2.1.2.7: D-alanine 2-hydroxymethyltransferase

This is an abbreviated version!
For detailed information about D-alanine 2-hydroxymethyltransferase, go to the full flat file.

Reaction

Synonyms

2-methylserine hydroxymethyltransferase, alpha-methylserine hydroxymethyltransferase, hydroxymethyltransferase, 2-methylserine, MSHMT

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.2 Hydroxymethyl-, formyl- and related transferases

                2.1.2.7 D-alanine 2-hydroxymethyltransferase

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Results	in table
3	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
5	Cofactor
2	Crystallization (Commentary)
4	General Stability
18	Inhibitors
6	Ki Value [mM]
12	KM Value [mM]
3	Localization
2	Molecular Weight [Da]
9	Organism
2	Pathway
4	pH Optimum
1	pH Range
2	pH Stability
4	Purification (Commentary)
1	Reaction
1	Reaction Type
8	Reference
6	Specific Activity [micromol/min/mg]
22	Substrates and Products (Substrate)
2	Subunits
7	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 2.1.2.7 - D-alanine 2-hydroxymethyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2-methyl-L-serine + tetrahydrofolate

D-alanine + 5,10-methylenetetrahydrofolate

2 entries

tetrahydrofolate + (+)-2-methylserine

5,10-methylenetetrahydrofolate + D-alanine + H2O

6 entries

tetrahydrofolate + (-)-ethylserine

5,10-methylenetetrahydrofolate + D-2-aminobutyrate + H2O

4 entries

tetrahydrofolate + 2-ethyl-DL-serine

5,10-methylenetetrahydrofolate + D-2-aminobutyrate + H2O

2 entries

tetrahydrofolate + 2-hydroxymethylserine

5,10-methylenetetrahydrofolate + D-serine + H2O

4 entries

tetrahydrofolate + 2-methyl-DL-serine

5,10-methylenetetrahydrofolate + D-alanine + H2O

2 entries

2-methyl-L-serine + tetrahydrofolate

D-alanine + 5,10-methylenetetrahydrofolate

Aminobacter sp. AJ110403

B2DEU8

assay at pH 7.4, 30°C

702735

-

-

r

2-methyl-L-serine + tetrahydrofolate

D-alanine + 5,10-methylenetetrahydrofolate

Ensifer sp. AJ110404

B2DEV1

assay at pH 7.4, 30°C

702735

-

-

r

tetrahydrofolate + (+)-2-methylserine

5,10-methylenetetrahydrofolate + D-alanine + H2O

Clostridium tetanomorphum

-

-

485779

-

-

?

tetrahydrofolate + (+)-2-methylserine

5,10-methylenetetrahydrofolate + D-alanine + H2O

Escherichia coli

-

-

485779

-

-

?

tetrahydrofolate + (+)-2-methylserine

5,10-methylenetetrahydrofolate + D-alanine + H2O

Pseudomonas sp.

-

stereospecific, dimedon cannot replace tetrahydrofolate

485776

-

485776

r

tetrahydrofolate + (+)-2-methylserine

5,10-methylenetetrahydrofolate + D-alanine + H2O

Pseudomonas sp.

-

stereospecific, dimedon cannot replace tetrahydrofolate

485778

-

485778

r

tetrahydrofolate + (+)-2-methylserine

5,10-methylenetetrahydrofolate + D-alanine + H2O

Pseudomonas sp.

-

stereospecific, dimedon cannot replace tetrahydrofolate

485777

5,10-methylenetetrahydrofolate is non-enzymatically cleaved to tetrahydrofolate and formaldehyde

485777

r

tetrahydrofolate + (+)-2-methylserine

5,10-methylenetetrahydrofolate + D-alanine + H2O

Pseudomonas sp. MS

-

stereospecific, dimedon cannot replace tetrahydrofolate

485777

5,10-methylenetetrahydrofolate is non-enzymatically cleaved to tetrahydrofolate and formaldehyde

485777

r

tetrahydrofolate + (-)-ethylserine

5,10-methylenetetrahydrofolate + D-2-aminobutyrate + H2O

Pseudomonas sp.

-

-

485776

-

485776

r

tetrahydrofolate + (-)-ethylserine

5,10-methylenetetrahydrofolate + D-2-aminobutyrate + H2O

Pseudomonas sp.

-

-

485777

-

485777

r

tetrahydrofolate + (-)-ethylserine

5,10-methylenetetrahydrofolate + D-2-aminobutyrate + H2O

Pseudomonas sp.

-

stereospecific

485778

-

485778

r

tetrahydrofolate + (-)-ethylserine

5,10-methylenetetrahydrofolate + D-2-aminobutyrate + H2O

Pseudomonas sp. MS

-

-

485777

-

485777

r

tetrahydrofolate + 2-ethyl-DL-serine

5,10-methylenetetrahydrofolate + D-2-aminobutyrate + H2O

Pseudomonas sp.

-

-

485776, 485777

-

-

r

tetrahydrofolate + 2-ethyl-DL-serine

5,10-methylenetetrahydrofolate + D-2-aminobutyrate + H2O

Pseudomonas sp. MS

-

-

485777

-

-

r

tetrahydrofolate + 2-hydroxymethylserine

5,10-methylenetetrahydrofolate + D-serine + H2O

Pseudomonas sp.

-

-

485777

-

485777

?

tetrahydrofolate + 2-hydroxymethylserine

5,10-methylenetetrahydrofolate + D-serine + H2O

Pseudomonas sp.

-

specific removal of one of the two hydroxyl groups

485776

-

485776

r

tetrahydrofolate + 2-hydroxymethylserine

5,10-methylenetetrahydrofolate + D-serine + H2O

Pseudomonas sp.

-

specific removal of one of the two hydroxyl groups

485778

-

-

r

tetrahydrofolate + 2-hydroxymethylserine

5,10-methylenetetrahydrofolate + D-serine + H2O

Pseudomonas sp. MS

-

-

485777

-

485777

?

tetrahydrofolate + 2-methyl-DL-serine

5,10-methylenetetrahydrofolate + D-alanine + H2O

Pseudomonas sp.

-

-

485776, 485777

-

-

r

tetrahydrofolate + 2-methyl-DL-serine

5,10-methylenetetrahydrofolate + D-alanine + H2O

Pseudomonas sp. MS

-

-

485777

-

-

r