycine hydroxymethyltransferase, go to the full flat file.

Word Map on EC 2.1.2.1

Reaction

5,10-methylenetetrahydrofolate
+
glycine
 +
H2O
=
tetrahydrofolate
 +
L-serine

Synonyms

AtSHMT3, bsSHMT, bstSHMT, EC 4.1.2.6, eSHMT, GlyA, GlyA protein, glycine hydroxymethyltransferrase, hSHMT, L-serine hydroxymethyltransferase, mitochondrial serine hydroxymethyltransferase, MJ1597, PvSHMT, Rhg4, serine hydroxymethyl transferase, serine hydroxymethylase hydroxymethyltransferase, serine, serine hydroxymethyltransferase, serine hydroxymethyltransferase 1, serine hydroxymethyltransferase 2, serine hydroxymethyltransferase 2alpha, serine transhydroxymethylase, serine:H4F hydroxymethyltransferase, serine:tetrahydrofolate hydroxymethyltransferase, SHM1, SHM2, SHMT, SHMT-1, SHMT-L, SHMT-S, SHMT08, SHMT1, SHMT2, SHMT2alpha, SHMT3, zcSHMT, zebrafish cytosolic serine hydroxymethyltransferase, zebrafish mitochondiral serine hydroxymethyltransferase, zmSHMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.2 Hydroxymethyl-, formyl- and related transferases
                2.1.2.1 glycine hydroxymethyltransferase

Specific Activity

Specific Activity on EC 2.1.2.1 - glycine hydroxymethyltransferase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.012
-
mutant enzyme E74Q
0.02
-
crude extract
0.0385
-
in the presence of glycine, in 200 mM HEPES buffer, pH 7.0
0.048
-
reaction of L-serine
0.05
-
mutant enzyme Y61A, using L-serine as substrate, at 37°C
0.15
-
reaction of L-threonine
0.5
pH 7.2, 37°C, extract from Escherichia coli cells carrying the expression vector
0.52
-
mutant enzyme
1.388
-
reaction of L-allothreonine
1.86
-
after 3.8fold purification, in 50 mM HEPES (pH 7.0), 1 mM dithiothreitol and 0.5 mM EDTA at 25°C
11.9
-
-
15.5
-
mitochondria
3.2
-
purified recombinant enzyme
32.4
-
dimeric form at 80°C
4.1
-
only tetrameric form
4.8
-
-
5
-
wild type enzyme, using L-serine as substrate, at 37°C
5.46
purified enzyme
6.7
-
only dimeric form
7.9
-
serine synthesis
additional information