2.1.2.9: methionyl-tRNA formyltransferase

This is an abbreviated version!
For detailed information about methionyl-tRNA formyltransferase, go to the full flat file.

Reaction

Synonyms

FMT, FMT1, Fmt1p, formyl-methionyl transferase, formylmethionyl-transfer ribonucleic synthetase, methionyl ribonucleic formyltransferase, methionyl-transfer ribonucleic transformylase, methionyl-transfer RNA transformylase, methionyl-tRNA formyltransferase, methionyl-tRNA Met formyltransferase, methionyl-tRNA transformylase, methionyl-tRNA-Formyltransferase, methyltransferase, methionyl-transfer ribonucleate, mitochondrial methionyl-tRNA formyltransferase, MTF, MTFMT, N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.2 Hydroxymethyl-, formyl- and related transferases

                2.1.2.9 methionyl-tRNA formyltransferase

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Results	in table
2	Activating Compound
46946	AA Sequence
1	CAS Registry Number
14	Cloned(Commentary)
29	Cofactor
7	Crystallization (Commentary)
77	Disease/ Diagnostics
18	General Information
3	General Stability
17	Inhibitors
5	Ki Value [mM]
57	KM Value [mM]
27	Localization
27	Metals/Ions
11	Molecular Weight [Da]
44	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
337	Organism
3	Pathway
18	PDB ID
5	pH Optimum
3	pH Range
71	Protein Variants
18	Purification (Commentary)
1	Reaction
1	Reaction Type
58	Reference
5	Source Tissue
12	Specific Activity [micromol/min/mg]
8	Storage Stability
239	Substrates and Products (Substrate)
5	Subunits
33	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
32	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.1.2.9 - methionyl-tRNA formyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

10-formyltetrahydrofolate + L-methionyl-tRNAfMet

tetrahydrofolate + N-formylmethionyl-tRNAfMet

8 entries

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

30 entries

additional information

?

-

5 entries

10-formyltetrahydrofolate + L-methionyl-tRNAfMet

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli

P23882

-

736461

-

-

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Homo sapiens

-

-

719239, 757809

-

-

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Homo sapiens

Q96DP5

-

736461

-

-

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Saccharomyces cerevisiae

-

-

756708

-

-

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Staphylococcus aureus

-

-

735441

-

-

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Staphylococcus aureus WCUH29

-

-

735441

-

-

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Toxoplasma gondii

-

-

720491

-

-

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Toxoplasma gondii RH

-

-

720491

-

-

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Enterococcus faecalis

-

involved in initiation of protein biosynthesis

485802

-

485802

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Enterococcus faecalis R / ATCC 8043

-

involved in initiation of protein biosynthesis

485802

-

485802

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli

-

keeps in store initiator tRNAfMet for initiation of protein synthesis

485798

-

485798

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli

-

involved in initiation of protein biosynthesis

485795

-

485795

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli

-

involved in initiation of protein biosynthesis

485796

-

485796

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli

-

involved in initiation of protein biosynthesis

485797

-

485797

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli

-

involved in initiation of protein biosynthesis

485798

-

485798

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli

-

involved in initiation of protein biosynthesis

485802

-

485802

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli

-

involved in initiation of protein biosynthesis

485809

-

485809

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli

-

involved in initiation of protein biosynthesis

485810

-

485810

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli

-

involved in initiation of protein biosynthesis

485811

-

485811

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli

P23882

involved in initiation of protein biosynthesis

485812

-

485812

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli

P23882

involved in initiation of protein biosynthesis

485815

-

485815

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli

P23882

formyl group provides a positive determinant for IF2, which can select the initiator fMet-tRNA from other tRNAs and a negative determinant, which blocks the binding of EF-Tu to the initiator tRNA

485815

-

485815

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli

P23882

enzyme reaction irreversibly commits methionyl-tRNAfMet to initiation of translation in eubacteria

485805

-

485805

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli

-

key step in the targeting of initiator tRNA towards the translation start machinery in prokaryotes

485806

-

485806

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli

-

small effect of overproduction of MRF on activity of chloramphenicol acetyltransferase

657992

-

-

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli A19

-

involved in initiation of protein biosynthesis

485802

-

485802

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli CA274

-

involved in initiation of protein biosynthesis

485809

-

485809

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli CA274

-

involved in initiation of protein biosynthesis

485810

-

485810

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli DH5-alphaF

-

involved in initiation of protein biosynthesis

485809

-

485809

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli JM109

-

involved in initiation of protein biosynthesis

485809

-

485809

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli JM109

-

involved in initiation of protein biosynthesis

485810

-

485810

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Escherichia coli K12 MO

-

involved in initiation of protein biosynthesis

485796

-

485796

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Euglena gracilis

-

involved in initiation of protein synthesis in chloroplasts, other mechanism than in cytoplasm of eukaryotes

485800

-

485800

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Euglena gracilis Z

-

involved in initiation of protein synthesis in chloroplasts, other mechanism than in cytoplasm of eukaryotes

485800

-

485800

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Saccharomyces cerevisiae

-

initiation of protein synthesis in mitochondria

485813

-

485813

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Saccharomyces cerevisiae

P32785

the dispensable mitochondrial methionyl-tRNAformyltransferase, Fmt1p, is essential for respiratory growth in the absence of Rsm28p

673867

-

-

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Triticum aestivum

-

component of a protein chain initiating system in chloroplasts

485804

-

485804

?

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O

tetrahydrofolate + N-formylmethionyl-tRNAfMet

Trypanosoma brucei

-

formylation of the methionyl-tRNA-fMet is essential for in vitro binding of imported formylated elongator-type tRNA(Met)

659462

-

-

?

additional information

?

-

Bos taurus

-

translational initiation in mitochondria

485807

-

-

?

additional information

?

-

Bos taurus

-

translational initiation in mitochondria

485808

-

-

?

additional information

?

-

Saccharomyces cerevisiae

-

mitochondrial protein synthesis

485803

-

-

?

additional information

?

-

Saccharomyces cerevisiae D243-2B-R1

-

mitochondrial protein synthesis

485803

-

-

?

additional information

?

-

Salmonella enterica

-

resistance mutations are identified in the fmt gene encoding the enzyme methionyl-tRNA formyltransferase. In the absence of antibiotic, these resistance mutations confer a fitness cost that is manifested as a reduced growth rate in laboratory medium and in mice

676864

-

-

?