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2.1.3.3: ornithine carbamoyltransferase

This is an abbreviated version!
For detailed information about ornithine carbamoyltransferase, go to the full flat file.

Word Map on EC 2.1.3.3

Reaction

Carbamoyl phosphate
+
L-ornithine
=
phosphate
 +
L-citrulline

Synonyms

anabolic ornithine carbamoyltransferase, anabolic ornithine transcarbamoylase, AOTC, arcB gene product, ArgF, ArgK, aTtOTCase, carbamoyltransferase, carbamoyltransferase, ornithine, carbamylphosphate-ornithine transcarbamylase, catabolic ornithine carbamoyltransferase, catabolic ornithine transcarbamylase, citrulline phosphorylase, cOTC, L-ornithine carbamoyltransferase, L-ornithine carbamyltransferase, L-ornithine transcarbamylase, Lmo0036, MB1684, Mtb OTC, OCT, ornithine carbamoyltransferase, ornithine carbamoytransferase, ornithine carbamyl transferase, ornithine carbamyltransferase, ornithine transcarbamoylase, ornithine transcarbamylase, ornithine transcarbamylase 3, OTC, otcase, ROTCase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.3 Carboxy- and carbamoyltransferases
                2.1.3.3 ornithine carbamoyltransferase

KI Value

KI Value on EC 2.1.3.3 - ornithine carbamoyltransferase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
7
2,4-diaminobutyrate
-
-
8.2
arginine
-
determined in the presence of 0.5 mM ornithine and 0.5 mM carbamoylphosphate
0.012 - 0.151
Carbamoyl phosphate
0.00001 - 0.000025
delta-N-(phosphonacetyl)-L-ornithine
0.27
delta-N-(phosphonoacetyl)-L-ornithine
-
at 30°C and pH 7.4, competitive vs. carbamoyl phosphate, noncompetitive vs. ornithine
0.0000047 - 0.0115
Delta-N-Phosphonoacetyl-L-ornithine
1.1
diaminobutyric acid
-
pH 8.5, 37°C
15
glycine
-
-
13
L-alanine
-
-
0.58
L-alpha-aminobutyrate
-
-
110
L-asparagine
-
-
40
L-histidin
-
-
10.5 - 14
L-isoleucine
1.2 - 5.5
L-leucine
40
L-methionine
-
-
0.071 - 1.7
L-norvaline
1.9
L-ornithine
-
pH 8.5, 37°C
63.5
L-serine
-
-
12.5 - 13.5
L-valine
0.0002 - 0.0009
N-delta-(phosphosulfamyl)ornithylalanylhomoarginine
0.06 - 3.6
ornithine
0.25 - 8
phosphate
0.01
phosphonacetyl-L-ornithine
-
between pH 7.5-9.0
additional information
additional information
-