2.2.1.11: 6-deoxy-5-ketofructose 1-phosphate synthase

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For detailed information about 6-deoxy-5-ketofructose 1-phosphate synthase, go to the full flat file.

Reaction

1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate

Synonyms

DKFP synthase, MJ1585, MM0714, MMP0293

ECTree

2 Transferases

2.2 Transferring aldehyde or ketonic groups

2.2.1 Transketolases and transaldolases

2.2.1.11 6-deoxy-5-ketofructose 1-phosphate synthase

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Results	in table
11	AA Sequence
3	Cloned(Commentary)
1	General Information
5	Natural Substrates/ Products (Substrates)
3	Organism
6	Pathway
1	pH Optimum
2	Reaction
3	Reference
5	Substrates and Products (Substrate)
7	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

General Information

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General Information on EC 2.2.1.11 - 6-deoxy-5-ketofructose 1-phosphate synthase

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metabolism

Methanocaldococcus jannaschii

Q58980

the enzyme is required in the biosynthetic pathway for creating 6-deoxy-5-ketofructose 1-phosphate, DKFP, a precursor sugar for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii. This pathway is not leading via the nucleoside diphosphate mannose pathway nor a pathway involving nucleoside diphosphate derivatives of fructose 1-phosphate, fructose 2-phosphate, or fructose 1,6-bisphosphate, but methylglyoxal and a fructose 1-phosphate- or fructose 1,6-bisphosphate-derived dihydroxyacetone phosphate fragment are key intermediates in DKFP production, detailed overview. The stereochemistry of the aldolase reaction is consistent with MJ1585 also functioning as the fructose 1,6-bisphosphate aldolase, EC 4.1.2.13, used in glycolysis. The MJ1585 aldolase does not catalyze the reaction of DL-lactaldehyde with fructose 1-phosphate, fructose 1,6-phosphate, or DHAP to form 6-deoxyallulose 1-phosphate or fuculose 1-phosphate

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