2.1.3.6: putrescine carbamoyltransferase
This is an abbreviated version!
For detailed information about putrescine carbamoyltransferase, go to the full flat file.
Word Map on EC 2.1.3.6
Reaction
Synonyms
anabolic putrescine carbamoyltransferase, aPTC, catabolic putrescine carbamoyltransferase, cPTC, Lmo0036, PTC, PTCase, putrescine carbamoyltransferase, putrescine synthase, putrescine transcarbamylase
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General Information on EC 2.1.3.6 - putrescine carbamoyltransferase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
malfunction
metabolism
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catabolic ornithine and putrescine carbamoyltransfer reactions constitute the second step of arginine deiminase and agmatine deiminase pathways. However, the equilibrium of in vitro carbamoyltransfer reactions is overwhelmingly towards the anabolic direction, suggesting that catabolic carbamoyltransferase is probably the limiting step of the pathways. lmo0036 is induced at the transcriptional level when Listeria monocytogenes is subjected to low-pH stress. Its expression product in Escherichia coli exhibits higher catabolic carbamoyltransfer activities under acidic conditions
physiological function
additional information
malfunction
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absence of this enzyme impairs the growth of Listeria under mild acidic conditions at pH 4.8 and reduced its survival in synthetic human gastric fluid at pH 2.5, corresponding to a loss in ammonia production
malfunction
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absence of this enzyme impairs the growth of Listeria under mild acidic conditions at pH 4.8 and reduced its survival in synthetic human gastric fluid at pH 2.5, corresponding to a loss in ammonia production
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physiological function
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Lmo0036 is responsible for acid tolerance at both sublethal and lethal pH levels and plays a possible role in Listeria virulence
physiological function
the enzyme generates carbamoyl phosphate for ATP production in the fermentative catabolism of agmatine
physiological function
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Lmo0036 is responsible for acid tolerance at both sublethal and lethal pH levels and plays a possible role in Listeria virulence
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additional information
sequence 230YGLY233 is the putrescine signature sequence
additional information
the C-terminal helix is essential for both formation of the functional trimer and catalytic activity, since truncated PTCase without the C-terminal helix aggregates and has only 3% of native catalytic activity. Active site structure, overview
additional information
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the C-terminal helix is essential for both formation of the functional trimer and catalytic activity, since truncated PTCase without the C-terminal helix aggregates and has only 3% of native catalytic activity. Active site structure, overview
additional information
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the C-terminal helix is essential for both formation of the functional trimer and catalytic activity, since truncated PTCase without the C-terminal helix aggregates and has only 3% of native catalytic activity. Active site structure, overview
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