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2.1.3.9: N-acetylornithine carbamoyltransferase

This is an abbreviated version!
For detailed information about N-acetylornithine carbamoyltransferase, go to the full flat file.

Word Map on EC 2.1.3.9

Reaction

Carbamoyl phosphate
+
N2-Acetyl-L-ornithine
=
phosphate
 +
N-acetyl-L-citrulline

Synonyms

acetylornithine transcarbamylase, AOTC, AOTCase, MJ0366, More, N-acetyl-L-ornithine transcarbamylase, N-acetylornithine carbamoyltransferase, N-acetylornithine transcarbamoylase, N-acetylornithine transcarbamylase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.3 Carboxy- and carbamoyltransferases
                2.1.3.9 N-acetylornithine carbamoyltransferase

Engineering

Engineering on EC 2.1.3.9 - N-acetylornithine carbamoyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K302A
site-directed mutagenesis, the mutant shows slightly reduced activity compared to the wild-type enzyme
K302E
site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme. The side-chain of Glu302 in the K302E mutant structure is well defined and anchored by hydrogen bonding interaction with the main-chain nitrogen atom of Arg298 and weakly hydrogen bonded to the main-chain nitrogen atom of Ser253
K302R
site-directed mutagenesis, the mutant shows highly reduced activity compared to the wild-type enzyme
additional information
computer model of molecular dynamic