2.1.2.3: phosphoribosylaminoimidazolecarboxamide formyltransferase

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For detailed information about phosphoribosylaminoimidazolecarboxamide formyltransferase, go to the full flat file.

Reaction

Synonyms

10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase, 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase, 5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase, 5-amino-4-imidazolecarboxamide ribonucleotide transformylase, 5-amino-4-imidazolecarboxamide ribotide formyltransferase, 5-amino-4-imidazolecarboxamide ribotide transformylase, 5-aminoimidazole-4-carboxamide ribonucleotide, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide tranformylase, 5-aminoimidazole-4-carboxamide ribonucleotide tranformylase/IMP cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase (AICAR Tfase)-inosine monophosphate cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide-transformylase, 5-aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase, 5-aminoimidazole-4-carboxamideribonucleotide formyltransferase, AICA ribonucleotide formyltransferase, AICA-ribotide formyltransferase, AICAR formyltransferase, AICAR TFase, AICAR tranformylase, AICAR tranformylase/IMP cyclohydrolase, AICAR transformylase, AICAR transformylase/IMP cyclohydrolase, AICAR transformylase/inosine monophosphate cyclohydrolase, AICAR-transformylase, AICAR-transformylase/IMP cyclohydrolase, AICARFT, AICARFT/IMPCHase, AICARFTase, AICARTfase, AIRCARFTase, aminoimidazole-4-carboxamide ribonucleotide formyltransferase, aminoimidazole-4-carboxamide ribonucleotide transformylase, aminoimidazolecarboxamide ribonucleotide transformylase, aminoimidazolecarboxamide ribotide transformylase, ATIC, atic-1, Bifunctional purine biosynthesis protein, C55F2.1, IMPCH, PurH, TM1249, ZMP formyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.2 Hydroxymethyl-, formyl- and related transferases

                2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase

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Results	in table
1	Activating Compound
38517	AA Sequence
25	Application
1	CAS Registry Number
23	Cloned(Commentary)
26	Cofactor
14	Crystallization (Commentary)
117	Disease/ Diagnostics
2	Expression
29	General Information
1	General Stability
52	IC50 Value
186	Inhibitors
3	kcat/KM [mM/s]
24	Ki Value [mM]
46	KM Value [mM]
8	Localization
4	Metals/Ions
9	Molecular Weight [Da]
84	Natural Substrates/ Products (Substrates)
277	Organism
8	Pathway
46	PDB ID
4	pH Optimum
4	pH Range
4	pH Stability
1	pI Value
1	Posttranslational Modification
9	Protein Variants
28	Purification (Commentary)
2	Reaction
3	Reaction Type
83	Reference
73	Source Tissue
7	Specific Activity [micromol/min/mg]
1	Storage Stability
216	Substrates and Products (Substrate)
21	Subunits
120	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
3	Temperature Range [°C]
5	Temperature Stability [°C]
6	Turnover Number [1/s]

KI Value

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KI Value on EC 2.1.2.3 - phosphoribosylaminoimidazolecarboxamide formyltransferase

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00137

10-formylfolic acid pentaglutamate

Gallus sp.

-

-

485749

0.007

2-[5-hydroxy-3-methyl-1-(2-methyl-4-sulfophenyl)-1H-pyrazo]-4-sulfobenzoic acid

Gallus gallus

P31335

pH 7.5

659419

0.006

5-amino-1-beta-D-ribofuranosylimidazole 5'-phosphate

Homo sapiens

-

-

485756

0.026

5-amino-1-beta-D-ribofuranosylimidazole-4-carbonitrile 5'-phosphate

Homo sapiens

-

-

485756

0.01

5-amino-1-beta-D-ribofuranosylimidazole-4-carboxylate 5'-phosphate

Homo sapiens

-

-

485756

0.0007

5-amino-4-nitro-1-beta-D-ribofuranosylimidazole 5'-phosphate

Homo sapiens

-

-

485756

0.00004 - 0.0007

5-amino-4-nitroimidazole ribonucleotide

2 entries

0.00007 - 0.0004

5-formyl-5-aminoimidazole-4-carboxamide ribonucleotide

2 entries

0.027

AMP

Homo sapiens

-

-

485756

0.09 - 0.12

Azathioprine

2 entries

0.000008

BW1540

Homo sapiens

P31939

-

652530

0.000006

BW2315

Homo sapiens

P31939

-

652530

0.003

Cappsin 1

Homo sapiens

-

-

658284

0.00014

dihydrofolic acid pentaglutamate

Gallus sp.

-

-

485749

0.00008

folic acid pentaglutamate

Gallus sp.

-

-

485749

0.075

methotrexate

Gallus sp.

-

-

485749

0.00315

methotrexate polyglutamate

Gallus sp.

-

-

485749

0.000015

NSC30171

Homo sapiens

P31939

-

659681

0.039 - 0.11

thioinosinic acid

2 entries

0.0012

XMP

Homo sapiens

-

-

485756

0.00004

5-amino-4-nitroimidazole ribonucleotide

Mus musculus

-

-

485749

0.0007

5-amino-4-nitroimidazole ribonucleotide

Homo sapiens

-

-

485756

0.00007

5-formyl-5-aminoimidazole-4-carboxamide ribonucleotide

Mus musculus

-

-

485749

0.0004

5-formyl-5-aminoimidazole-4-carboxamide ribonucleotide

Homo sapiens

-

-

485756

0.09

Azathioprine

Mus musculus

-

-

485750

0.12

Azathioprine

Gallus sp.

-

-

485750

0.039

thioinosinic acid

Gallus sp.

-

-

485750

0.11

thioinosinic acid

Mus musculus

-

-

485750