2.2.1.5: 2-hydroxy-3-oxoadipate synthase

This is an abbreviated version!
For detailed information about 2-hydroxy-3-oxoadipate synthase, go to the full flat file.

Word Map on EC 2.2.1.5

2.2.1.5

thiamin

acetaldehyde

benzaldehyde

diphosphate-dependent

carboligation

thdp-dependent

zymomonas

r-phenylacetylcarbinol

mobilis

benzoylformate

hyperoxaluria

utilis

r-benzoin

enamine

1',4'-iminopyrimidine

thdp-bound

thiamine-deficient

medicine

synthesis

Reaction

Synonyms

(R)-HOA synthase, 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating), 2-hydroxy-3-oxoadipate synthase, 2-oxoglutarate: glyoxylate carboligase, alpha-ketoglutarate:glyoxylate carboligase, alpha-ketoglutaric-glyoxylic carboligase, carboligase, EC 4.1.3.15, glyoxylate-2-oxoglutarate carboligase, HOA synthase, HOAS, oxoglutarate: glyoxylate carboligase, Rv1248c

ECTree

2 Transferases

2.2 Transferring aldehyde or ketonic groups

2.2.1 Transketolases and transaldolases

2.2.1.5 2-hydroxy-3-oxoadipate synthase

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Results	in table
4	Activating Compound
566	AA Sequence
3	Application
1	CAS Registry Number
1	Cloned(Commentary)
18	Cofactor
3	General Information
3	General Stability
2	IC50 Value
11	Inhibitors
2	kcat/KM [mM/s]
2	Ki Value [mM]
8	KM Value [mM]
11	Localization
11	Metals/Ions
14	Natural Substrates/ Products (Substrates)
406	Organism
1	Oxidation Stability
1	Pathway
44	PDB ID
13	pH Optimum
1	pH Range
5	Purification (Commentary)
3	Reaction
1	Reaction Type
25	Reference
21	Source Tissue
8	Specific Activity [micromol/min/mg]
2	Storage Stability
51	Substrates and Products (Substrate)
27	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Stability [°C]
2	Turnover Number [1/s]

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Application on EC 2.2.1.5 - 2-hydroxy-3-oxoadipate synthase

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medicine

2 entries

synthesis

Escherichia coli

P0AFG3

application of the E1 component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex in the synthesis of chiral ompounds with multiple functional groups in good yield and high enantiomeric excess, by varying both the donor substrate (different 2-oxo acids) and the acceptor substrate (glyoxylate, ethyl glyoxylate and methyl glyoxal). The enzyme can accept 2-oxovalerate and 2-oxoisovalerate in addition to its natural substrate 2-oxoglutarate, and the tested acceptors are also acceptable in the carboligation reaction

736654