2.1.3.12: decarbamoylnovobiocin carbamoyltransferase
This is an abbreviated version!
For detailed information about decarbamoylnovobiocin carbamoyltransferase, go to the full flat file.
Reaction
Synonyms
NovN
ECTree
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Substrates Products
Substrates Products on EC 2.1.3.12 - decarbamoylnovobiocin carbamoyltransferase
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REACTION DIAGRAM
2 carbamoyl phosphate + N,N'-bis(7-[[(2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl)-3-methyl-1H-pyrrole-2,4-dicarboxamide
2 phosphate + (3-methyl-1H-pyrrole-2,4-diyl)bis[carbonylimino(4-hydroxy-8-methyl-2-oxo-2H-chromene-3,7-diyl)oxy-(2R,3R,4S,5R)-3-hydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2,4-diyl] dicarbamate
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the tandem action of CouL, CouM, CouP, and NovN generates a biscarbamoyl analogue of the pseudodimer coumermycin A1
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?
carbamoyl phosphate + novclobiocin 104
phosphate + ?
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87% of novclobiocin 104 is converted to the carbamoylated derivative after overnight incubation
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?
carbamoyl phosphate + novclobiocin 105
phosphate + novclobiocin 115
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?
carbamoyl phosphate + novclobiocin 107
phosphate + novclobiocin 117
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?
carbamoyl phosphate + novclobiocin 108
phosphate + novclobiocin 118
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?
carbamoyl phosphate + novclobiocin 283
phosphate + novclobiocin 284
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?
phosphate + novobiocin
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?
carbamoyl phosphate + decarbamoylnovobiocin
phosphate + novobiocin
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the enzyme is involved in the biosynthesis of the aminocoumarin antibiotics, novobiocin
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?
carbamoyl phosphate + decarbamoylnovobiocin
phosphate + novobiocin
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NovN is specific for carbamoyl phosphate as substrate. With acetyl phosphate, no product formation is observed
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?