2.2.1.12: 3-acetyloctanal synthase

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For detailed information about 3-acetyloctanal synthase, go to the full flat file.

Reaction

Synonyms

pigD

ECTree

     2 Transferases

         2.2 Transferring aldehyde or ketonic groups

             2.2.1 Transketolases and transaldolases

                2.2.1.12 3-acetyloctanal synthase

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3	AA Sequence
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3	Cofactor
1	General Information
3	Natural Substrates/ Products (Substrates)
4	Organism
4	Pathway
1	pH Optimum
1	Purification (Commentary)
1	Reaction
4	Reference
25	Substrates and Products (Substrate)
5	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.2.1.12 - 3-acetyloctanal synthase

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SYSTEMATIC NAME

IUBMB Comments

pyruvate:(E)-oct-2-enal acetaldehydetransferase (decarboxylating)

Requires thiamine diphosphate. The enzyme, characterized from the bacterium Serratia marcescens, participates in the biosynthesis of the antibiotic prodigiosin. The enzyme decarboxylates pyruvate, followed by attack of the resulting two-carbon fragment on (E)-oct-2-enal, resulting in a Stetter reaction. In vitro the enzyme can act on a number of alpha,beta-unsaturated carbonyl compounds, including aldehydes and ketones, and can catalyse both 1-2 and 1-4 carboligations depending on the substrate.