2.1.2.11: 3-methyl-2-oxobutanoate hydroxymethyltransferase
This is an abbreviated version!
For detailed information about 3-methyl-2-oxobutanoate hydroxymethyltransferase, go to the full flat file.
Word Map on EC 2.1.2.11
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2.1.2.11
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pantothen
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auxotrophs
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aldol
-
l-valine
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beta-alanine
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pane
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betaalpha8
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2-oxoacids
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pharmacology
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alpha-ketobutyrate
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decameric
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4'-phosphopantetheine
- 2.1.2.11
-
pantothen
-
auxotrophs
-
aldol
- l-valine
- beta-alanine
-
pane
-
betaalpha8
- 2-oxoacids
- pharmacology
- alpha-ketobutyrate
-
decameric
- 4'-phosphopantetheine
Reaction
Synonyms
5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase, alpha-ketoisovalerate hydroxymethyltransferase, dehydropantoate hydroxymethyltransferase, hydroxymethyltransferase, ketopantoate, ketopantoate hydroxymethyl transferase, ketopantoate hydroxymethyltransferase, KHMT, KPHMT, MOHMT, oxopantoate hydroxymethyltransferase, PanB
ECTree
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Reference
Reference on EC 2.1.2.11 - 3-methyl-2-oxobutanoate hydroxymethyltransferase
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Teller, J.H.; Powers, S.G.; Snell, E.E.
Ketopantoate hydroxymethyltransferase. I. Purification and role in pantothenate biosynthesis
J. Biol. Chem.
251
3780-3785
1976
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Powers, S.G.; Snell, E.E.
Ketopantoate hydroxymethyltransferase. II. Physical, catalytic, and regulatory properties
J. Biol. Chem.
251
3786-3793
1976
Escherichia coli
Powers, S.G.; Snell, E.E.
Purification and properties of ketopantoate hydroxymethyltransferase
Methods Enzymol.
62
204-209
1979
Escherichia coli
Wightman, R.H.
Stereochemistry of 2-oxopantoate formation by oxopantoate hydroxymethyltransferase
J. Chem. Soc. Chem. Commun.
1979
818-819
1979
Escherichia coli
-
Aberhart, D.J.
Stereochemistry of pantoate biosynthesis from 2-ketoisovalerate
J. Am. Chem. Soc.
101
1354-1355
1979
Escherichia coli
-
Aberhart, D.J.; Russell, D.J.
Steric course of ketopantoate hydroxymethyltransferase in E. coli
J. Am. Chem. Soc.
106
4902-4906
1984
Escherichia coli
-
Baigori, M.; Grau, R.; Morbidoni, H.R.; de Mendoza, D.
Isolation and characterization of Bacillus subtilis mutants blocked in the synthesis of pantothenic acid
J. Bacteriol.
173
4240-4242
1991
Bacillus subtilis
Kim, J.K.; Kim, K.D.; Lim, J.S.; Lee, H.G.; Kim, S.J.; Cho, S.H.; Jeong, W.H.; Choe, I.S.; Chung, T.W.; Paik, S.G.; Choe, Y.K.
Cloning and characterization of the Mycobacterium bovis BCG panB gene encoding ketopantoate hydroxymethyltransferase
J. Biochem. Mol. Biol.
34
342-346
2001
Mycobacterium tuberculosis, Mycobacterium tuberculosis variant bovis, Mycobacterium tuberculosis KIT 10468
-
Jones, C.E.; Brook, J.M.; Buck, D.; Abell, C.; Smith, A.G.
Cloning and sequencing of the Escherichia coli panB gene, which encodes ketopantoate hydroxymethyltransferase, and overexpression of the enzyme
J. Bacteriol.
175
2125-2130
1993
Escherichia coli
Kurtov, D.; Kinghorn, J.R.; Unkles, S.E.
The Aspergillus nidulans panB gene encodes ketopantoate hydroxymethyltransferase, required for biosynthesis of pantothenate and coenzyme A
Mol. Gen. Genet.
262
115-120
1999
Aspergillus nidulans (Q9Y7B6), Aspergillus nidulans
Rubio, A.; Downs, D.M.
Elevated levels of ketopantoate hydroxymethyltransferase (PanB) lead to a physiologically significant coenzyme A elevation in Salmonella enterica serovar typhimurium
J. Bacteriol.
184
2827-2832
2002
Salmonella enterica
Sugantino, M.; Zheng, R.; Yu, M.; Blanchard, J.S.
Mycobacterium tuberculosis ketopantoate hydroxymethyltransferase: Tetrahydrofolate-independent hydroxymethyltransferase and enolization reactions with alpha-keto acids
Biochemistry
42
191-199
2003
Mycobacterium tuberculosis
Schmitzberger, F.; Smith, A.G.; Abell, C.; Blundell, T.L.
Comparative analysis of the Escherichia coli ketopantoate hydroxymethyltransferase crystal structure confirms that it is a member of the (betaalpha)8 phosphoenolpyruvate/pyruvate superfamily
J. Bacteriol.
185
4163-4171
2003
Escherichia coli (P31057), Escherichia coli
von Delft, F.; Inoue, T.; Saldanha, S.A.; Ottenhof, H.H.; Schmitzberger, F.; Birch, L.M.; Dhanaraj, V.; Witty, M.; Smith, A.G.; Blundell, T.L.; Abell, C.
Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites
Structure
11
985-996
2003
Escherichia coli
Pearce, M.J.; Arora, P.; Festa, R.A.; Butler-Wu, S.M.; Gokhale, R.S.; Darwin, K.H.
Identification of substrates of the Mycobacterium tuberculosis proteasome
EMBO J.
25
5423-5432
2006
Mycobacterium tuberculosis
Villasenor, T.; Brom, S.; Davalos, A.; Lozano, L.; Romero, D.; Los Santos, A.G.
Housekeeping genes essential for pantothenate biosynthesis are plasmid-encoded in Rhizobium etli and Rhizobium leguminosarum
BMC Microbiol.
11
66
2011
Rhizobium etli, Rhizobium etli CFN 42
Zhang, B.; Zhang, X.M.; Wang, W.; Liu, Z.Q.; Zheng, Y.G.
Metabolic engineering of Escherichia coli for D-pantothenic acid production
Food Chem.
294
267-275
2019
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032
Thiaville, J.J.; Frelin, O.; Garcia-Salinas, C.; Harrison, K.; Hasnain, G.; Horenstein, N.A.; Diaz de la Garza, R.I.; Henry, C.S.; Hanson, A.D.; de Crecy-Lagard, V.
Experimental and metabolic modeling evidence for a folate-cleaving side-activity of ketopantoate hydroxymethyltransferase (PanB)
Front. Microbiol.
7
431
2016
Escherichia coli, Escherichia coli W3110
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