2.1.2.1: glycine hydroxymethyltransferase
This is an abbreviated version!
For detailed information about glycine hydroxymethyltransferase, go to the full flat file.
Word Map on EC 2.1.2.1
-
2.1.2.1
-
one-carbon
-
pyridoxal
-
thymidylate
-
purine
-
5'-phosphate
-
homocysteine
-
dihydrofolate
-
folate-dependent
-
photorespiratory
-
photorespiration
-
folate-mediated
-
pyridoxal-5'-phosphate
-
thf
-
dtmp
-
mthfd1
-
plp-dependent
-
remethylation
-
aldimine
-
phgdh
-
medicine
-
folate-metabolizing
-
5,10-methenyltetrahydrofolate
-
5'-phosphate-dependent
-
antifolate
-
hydroxypyruvate
-
quinonoid
-
5-methyltetrahydrofolate
-
glycerate
-
5-formyltetrahydrofolate
-
drug development
-
folate-related
-
d-alanine
-
c1-tetrahydrofolate
-
1-carbon
-
5-formyl
-
polyglutamate
-
l-threonine
-
alpha-protons
-
slc19a1
-
retro-aldol
-
degradation
-
analysis
-
synthesis
-
biotechnology
-
pharmacology
- 2.1.2.1
-
one-carbon
- pyridoxal
- thymidylate
- purine
- 5'-phosphate
- homocysteine
- dihydrofolate
-
folate-dependent
-
photorespiratory
-
photorespiration
-
folate-mediated
- pyridoxal-5'-phosphate
- thf
- dtmp
- mthfd1
-
plp-dependent
-
remethylation
-
aldimine
- phgdh
- medicine
-
folate-metabolizing
- 5,10-methenyltetrahydrofolate
-
5'-phosphate-dependent
- antifolate
- hydroxypyruvate
-
quinonoid
- 5-methyltetrahydrofolate
- glycerate
- 5-formyltetrahydrofolate
- drug development
-
folate-related
- d-alanine
-
c1-tetrahydrofolate
-
1-carbon
-
5-formyl
- polyglutamate
- l-threonine
-
alpha-protons
-
slc19a1
-
retro-aldol
- degradation
- analysis
- synthesis
- biotechnology
- pharmacology
Reaction
Synonyms
AtSHMT3, bsSHMT, bstSHMT, EC 4.1.2.6, eSHMT, GlyA, GlyA protein, glycine hydroxymethyltransferrase, hSHMT, L-serine hydroxymethyltransferase, mitochondrial serine hydroxymethyltransferase, MJ1597, PvSHMT, Rhg4, serine hydroxymethyl transferase, serine hydroxymethylase hydroxymethyltransferase, serine, serine hydroxymethyltransferase, serine hydroxymethyltransferase 1, serine hydroxymethyltransferase 2, serine hydroxymethyltransferase 2alpha, serine transhydroxymethylase, serine:H4F hydroxymethyltransferase, serine:tetrahydrofolate hydroxymethyltransferase, SHM1, SHM2, SHMT, SHMT-1, SHMT-L, SHMT-S, SHMT08, SHMT1, SHMT2, SHMT2alpha, SHMT3, zcSHMT, zebrafish cytosolic serine hydroxymethyltransferase, zebrafish mitochondiral serine hydroxymethyltransferase, zmSHMT
ECTree
2.1.2.1 glycine hydroxymethyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.1.2.1 - glycine hydroxymethyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5,10-methenyl-tetrahydropteroyl pentaglutamate + glycine + H2O
5-formyl-tetrahydropteroyl pentaglutamate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-Ser
-
the enzyme is a major source of one-carbon units for cellular metabolism. Potential for disruption of SHMT-mediated one-carbon metabolism by inadequate vitamin B-6 intake
-
-
r
5,6,7,8-tetrahydrofolate + L-Ser
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
D-alanine + (benzyloxy)acetaldehyde + H2O
(3R)-4-(benzyloxy)-3-hydroxy-L-isovaline + (3S)-4-(benzyloxy)-3-hydroxy-L-isovaline
D-alanine + 2-fluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-methylpropanoic acid + (2S,3R)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-methylpropanoic acid
D-alanine + 3-phenylpropanal + H2O
(3S)-3-hydroxy-2-methyl-5-phenyl-L-norvaline + (3R)-3-hydroxy-2-methyl-5-phenyl-L-norvaline
D-alanine + 4-(benzyloxy)butanal + H2O
(3R)-3-hydroxy-4-(3-phenylpropoxy)-L-isovaline + (3S)-3-hydroxy-4-(3-phenylpropoxy)-L-isovaline
-
-
-
?
D-alanine + 4-chlorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(4-chlorophenyl)-3-hydroxy-2-methylpropanoic acid + (2S,3R)-2-amino-3-(4-chlorophenyl)-3-hydroxy-2-methylpropanoic acid
-
-
-
?
D-alanine + 4-formylphenyl acetate + H2O
(2S,3S)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxy-2-methylpropanoic acid + (2S,3R)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxy-2-methylpropanoic acid
-
-
-
?
D-alanine + 4-hydroxybenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropanoic acid + (2S,3R)-2-amino-3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropanoic acid
-
-
-
?
D-alanine + 4-nitrobenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-methyl-3-(4-nitrophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-methyl-3-(4-nitrophenyl)propanoic acid
-
-
-
?
D-alanine + benzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-methyl-3-phenylpropanoic acid + (2S,3R)-2-amino-3-hydroxy-2-methyl-3-phenylpropanoic acid
-
-
-
?
D-alanine + benzyl (2-oxoethyl)carbamate + H2O
(3S)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-L-isovaline + (3R)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-L-isovaline
-
-
-
?
D-alanine + benzyl (3-oxopropyl)carbamate + H2O
(3S)-N6-[(benzyloxy)carbonyl]-3-hydroxy-2-methyl-L-lysine + (2S,3R)-2-amino-6-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-methylhexanoic acid
-
-
-
?
D-alanine + benzyl [(2R)-1-oxopropan-2-yl]carbamate + H2O
(3S)-N6-[(benzyloxy)carbonyl]-3-hydroxy-2-methyl-L-lysine + (3R)-N6-[(benzyloxy)carbonyl]-3-hydroxy-2-methyl-L-lysine
-
-
-
?
D-alanine + benzyl [(2S)-1-oxopropan-2-yl]carbamate + H2O
(3S,4S)-4-([(benzyloxy)carbonyl]amino)-3-hydroxy-2-methyl-L-norvaline + (3R,4S)-4-([(benzyloxy)carbonyl]amino)-3-hydroxy-2-methyl-L-norvaline
-
-
-
?
D-alanine + pentafluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-methyl-3-(pentafluorophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-methyl-3-(pentafluorophenyl)propanoic acid
-
-
-
?
D-alanine + phenoxyacetaldehyde + H2O
(3R)-3-hydroxy-4-phenoxy-L-isovaline + (3S)-3-hydroxy-4-phenoxy-L-isovaline
-
-
-
?
D-alanine + phenylacetaldehyde + H2O
(3S)-3-hydroxy-4-phenyl-L-isovaline + (3R)-3-hydroxy-4-phenyl-L-isovaline
-
-
-
?
D-serine + (benzyloxy)acetaldehyde + H2O
(3R)-4-(benzyloxy)-2',3-dihydroxy-L-isovaline + (3S)-4-(benzyloxy)-2',3-dihydroxy-L-isovaline
-
-
-
?
D-serine + 2-fluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-(hydroxymethyl)propanoic acid + (2S,3R)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-(hydroxymethyl)propanoic acid
-
-
-
?
D-serine + 3-phenylpropanal + H2O
(3S)-3-hydroxy-2-(hydroxymethyl)-5-phenyl-L-norvaline + (3R)-3-hydroxy-2-(hydroxymethyl)-5-phenyl-L-norvaline
-
-
-
?
D-serine + 4-(benzyloxy)butanal + H2O
(3S)-4-[[(benzyloxy)carbonyl]amino]-2',3-dihydroxy-L-isovaline + (3S)-2',3-dihydroxy-4-(3-phenylpropoxy)-L-isovaline
-
-
-
?
D-serine + 4-chlorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(4-chlorophenyl)-3-hydroxy-2-(hydroxymethyl)propanoic acid + (2S,3R)-2-amino-3-(4-chlorophenyl)-3-hydroxy-2-(hydroxymethyl)propanoic acid
-
-
-
?
D-serine + 4-formylphenyl acetate + H2O
(2S,3S)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxy-2-(hydroxymethyl)propanoic acid + (2S,3R)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxy-2-(hydroxymethyl)propanoic acid
-
-
-
?
D-serine + 4-hydroxybenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(4-hydroxyphenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(4-hydroxyphenyl)propanoic acid
-
-
-
?
D-serine + 4-nitrobenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(4-nitrophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(4-nitrophenyl)propanoic acid
-
-
-
?
D-serine + benzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-phenylpropanoic acid + (2S,3R)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-phenylpropanoic acid
-
-
-
?
D-serine + benzyl (2-oxoethyl)carbamate + H2O
(3S)-4-[[(benzyloxy)carbonyl]amino]-2',3-dihydroxy-L-isovaline + (3R)-4-[[(benzyloxy)carbonyl]amino]-2',3-dihydroxy-L-isovaline
-
-
-
?
D-serine + benzyl (3-oxopropyl)carbamate + H2O
(3S)-N6-[(benzyloxy)carbonyl]-3-hydroxy-2-(hydroxymethyl)-L-lysine + (3R)-N6-[(benzyloxy)carbonyl]-3-hydroxy-2-(hydroxymethyl)-L-lysine
-
-
-
?
D-serine + benzyl [(2R)-1-oxopropan-2-yl]carbamate + H2O
(3S,4R)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-(hydroxymethyl)-L-norvaline + (3R,4R)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-(hydroxymethyl)-L-norvaline
-
-
-
?
D-serine + benzyl [(2S)-1-oxopropan-2-yl]carbamate + H2O
(3S,4S)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-(hydroxymethyl)-L-norvaline + (3R,4S)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-(hydroxymethyl)-L-norvaline
-
-
-
?
D-serine + pentafluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(pentafluorophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(pentafluorophenyl)propanoic acid
-
-
-
?
D-serine + phenoxyacetaldehyde + H2O
(3R)-2',3-dihydroxy-4-phenoxy-L-isovaline + (3S)-2',3-dihydroxy-4-phenoxy-L-isovaline
-
-
-
?
D-serine + phenylacetaldehyde + H2O
(3S)-2',3-dihydroxy-4-phenyl-L-isovaline + (3R)-2',3-dihydroxy-4-phenyl-L-isovaline
-
-
-
?
glycine + (benzyloxy)acetaldehyde + H2O
(2S,3R)-2-amino-4-(benzyloxy)-3-hydroxybutanoic acid + (2S,3S)-2-amino-4-(benzyloxy)-3-hydroxybutanoic acid
-
-
-
?
glycine + 2-fluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(2-fluorophenyl)-3-hydroxypropanoic acid + (2S,3R)-2-amino-3-(2-fluorophenyl)-3-hydroxypropanoic acid
-
-
-
?
glycine + 3-phenylpropanal + H2O
(3S)-3-hydroxy-5-phenyl-L-norvaline + (3R)-3-hydroxy-5-phenyl-L-norvaline
-
-
-
?
glycine + 4-(benzyloxy)butanal + H2O
(2S,3R)-2-amino-3-hydroxy-4-(3-phenylpropoxy)butanoic acid + (2S,3S)-2-amino-3-hydroxy-4-(3-phenylpropoxy)butanoic acid
-
-
-
?
glycine + 4-chlorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(4-chlorophenyl)-3-hydroxypropanoic acid + (2S,3R)-2-amino-3-(4-chlorophenyl)-3-hydroxypropanoic acid
-
-
-
?
glycine + 4-formylphenyl acetate + H2O
(2S,3S)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxypropanoic acid + (2S,3R)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxypropanoic acid
-
-
-
?
glycine + 4-hydroxybenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-3-(4-hydroxyphenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-3-(4-hydroxyphenyl)propanoic acid
-
-
-
?
glycine + 4-nitrobenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-3-(4-nitrophenyl)propanoic acid
-
-
-
?
glycine + benzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid + (2S,3R)-2-amino-3-hydroxy-3-phenylpropanoic acid
-
-
-
?
glycine + benzyl (2-oxoethyl)carbamate + H2O
(2S,3S)-2-amino-4-[[(benzyloxy)carbonyl]amino]-3-hydroxybutanoic acid + (2S,3R)-2-amino-4-[[(benzyloxy)carbonyl]amino]-3-hydroxybutanoic acid
-
-
-
?
glycine + benzyl (3-oxopropyl)carbamate + H2O
(2S,3S)-2-amino-6-[[(benzyloxy)carbonyl]amino]-3-hydroxyhexanoic acid + (2S,3R)-2-amino-6-[[(benzyloxy)carbonyl]amino]-3-hydroxyhexanoic acid
-
-
-
?
glycine + benzyl [(2R)-1-oxopropan-2-yl]carbamate + H2O
(2S,3S,4R)-2-amino-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-methylpentanoic acid + (2S,3S,4R)-2-amino-4-[[(benzyloxy)carbonyl]amino]-3-hydroxypentanoic acid
-
-
-
?
glycine + benzyl [(2S)-1-oxopropan-2-yl]carbamate + H2O
(2S,3R,4S)-2-amino-4-[[(benzyloxy)carbonyl]amino]-3-hydroxypentanoic acid + (2S,3S,4S)-2-amino-4-[[(benzyloxy)carbonyl]amino]-3-hydroxypentanoic acid
-
-
-
?
glycine + pentafluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-3-(pentafluorophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-3-(pentafluorophenyl)propanoic acid
-
-
-
?
glycine + phenoxyacetaldehyde + H2O
(2S,3R)-2-amino-3-hydroxy-4-phenoxybutanoic acid + (2S,3S)-2-amino-3-hydroxy-4-phenoxybutanoic acid
-
-
-
?
glycine + phenylacetaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-4-phenylbutanoic acid + (2S,3R)-2-amino-3-hydroxy-4-phenylbutanoic acid
-
-
-
?
L-serine + tetrahydropteroylglutamate
glycine + 5,10-methylene-tetrahydropteroylglutamate + H2O
(6S)-tetrahydrofolate + D-serine
5,10-methylenetetrahydrofolate + glycine + H2O
poor activity
-
-
r
(6S)-tetrahydrofolate + D-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
(6S)-tetrahydrofolate + D-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
(6S)-tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
(6S)-tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
the enzyme also catalyzes the formation of methylene-tetrahydromethanopterin from tetrahydromethanopterin and L-serine, albeit with a catalytic efficiency which is less than 1% of that with (6S)-tetrahydrofolate as substrate. The catalytic efficiency with methylene-tetrahydrosarcinapterin as substrate is even lower
-
-
?
(6S)-tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
the enzyme also catalyzes the formation of methylene-tetrahydromethanopterin from tetrahydromethanopterin and L-serine, albeit with a catalytic efficiency which is less than 1% of that with (6S)-tetrahydrofolate as substrate. The catalytic efficiency with methylene-tetrahydrosarcinapterin as substrate is even lower
-
-
?
(6S)-tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
(6S)-tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
5,10-methenyl-tetrahydropteroyl pentaglutamate + glycine + H2O
5-formyl-tetrahydropteroyl pentaglutamate + L-serine
-
-
-
-
?
5,10-methenyl-tetrahydropteroyl pentaglutamate + glycine + H2O
5-formyl-tetrahydropteroyl pentaglutamate + L-serine
-
-
-
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + D-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + D-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + D-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Aedes aegypti NIH Rockefeller
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
i.e. tetrahydropteroylglutamate, tetrahydropteroylglutamates with more than one glutamate residue are poor substrates and competitive inhibitors, overview
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
tetrahydrofolate-dependent SHMT activity, modeling of substrate binding, overview
-
-
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
tetrahydrofolate-dependent SHMT activity, modeling of substrate binding, overview
-
-
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Hydrogenobacter thermophilus TK-6 / IAM 12695
-
-
-
-
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
Hydrogenobacter thermophilus TK-6 / IAM 12695
-
tetrahydrofolate-dependent SHMT activity, modeling of substrate binding, overview
-
-
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
tetrahydrofolate-dependent SHMT activity, modeling of substrate binding, overview
-
-
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
tetrahydrofolate-dependent SHMT activity, modeling of substrate binding, overview
-
-
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
?
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
-
-
-
r
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
-
-
?
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
-
-
?
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
-
-
?
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
-
-
-
?
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
-
-
-
?
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
-
-
?
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
-
-
?
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
-
-
?
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
-
-
?
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
-
-
?
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
at high concentrations of enzyme
-
?
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
-
-
?
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
-
-
?
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
-
-
?
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
-
-
-
?
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
-
-
-
?
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
-
-
-
?
D-alanine + (benzyloxy)acetaldehyde + H2O
(3R)-4-(benzyloxy)-3-hydroxy-L-isovaline + (3S)-4-(benzyloxy)-3-hydroxy-L-isovaline
-
-
-
?
D-alanine + (benzyloxy)acetaldehyde + H2O
(3R)-4-(benzyloxy)-3-hydroxy-L-isovaline + (3S)-4-(benzyloxy)-3-hydroxy-L-isovaline
-
-
-
?
D-alanine + 2-fluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-methylpropanoic acid + (2S,3R)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-methylpropanoic acid
-
-
-
?
D-alanine + 2-fluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-methylpropanoic acid + (2S,3R)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-methylpropanoic acid
-
-
-
?
D-alanine + 3-phenylpropanal + H2O
(3S)-3-hydroxy-2-methyl-5-phenyl-L-norvaline + (3R)-3-hydroxy-2-methyl-5-phenyl-L-norvaline
-
-
-
?
D-alanine + 3-phenylpropanal + H2O
(3S)-3-hydroxy-2-methyl-5-phenyl-L-norvaline + (3R)-3-hydroxy-2-methyl-5-phenyl-L-norvaline
-
-
-
?
D-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
the catalytic efficiency for D-serine is 580fold lower than that of L-serine
-
-
?
D-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
the catalytic efficiency for D-serine is 580fold lower than that of L-serine
-
-
?
D-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
the binding affinity for D-serine is 150fold lower than that of L-serine
-
-
?
L-Ser + tetrahydrofolate
Gly + 5,10-methylenetetrahydrofolate
-
-
-
-
?
L-Ser + tetrahydrofolate
Gly + 5,10-methylenetetrahydrofolate
-
-
-
?
L-Ser + tetrahydrofolate
Gly + 5,10-methylenetetrahydrofolate
-
placental conversion of serine to glycine is a major source of fetal glycine
-
-
?
L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + modified folate
glycine + modified methylenefolate
not: tetrahydrofolate, synthetic modified folate derivate
-
?
L-serine + modified folate
glycine + modified methylenefolate
not: tetrahydrofolate, synthetic modified folate derivate
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
may play important role in central nervous system
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
may play important role in central nervous system
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
major pathway for production of C1-units of 5,10-methylenetetrahydrofolate
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
major pathway for production of C1-units of 5,10-methylenetetrahydrofolate
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
catalyzes interconversion of serine and glycine
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
main glycine source for purine biosynthetic pathway in ureide biogenesis
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
main glycine source for purine biosynthetic pathway in ureide biogenesis
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
major pathway for production of C1-units of 5,10-methylenetetrahydrofolate
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
major pathway for production of C1-units of 5,10-methylenetetrahydrofolate
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
main glycine source for purine biosynthetic pathway in ureide biogenesis
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
key enzyme of serine pathway for assimilation of C1-compounds
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
key enzyme of serine pathway for assimilation of C1-compounds
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
adding 2fold more glycine in the medium increases significantly the expression of SHMT-S and to an even higher level, the expression of SHMT-L, adding 2fold more serine has the reverse effect on the expression of SHMT-L, while the expression of SHMT-S does not change significantly
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
regulatory protein
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
main glycine source for purine biosynthetic pathway in ureide biogenesis
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
key enzyme of serine pathway for assimilation of C1-compounds
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
may play important role in central nervous system
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
enzyme is a component of thymidylate cycle
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
may play important role in central nervous system
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
catalyzes interconversion of serine and glycine
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
enzyme is a component of thymidylate cycle
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
may play important role in central nervous system
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
only (6S)-tetrahydrofolate can serve as a substrate for His6-tagged SHMT, the presence of (6R)-tetrahydrofolate has no interference to the reaction
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
only (6S)-tetrahydrofolate can serve as a substrate for His6-tagged SHMT, the presence of (6R)-tetrahydrofolate has no interference to the reaction
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
L-serine is the physiological substrate
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
major pathway for production of C1-units of 5,10-methylenetetrahydrofolate
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
major pathway for production of C1-units of 5,10-methylenetetrahydrofolate
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
catalyzes interconversion of serine and glycine
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
key enzyme of serine pathway for assimilation of C1-compounds
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
key enzyme of serine pathway for assimilation of C1-compounds
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
key enzyme of serine pathway for assimilation of C1-compounds
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
key enzyme of serine pathway for assimilation of C1-compounds
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
may play important role in central nervous system
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
SHMT antisense plants display lower photosynthetic capacity and accumulate glycine in light, glycine is converted to serine in the second half of the light period, serine shows an inverse diurnal rhythm and reaches highest values in darkness, glycine/serine conversion is independent of light in the transformant, but not in the wild-type
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
-
-
r
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
regulatory protein
-
?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
-
key enzyme of serine pathway for assimilation of C1-compounds
-
?
L-serine + tetrahydropteroylglutamate
glycine + 5,10-methylene-tetrahydropteroylglutamate + H2O
-
-
-
-
r
L-serine + tetrahydropteroylglutamate
glycine + 5,10-methylene-tetrahydropteroylglutamate + H2O
-
-
-
-
r
tetrahydrofolate + L-Ser
5,10-methylenetetrahydrofolate + glycine
-
-
-
r
tetrahydrofolate + L-Ser
5,10-methylenetetrahydrofolate + glycine
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
Aedes aegypti NIH Rockefeller
-
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
?
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
?
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
?
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
?
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
?
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
?
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
-
-
-
r
additional information
?
-
-
the enzyme is also active with DL-threo-3-phenylserine
-
-
?
additional information
?
-
purified recombinant ApSHMT protein exhibits catalytic reactions for DL-threo-3-phenylserine as well as for L-serine
-
-
?
additional information
?
-
-
purified recombinant ApSHMT protein exhibits catalytic reactions for DL-threo-3-phenylserine as well as for L-serine
-
-
?
additional information
?
-
-
SHMT1 functions in the photorespiratory pathway and plays a critical role in controlling the cell damage provoked by abiotic stresses such as high light and salt and in restricting pathogen induced cell death
-
-
?
additional information
?
-
-
SHMT1 functions in the photorespiratory pathway and plays a critical role in controlling the cell damage provoked by abiotic stresses such as high light and salt and in restricting pathogen induced cell death
-
-
?
additional information
?
-
-
SHMT also catalyzes the hydrolysis of 5,10-methenyl-tetrahydropteroylglutamate to 5-formyl-tetrahydropteroylglutamate
-
-
?
additional information
?
-
-
broad substrate and reaction specificity
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
-
review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
disruption of the SHM2 gene, encoding one of two serine hydroxymethyltransferase isoenzymes, reduces the flux from glycine to serine
-
-
?
additional information
?
-
-
disruption of the SHM2 gene, encoding one of two serine hydroxymethyltransferase isoenzymes, reduces the flux from glycine to serine
-
-
?
additional information
?
-
enzyme catalyzes the pyridoxal 5'-phosphate dependent reversible cleavage of 3-hydroxy-alpha-amino acids
-
-
?
additional information
?
-
-
enzyme catalyzes the pyridoxal 5'-phosphate dependent reversible cleavage of 3-hydroxy-alpha-amino acids
-
-
?
additional information
?
-
-
review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
enzyme catalyses the racemization of D- and L-alanine
-
-
?
additional information
?
-
-
enzyme catalyses the racemization of D- and L-alanine
-
-
?
additional information
?
-
-
SHMT also catalyzes the hydrolysis of 5,10-methenyl-tetrahydropteroylglutamate to 5-formyl-tetrahydropteroylglutamate
-
-
?
additional information
?
-
-
broad substrate and reaction specificity, overview
-
-
?
additional information
?
-
-
SHMT activity with beta-phenylserine as substrate is about 1.48fold and 1.25fold higher than that with beta-(methylsulfonylphenyl) serine and beta-(nitrophenyl) serine as substrate, respectively. Besides SHMT activity, the enzyme also shows L-allo-threonine aldolase activity, EC 4.1.2.48
-
-
?
additional information
?
-
-
SHMT activity with beta-phenylserine as substrate is about 1.48fold and 1.25fold higher than that with beta-(methylsulfonylphenyl) serine and beta-(nitrophenyl) serine as substrate, respectively. Besides SHMT activity, the enzyme also shows L-allo-threonine aldolase activity, EC 4.1.2.48
-
-
?
additional information
?
-
-
enzyme catalyses the racemization of D- and L-alanine
-
-
?
additional information
?
-
-
enzyme catalyses the racemization of D- and L-alanine
-
-
?
additional information
?
-
SHMT also catalyses several tetrahydrofolate-independent side reactions such as cleavage of beta-hydroxy amino acids, transamination, racemization and decarboxylation
-
-
?
additional information
?
-
-
SHMT also catalyses several tetrahydrofolate-independent side reactions such as cleavage of beta-hydroxy amino acids, transamination, racemization and decarboxylation
-
-
?
additional information
?
-
-
the enzyme also exhibits tetrahydrofolate-independent aldolase activity, EC 4.1.2.5, toward beta-hydroxyamino acids, producing glycine and aldehydes
-
-
?
additional information
?
-
-
review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources
-
-
?
additional information
?
-
-
low activity in placenta suggests that placental conversion of serine to glycine is not a major source of fetal glycine
-
-
?
additional information
?
-
-
the enzyme plays an indispensable role in nucleic acid biosynthesis
-
-
?
additional information
?
-
-
human serine hydroxymethyltransferase 2 binds specifically to heterogeneous nuclear ribonucleoprotein D
-
-
?
additional information
?
-
-
the enzyme also exhibits tetrahydrofolate-independent aldolase activity, EC 4.1.2.5, toward beta-hydroxyamino acids, producing glycine and aldehydes
-
-
?
additional information
?
-
Hydrogenobacter thermophilus TK-6 / IAM 12695
-
the enzyme also exhibits tetrahydrofolate-independent aldolase activity, EC 4.1.2.5, toward beta-hydroxyamino acids, producing glycine and aldehydes
-
-
?
additional information
?
-
-
insoluble enzyme/antibody-complex shows 90% of original activity
-
-
?
additional information
?
-
the enzyme also catalyzes the tetrahydrofolate-independent retroaldol cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde
-
-
?
additional information
?
-
the enzyme also catalyzes the tetrahydrofolate-independent retroaldol cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde
-
-
?
additional information
?
-
SHM1 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
-
-
?
additional information
?
-
SHM1 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
-
-
?
additional information
?
-
-
SHM1 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
-
-
?
additional information
?
-
SHM2 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
-
-
?
additional information
?
-
SHM2 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
-
-
?
additional information
?
-
-
SHM2 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
-
-
?
additional information
?
-
SHM2 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
-
-
?
additional information
?
-
SHM2 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
-
-
?
additional information
?
-
SHM1 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
-
-
?
additional information
?
-
SHM1 does not undergo half-transamination reaction with D-Ala resulting in the formation of the apoenzyme
-
-
?
additional information
?
-
-
review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
-
review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
-
the enzyme also exhibits tetrahydrofolate-independent aldolase activity, EC 4.1.2.5, toward beta-hydroxyamino acids, producing glycine and aldehydes
-
-
?
additional information
?
-
-
enzyme catalyzes the pyridoxal 5'-phosphate dependent reversible cleavage of 3-hydroxy-alpha-amino acids
-
-
?
additional information
?
-
-
enzyme catalyzes the pyridoxal 5'-phosphate dependent reversible cleavage of 3-hydroxy-alpha-amino acids
-
-
?
additional information
?
-
-
enzyme catalyzes the pyridoxal 5'-phosphate dependent reversible cleavage of 3-hydroxy-alpha-amino acids
-
-
?
additional information
?
-
-
mutant enzyme H230Y catalyses oxidation of NADH, not wild type enzyme, H230A, H230F, H230N
-
-
?
additional information
?
-
-
review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
-
enzyme catalyses the racemization of D- and L-alanine
-
-
?
additional information
?
-
-
the enzyme also exhibits THF-independent aldolase activity, EC 4.1.2.5, toward beta-hydroxyamino acids, producing glycine and aldehydes
-
-
?
additional information
?
-
-
review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources
-
-
?
additional information
?
-
-
Plasmodium SHMT can use D-serine and L-serine as a substrate
-
-
?
additional information
?
-
-
SHMT also catalyzes the tetrahydrofolate-independent retro-aldol cleavage of 3-hydroxy amino acids
-
-
?
additional information
?
-
-
Plasmodium SHMT can use D-serine and L-serine as a substrate
-
-
?
additional information
?
-
-
serine hydroxymethyltransferase is a pyridoxal 5'-phosphate-dependent enzyme that catalyzes a hydroxymethyl group transfer from L-serine to tetrahydrofolate to yield glycine and 5,10-methylenetetrahydrofolate
-
-
?
additional information
?
-
the enzyme catalyzes the conversion of L- and D-serine to glycine in a THFdependent reaction
-
-
?
additional information
?
-
-
the enzyme catalyzes the conversion of L- and D-serine to glycine in a THFdependent reaction
-
-
?
additional information
?
-
L- and D-serine substrate binding structure analysis, overview
-
-
?
additional information
?
-
-
L- and D-serine substrate binding structure analysis, overview
-
-
?
additional information
?
-
SHMT catalyses the reversible cleavage of several beta-hydroxy amino acids varying in substituent and stereochemistry at Cbeta. The enzyme also has L-threo-beta-phenylserine aldolase activity
-
-
?
additional information
?
-
SHMT catalyses the reversible cleavage of several beta-hydroxy amino acids varying in substituent and stereochemistry at Cbeta. The enzyme also has L-threo-beta-phenylserine aldolase activity
-
-
?
additional information
?
-
-
enzyme catalyzes the pyridoxal 5'-phosphate dependent reversible cleavage of 3-hydroxy-alpha-amino acids
-
-
?
additional information
?
-
-
review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
-
low activity in placenta suggests that placental conversion of serine to glycine is not a major source of fetal glycine
-
-
?
additional information
?
-
-
enzyme catalyzes the pyridoxal 5'-phosphate dependent reversible cleavage of 3-hydroxy-alpha-amino acids
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
-
no: L-threonine
-
-
?
additional information
?
-
-
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
-
-
?
additional information
?
-
the enzyme shows high serine hydroxymethyltransferase activity and L-serine production
-
-
?
additional information
?
-
-
the enzyme shows high serine hydroxymethyltransferase activity and L-serine production
-
-
?
additional information
?
-
-
review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources
-
-
?
