2.1.2.3: phosphoribosylaminoimidazolecarboxamide formyltransferase

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For detailed information about phosphoribosylaminoimidazolecarboxamide formyltransferase, go to the full flat file.

Reaction

Synonyms

10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase, 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase, 5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase, 5-amino-4-imidazolecarboxamide ribonucleotide transformylase, 5-amino-4-imidazolecarboxamide ribotide formyltransferase, 5-amino-4-imidazolecarboxamide ribotide transformylase, 5-aminoimidazole-4-carboxamide ribonucleotide, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide tranformylase, 5-aminoimidazole-4-carboxamide ribonucleotide tranformylase/IMP cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase (AICAR Tfase)-inosine monophosphate cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide-transformylase, 5-aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase, 5-aminoimidazole-4-carboxamideribonucleotide formyltransferase, AICA ribonucleotide formyltransferase, AICA-ribotide formyltransferase, AICAR formyltransferase, AICAR TFase, AICAR tranformylase, AICAR tranformylase/IMP cyclohydrolase, AICAR transformylase, AICAR transformylase/IMP cyclohydrolase, AICAR transformylase/inosine monophosphate cyclohydrolase, AICAR-transformylase, AICAR-transformylase/IMP cyclohydrolase, AICARFT, AICARFT/IMPCHase, AICARFTase, AICARTfase, AIRCARFTase, aminoimidazole-4-carboxamide ribonucleotide formyltransferase, aminoimidazole-4-carboxamide ribonucleotide transformylase, aminoimidazolecarboxamide ribonucleotide transformylase, aminoimidazolecarboxamide ribotide transformylase, ATIC, atic-1, Bifunctional purine biosynthesis protein, C55F2.1, IMPCH, PurH, TM1249, ZMP formyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.2 Hydroxymethyl-, formyl- and related transferases

                2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase

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Results	in table
1	Activating Compound
38517	AA Sequence
25	Application
1	CAS Registry Number
23	Cloned(Commentary)
26	Cofactor
14	Crystallization (Commentary)
117	Disease/ Diagnostics
2	Expression
29	General Information
1	General Stability
52	IC50 Value
186	Inhibitors
3	kcat/KM [mM/s]
24	Ki Value [mM]
46	KM Value [mM]
8	Localization
4	Metals/Ions
9	Molecular Weight [Da]
84	Natural Substrates/ Products (Substrates)
277	Organism
8	Pathway
46	PDB ID
4	pH Optimum
4	pH Range
4	pH Stability
1	pI Value
1	Posttranslational Modification
9	Protein Variants
28	Purification (Commentary)
2	Reaction
3	Reaction Type
83	Reference
73	Source Tissue
7	Specific Activity [micromol/min/mg]
1	Storage Stability
216	Substrates and Products (Substrate)
21	Subunits
120	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
3	Temperature Range [°C]
5	Temperature Stability [°C]
6	Turnover Number [1/s]

Crystallization

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Crystallization on EC 2.1.2.3 - phosphoribosylaminoimidazolecarboxamide formyltransferase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

purified recombinant His6-tagged PurH, without methylation of the 28 lysine residues, sitting drop vapour diffusion method, mixing of 0.001 ml of 56 mg/ml protein in 0.8 M sodium/potassium hydrogen phosphate, pH 7.5, with 0.001 ml of reservoir solution containing 0.1 M sodium acetate, pH 5.0, 1 M ammonium sulfate, 1 week to 1 month, X-ray diffraction structure determination and analysis at 3.05 A resolution

Escherichia coli

-

718506

crystallized in complex with its inhibitor 2-[5-hydroxy-3-methyl-1-(2-methyl-4-sulfophenyl)-1H-pyrazo]-4-sulfobenzoic acid

Gallus gallus

P31335

659419

recombinant His-tag fusion protein crystallized by sitting drop vapor diffusion method in complex with its inhibitor beta-DADF

Gallus gallus

P31335

657946

ATIC complex crystallized in monoclinic space group P2(1), a = 56.48 A, b = 107.88 A, c = 103.86 A and beta = 91.2°

Gallus sp.

-

485746, 485755, 485759, 485760

crystallized in a binary complex with methotrexate, single crystal at 96 K to 2.3 A resolution, monoclinic crystals, space group P2(1), with unit-cell dimensions a = 65.17, B = 105.93, c= 103.47 A, beta = 108.27 degrees

Gallus sp.

-

485755

-

Homo sapiens

-

485757, 485758

crystal structure analysis of human enzyme complexed with the sulfamido-bridged N-[(S)-(4-([(2-amino-4-hydroxy-quinazolin-6-yl)dihydroxy-lambda-4-sulfanyl]amino)phenyl)-hydroxymethyl]-L-glutamic acid at 2.55 A resolution, PDB ID 1P4R

Homo sapiens

P31939

736619

sitting drop vapor diffusion method, co-crystallized in the presence of substrate with BW1540 and BW2315

Homo sapiens

P31939

652530

purified recombinant His-tagged enzyme free or in complex with substrate 5-aminoimidazole-4-carboxamide ribonucleotide, both with adventitiously active site-bound nucleotide inhibitor of the cyclohydrolase activity, X-ray diffraction structure determination and analysis at 2.5 A and 2.2 A resolution, respectively

Mycobacterium tuberculosis

-

719985

the three-dimensional structure of TM1249 is determined to 1.88 A resolution by molecular replacement

Thermotoga maritima

-

689976