Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.1.2.3: phosphoribosylaminoimidazolecarboxamide formyltransferase

This is an abbreviated version!
For detailed information about phosphoribosylaminoimidazolecarboxamide formyltransferase, go to the full flat file.

Word Map on EC 2.1.2.3

Reaction

10-formyltetrahydrofolate
+
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
=
tetrahydrofolate
 +
5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

Synonyms

10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase, 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase, 5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase, 5-amino-4-imidazolecarboxamide ribonucleotide transformylase, 5-amino-4-imidazolecarboxamide ribotide formyltransferase, 5-amino-4-imidazolecarboxamide ribotide transformylase, 5-aminoimidazole-4-carboxamide ribonucleotide, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide tranformylase, 5-aminoimidazole-4-carboxamide ribonucleotide tranformylase/IMP cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase (AICAR Tfase)-inosine monophosphate cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide-transformylase, 5-aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase, 5-aminoimidazole-4-carboxamideribonucleotide formyltransferase, AICA ribonucleotide formyltransferase, AICA-ribotide formyltransferase, AICAR formyltransferase, AICAR TFase, AICAR tranformylase, AICAR tranformylase/IMP cyclohydrolase, AICAR transformylase, AICAR transformylase/IMP cyclohydrolase, AICAR transformylase/inosine monophosphate cyclohydrolase, AICAR-transformylase, AICAR-transformylase/IMP cyclohydrolase, AICARFT, AICARFT/IMPCHase, AICARFTase, AICARTfase, AIRCARFTase, aminoimidazole-4-carboxamide ribonucleotide formyltransferase, aminoimidazole-4-carboxamide ribonucleotide transformylase, aminoimidazolecarboxamide ribonucleotide transformylase, aminoimidazolecarboxamide ribotide transformylase, ATIC, atic-1, Bifunctional purine biosynthesis protein, C55F2.1, IMPCH, PurH, TM1249, ZMP formyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.2 Hydroxymethyl-, formyl- and related transferases
                2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase

IC50 Value

IC50 Value on EC 2.1.2.3 - phosphoribosylaminoimidazolecarboxamide formyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.012
2-[5-hydroxy-3-methyl-1-(2-methyl-4-sulfophenyl)-1H-pyrazo]-4-sulfobenzoic acid
Gallus gallus
Acid Yellow 54, 326203-A, competitive against 10-formyltetrahydrofolate, IC50: 0.012 mM, inhibitor partially blocks the cofactor binding site
0.09
3-[(4-cyanobenzene-1-sulfonyl)amino]benzamide
Homo sapiens
at pH 7.5 and 25°C
0.0348
4-chloro-N-(1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)benzene-1-sulfonamide
Homo sapiens
at pH 7.5 and 25°C
0.000608
4-cyano-N-(1-oxo-1,2-dihydroisoquinolin-7-yl)benzene-1-sulfonamide
Homo sapiens
at pH 7.5 and 25°C
0.000723
4-cyano-N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)benzene-1-sulfonamide
Homo sapiens
at pH 7.5 and 25°C
0.1
4-cyano-N-phenylbenzene-1-sulfonamide
Homo sapiens
IC50 above 0.1 mM, at pH 7.5 and 25°C
0.000005
5-(5,5-dimethyl-6-oxo-1,4-dihydropyridin-3-yl)-N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)thiophene-2-sulfonamide
Homo sapiens
IC50 below 0.000005 mM, at pH 7.5 and 25°C
0.000005
5-(5-ethyl-5-methyl-6-oxo-1,4-dihydropyridin-3-yl)-N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)thiophene-2-sulfonamide
Homo sapiens
IC50 below 0.000005 mM, at pH 7.5 and 25°C
0.00002
5-[(3R,4S)-3-fluoro-4-hydroxypyrrolidin-1-yl]-N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)thiophene-2-sulfonamide
Homo sapiens
at pH 7.5 and 25°C
0.0000078
5-[(3S,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl]-N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)thiophene-2-sulfonamide
Homo sapiens
at pH 7.5 and 25°C
0.000012
5-[(4R)-3,3-difluoro-4-hydroxypyrrolidin-1-yl]-N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)thiophene-2-sulfonamide
Homo sapiens
at pH 7.5 and 25°C
0.000013
5-[(4S)-3,3-difluoro-4-hydroxypyrrolidin-1-yl]-N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)thiophene-2-sulfonamide
Homo sapiens
at pH 7.5 and 25°C
0.012
Acid Yellow 17
Gallus gallus
IC50: 0.012 mM
0.000125
beta-DADF
Gallus gallus
IC50 125 nM
0.0181
N-(2-amino-4-oxo-3,4-dihydroquinazolin-6-yl)-4-cyanobenzene-1-sulfonamide
Homo sapiens
at pH 7.5 and 25°C
0.000013
N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-(4-hydroxypiperidin-1-yl)thiophene-2-sulfonamide
Homo sapiens
at pH 7.5 and 25°C
0.000014 - 0.000016
N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide
0.000005
N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)-5-(6-oxo-1H-pyridin-3-yl)thiophene-2-sulfonamide
Homo sapiens
IC50 below 0.000005 mM, at pH 7.5 and 25°C
0.000026
N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)-5-[(3R)-3-hydroxy-1-piperidyl]thiophene-2-sulfonamide
Homo sapiens
at pH 7.5 and 25°C
0.000018
N-(6-fluoro-1-oxo-2H-isoquinolin-7-yl)-5-[(3S)-3-hydroxy-1-piperidyl]thiophene-2-sulfonamide
Homo sapiens
at pH 7.5 and 25°C
0.042
NCI324571-C
Gallus gallus
IC50: 0.042 mM
0.012
NCI324572-F
Gallus gallus
IC50: 0.012 mM
0.012
NCI3262203-A
Gallus gallus
IC50: 0.012 mM
0.003
NCI47729-M
Gallus gallus
IC50: 0.003 mM
0.01
NSC126445
Homo sapiens
IC50: 0.010mM
0.036
NSC170645
Homo sapiens
IC50: 0.036 mM
0.017
NSC26699
Homo sapiens
IC50: 0.017 mM
0.009
NSC292213
Homo sapiens
IC50: 0.009 mM
0.0006
NSC30171
Homo sapiens
IC50: 0.0006 mM
0.106
NSC321237
Homo sapiens
IC50: 0.106 mM
0.02
NSC324571
Homo sapiens
IC50: 0.020 mM
0.012
NSC324572
Homo sapiens
IC50: 0.012 mM
0.02
NSC324981
Homo sapiens
IC50: 0.020 mM
0.012
NSC326203
Homo sapiens
IC50: 0.012 mM
0.204
NSC326211
Homo sapiens
IC50: 0.204 mM
0.008
NSC37031
Homo sapiens
IC50: 0.008 mM
0.004
NSC37173
Homo sapiens
IC50: 0.004 mM
0.055
NSC41806
Homo sapiens
IC50: 0.055 mM
0.012
NSC45592
Homo sapiens
IC50: 0.012 mM
0.003
NSC47729
Homo sapiens
IC50: 0.003 mM
0.008
NSC58046
Homo sapiens
IC50: 0.008 mM
0.231
NSC7524
Homo sapiens
IC50: 0.231 mM
0.014
NSC88915
Homo sapiens
IC50: 0.014 mM
0.0014
SALOR2
Gallus gallus
IC50: 0.0014 mM
additional information
N-(4-[[(2,4-diaminopteridin-6-yl)methyl](methyl)amino]benzoyl)glutamic acid