2.1.3.11: N-succinylornithine carbamoyltransferase

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For detailed information about N-succinylornithine carbamoyltransferase, go to the full flat file.

Reaction

Synonyms

ArgF, N-succinyl-L-ornithine transcarbamylase, SOTC, SOTCase, succinylornithine transcarbamylase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.3 Carboxy- and carbamoyltransferases

                2.1.3.11 N-succinylornithine carbamoyltransferase

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Results	in table
2420	AA Sequence
1	CAS Registry Number
3	Crystallization (Commentary)
4	KM Value [mM]
3	Natural Substrates/ Products (Substrates)
5	Organism
7	Protein Variants
1	Reaction
5	Reference
4	Specific Activity [micromol/min/mg]
8	Substrates and Products (Substrate)
8	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.1.3.11 - N-succinylornithine carbamoyltransferase

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SYSTEMATIC NAME

IUBMB Comments

carbamoyl phosphate:N2-succinyl-L-ornithine carbamoyltransferase

This enzyme is specific for N-succinyl-L-ornithine and cannot use either L-ornithine (see EC 2.1.3.3, ornithine carbamoyltransferase) or N-acetyl-L-ornithine (see EC 2.1.3.9, N-acetylornithine carbamoyltransferase) as substrate. However, a single amino-acid substitution (Pro90 -> Glu90) is sufficient to switch the enzyme to one that uses N-acetyl-L-ornithine as substrate. It is essential for de novo arginine biosynthesis in the obligate anaerobe Bacteroides fragilis, suggesting that this organism uses an alternative pathway for synthesizing arginine.