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2.2.1.5: 2-hydroxy-3-oxoadipate synthase

This is an abbreviated version!
For detailed information about 2-hydroxy-3-oxoadipate synthase, go to the full flat file.

Word Map on EC 2.2.1.5

Reaction

2-oxoglutarate
+
glyoxylate
=
2-hydroxy-3-oxoadipate
 +
CO2

Synonyms

(R)-HOA synthase, 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating), 2-hydroxy-3-oxoadipate synthase, 2-oxoglutarate: glyoxylate carboligase, alpha-ketoglutarate:glyoxylate carboligase, alpha-ketoglutaric-glyoxylic carboligase, carboligase, EC 4.1.3.15, glyoxylate-2-oxoglutarate carboligase, HOA synthase, HOAS, oxoglutarate: glyoxylate carboligase, Rv1248c

ECTree

     2 Transferases
         2.2 Transferring aldehyde or ketonic groups
             2.2.1 Transketolases and transaldolases
                2.2.1.5 2-hydroxy-3-oxoadipate synthase

Reference

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Reference on EC 2.2.1.5 - 2-hydroxy-3-oxoadipate synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hirabayashi, T.; Harada, T.
Inhibition of the alpha-ketoglutarate dehydrogenase complex from baker's yeast by acetaldehyde and glyoxylate
Agric. Biol. Chem.
36
1249-1251
1972
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
O'Fallon, J.V.; Brosemer, R.W.
Cellular localization of alpha-ketoglutarate: glyoxylate carboligase in rat tissues
Biochim. Biophys. Acta
499
321-328
1977
Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Zaror-Behrens, G.; Mavrides, C.
Further studies on 2-oxoglutarate:glyoxylate carboligase activity in Tetrahymena pyriformis
Int. J. Biochem.
7
111-116
1976
Tetrahymena pyriformis
-
Manually annotated by BRENDA team
Zaror-Behrens, G.; Mavrides, C.
Demonstration of 2-oxoglutarate:glyoxylate carboligase activity in Tetrahymena pyriformis
Can. J. Biochem.
51
1505-1508
1973
Tetrahymena pyriformis
Manually annotated by BRENDA team
Yamasaki, H.; Moriyama, T.
Purification, general properties and two other catalytic activities of alpha-ketoglutarate:glyoxylate carboligase of Mycobacterium phlei
Biochim. Biophys. Acta
242
637-647
1971
Mycolicibacterium phlei
Manually annotated by BRENDA team
Schlossberg, M.A.; Bloom, R.J.; Richert, D.A.; Westerfeld, W.W.
Carboligase activity of alpha-ketoglutarate dehydrogenase
Biochemistry
9
1148-1153
1970
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
Schlossberg, M.A.; Richert, D.A.; Bloom, R.J.; Westerfeld, W.W.
Isolation and identification of 5-hydroxy-4-ketovaleric acid as a product of alpha-ketoglutarate:glyoxylate carboligase
Biochemistry
7
333-337
1968
Bos taurus
Manually annotated by BRENDA team
Steward, P.R.; Quale, J.R.
The synergistic decarboxylation of glyoxylate and 2-oxoglutarate by an enzyme system from pig-liver mitochondria
Biochem. J.
102
885-897
1967
Sus scrofa
Manually annotated by BRENDA team
Rattan, V.; Thind, S.K.; Jethi, R.J.; Sidhu, H.; Nath, R.
Oxalate metabolism in magnesium-deficient rats
Magnes. Res.
6
127-133
1993
Rattus norvegicus
Manually annotated by BRENDA team
Yamasaki, H.; Mariyama, T.
alpha-Ketoglutarate:glyoxylate carboligase activity in Escherichia coli
Biochem. Biophys. Res. Commun.
39
790-795
1970
Escherichia coli
Manually annotated by BRENDA team
Sidhu, H.; Gupta, R.; Thind, S.K.; Nath, R.
Oxalate metabolism in thiamine-deficient rats
Ann. Nutr. Metab.
31
354-361
1987
Rattus norvegicus
Manually annotated by BRENDA team
Prather, C.W.; Sisler, E.C.
Glycine and glyoxylate decarboxylation in Nicotiana rustica roots
Phytochemistry
11
1637-1647
1972
Nicotiana rustica
-
Manually annotated by BRENDA team
Bats, R.; Rofe, A.M.; Conyers, R.A.J.
Investigations into the effect of glyoxylate decarboxylation and transamination on oxalate formation in rat
Nephron
57
460-469
1991
Rattus norvegicus
Manually annotated by BRENDA team
Dills, W.L., Jr.; Chen, P.; Baillargeon, B.M.; Westgate, C.L.
High pressure liquid chromatographic study of the glyoxalate:2-ketoglutarate carboligase reaction
Biochem. Arch.
15
279-284
1999
Bos taurus
-
Manually annotated by BRENDA team
de Carvalho, L.P.; Zhao, H.; Dickinson, C.E.; Arango, N.M.; Lima, C.D.; Fischer, S.M.; Ouerfelli, O.; Nathan, C.; Rhee, K.Y.
Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase
Chem. Biol.
17
323-332
2010
Mycobacterium tuberculosis (P9WIS5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIS5)
Manually annotated by BRENDA team
Zhao, H.; de Carvalho, L.P.; Nathan, C.; Ouerfelli, O.
A protecting group-free synthesis of deazathiamine: a step toward inhibitor design
Bioorg. Med. Chem. Lett.
20
6472-6474
2010
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Balakrishnan, A.; Jordan, F.; Nathan, C.F.
Influence of allosteric regulators on individual steps in the reaction catalyzed by Mycobacterium tuberculosis 2-hydroxy-3-oxoadipate synthase
J. Biol. Chem.
288
21688-21702
2013
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team
Patel, H.; Shim, D.; Farinas, E.; Jordan, F.
Investigation of the donor and acceptor range for chiral carboligation catalyzed by the E1 component of the 2-oxoglutarate dehydrogenase complex
J. Mol. Catal. B
98
42-45
2013
Escherichia coli (P0AFG3)
-
Manually annotated by BRENDA team
Maksymiuk, C.; Ioerger, T.; Balakrishnan, A.; Bryk, R.; Rhee, K.; Sacchettini, J.; Nathan, C.
Comparison of transposon and deletion mutants in Mycobacterium tuberculosis The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase
Tuberculosis
95
689-694
2015
Mycobacterium tuberculosis, Mycobacterium tuberculosis CDC1551, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team