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2.1.3.3: ornithine carbamoyltransferase

This is an abbreviated version!
For detailed information about ornithine carbamoyltransferase, go to the full flat file.

Word Map on EC 2.1.3.3

Reaction

Carbamoyl phosphate
+
L-ornithine
=
phosphate
 +
L-citrulline

Synonyms

anabolic ornithine carbamoyltransferase, anabolic ornithine transcarbamoylase, AOTC, arcB gene product, ArgF, ArgK, aTtOTCase, carbamoyltransferase, carbamoyltransferase, ornithine, carbamylphosphate-ornithine transcarbamylase, catabolic ornithine carbamoyltransferase, catabolic ornithine transcarbamylase, citrulline phosphorylase, cOTC, L-ornithine carbamoyltransferase, L-ornithine carbamyltransferase, L-ornithine transcarbamylase, Lmo0036, MB1684, Mtb OTC, OCT, ornithine carbamoyltransferase, ornithine carbamoytransferase, ornithine carbamyl transferase, ornithine carbamyltransferase, ornithine transcarbamoylase, ornithine transcarbamylase, ornithine transcarbamylase 3, OTC, otcase, ROTCase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.3 Carboxy- and carbamoyltransferases
                2.1.3.3 ornithine carbamoyltransferase

Specific Activity

Specific Activity on EC 2.1.3.3 - ornithine carbamoyltransferase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00058
-
crude cell extract
0.0657
-
purified enzyme
0.0928
-
isoenzyme 2 with ornithine
0.255
-
pH 8.0, 55°C, activity in cell culture in minimal growth medium with 20 mM glucose and 5 mM NH4+
0.43
-
pH 8.0, 55°C, activity in cell culture in growth medium with 0.5% peptone and 0.1% yeast extract
0.47
-
multifunctional enzyme
0.574
-
isoenzyme 1 with canaline
1.24
-
isoenzyme 2 with canaline
1.28
-
mutant T68G, pH 8.0, 30°C
12.33
-
mutant N184Q, pH 8.0, 30°C
12.66
-
mutant E256Q, pH 8.0, 30°C
12.67
-
pH 7.5, crude cell exstract
13.3
-
mutant L290Q, pH 8.0, 30°C
14.83
-
mutant K263R, pH 8.0, 30°C
15
-
mutant E256A, pH 8.0, 30°C
157.8
-
-
16.16
-
mutant D182N, pH 8.0, 30°C
16.83
-
mutant K265A, pH 8.0, 30°C
2.33
-
extracts prepared from Escherichia coli CM236 carrying pME178
2.83
-
mutant K289S, pH 8.0, 30°C
23.38
-
mutant E123S, pH 8.0, 30°C
23.63
-
mutant K265R, pH 8.0, 30°C
24
recombinant wild-type enzyme, substrate L-ornithine, pH 8.5, 37°C
25.16
-
mutant K260R, pH 8.0, 30°C
25.3
-
mutant E123A, pH 8.0, 30°C
25.73
-
mutant K268R, pH 8.0, 30°C
25.83
-
mutant K260A, pH 8.0, 30°C
250 - 260
-
-
26.12
-
wild-type, pH 8.0, 30°C
26.4
-
-
3.33
-
recombinant enzyme
3.59
-
anabolic reaction, pH 10.0, 37°C
4.16
-
mutant C191M/C194N/F197V, pH 8.0, 30°C
4.66
-
mutant L290S, pH 8.0, 30°C
40.2
-
recombinant enzyme
450
-
pH 7.5, purified enzyme
48.66
-
mutant Q294P, pH 8.0, 30°C
5.56
-
isoenzyme 1
7.5
-
mutant K263A, pH 8.0, 30°C
780
-
-
8.31
-
isoenzyme 1 with ornithine
82
recombinant enzyme mutant Y230V/G231S/L232M/Y233G, substrate L-ornithine, pH 8.5, 37°C
83.3
-
enzyme from a liver of a Reye's syndrome patient
86.5
-
enzyme from normal liver
additional information