2.2.1.5: 2-hydroxy-3-oxoadipate synthase
This is an abbreviated version!
For detailed information about 2-hydroxy-3-oxoadipate synthase, go to the full flat file.
Word Map on EC 2.2.1.5
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2.2.1.5
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thiamin
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acetaldehyde
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benzaldehyde
-
diphosphate-dependent
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carboligation
-
thdp-dependent
-
zymomonas
-
r-phenylacetylcarbinol
-
mobilis
-
benzoylformate
-
hyperoxaluria
-
utilis
-
r-benzoin
-
enamine
-
1',4'-iminopyrimidine
-
thdp-bound
-
thiamine-deficient
-
medicine
-
synthesis
- 2.2.1.5
- thiamin
- acetaldehyde
- benzaldehyde
-
diphosphate-dependent
-
carboligation
-
thdp-dependent
-
zymomonas
-
r-phenylacetylcarbinol
- mobilis
- benzoylformate
- hyperoxaluria
- utilis
-
r-benzoin
-
enamine
-
1',4'-iminopyrimidine
-
thdp-bound
-
thiamine-deficient
- medicine
- synthesis
Reaction
Synonyms
(R)-HOA synthase, 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating), 2-hydroxy-3-oxoadipate synthase, 2-oxoglutarate: glyoxylate carboligase, alpha-ketoglutarate:glyoxylate carboligase, alpha-ketoglutaric-glyoxylic carboligase, carboligase, EC 4.1.3.15, glyoxylate-2-oxoglutarate carboligase, HOA synthase, HOAS, oxoglutarate: glyoxylate carboligase, Rv1248c
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Substrates Products
Substrates Products on EC 2.2.1.5 - 2-hydroxy-3-oxoadipate synthase
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REACTION DIAGRAM
2-oxoglutarate + ethyl glyoxylate
(R)-6-ethoxy-5-hydroxy-4,6-dioxohexanoic acid + CO2
-
81% enantiomeric excess
-
?
2-oxoglutarate + glyoxylate
(R)-2-hydroxy-3-oxoadipate + CO2
-
90% enantiomeric excess
-
?
2-oxoglutarate + methylglyoxal
(R)-5-hydroxy-4,6-dioxoheptanoic acid + CO2
-
83% enantiomeric excess
-
?
2-oxoisovalerate + ethyl glyoxylate
(S)-ethyl 2-hydroxy-4-methyl-3-oxopentanoic acid + CO2
-
81% enantiomeric excess
-
?
2-oxoisovalerate + glyoxylate
(S)-2-hydroxy-4-methyl-3-oxopentanoic acid + CO2
-
67% enantiomeric excess
-
?
2-oxoisovalerate + methylglyoxal
(S)-3-hydroxy-5-methylhexane-2,4-dione + CO2
-
more than 90% enantiomeric excess
-
?
2-oxovalerate + ethyl glyoxylate
(S)-ethyl 2-hydroxy-3-oxohexanoic acid + CO2
-
52% enantiomeric excess
-
?
2-oxovalerate + glyoxylate
(S)-2-hydroxy-3-oxohexanoic acid + CO2
-
96% enantiomeric excess
-
?
2-oxovalerate + methylglyoxal
(S)-3-hydroxyheptane-2,4-dione + CO2
-
81% enantiomeric excess
-
?
2-oxoglutarate
? + CO2
-
identical with 2-oxoglutarate decarboxylase
-
-
?
2-oxoglutarate + acetaldehyde
5-hydroxy-4-oxohexanoate + CO2
-
-
-
?
2-oxoglutarate + acetaldehyde
5-hydroxy-4-oxohexanoate + CO2
-
-
-
-
?
2-oxoglutarate + glyoxylate
2-hydroxy-3-oxoadipate + CO2
-
-
-
-
?
2-oxoglutarate + glyoxylate
2-hydroxy-3-oxoadipate + CO2
-
-
-
?
2-oxoglutarate + glyoxylate
2-hydroxy-3-oxoadipate + CO2
-
-
-
-
?
2-oxoglutarate + glyoxylate
2-hydroxy-3-oxoadipate + CO2
-
-
-
-
?
2-oxoglutarate + glyoxylate
2-hydroxy-3-oxoadipate + CO2
-
-
-
?
2-hydroxy-3-oxohexandioate + CO2
-
-
i. e. 2-hydroxy-3-oxoadipic acid
?
2-oxoglutarate + glyoxylate
2-hydroxy-3-oxohexandioate + CO2
-
-
also 2,3-dihydroxy-4-ketopimelic acid
?
2-oxoglutarate + glyoxylate
2-hydroxy-3-oxohexandioate + CO2
-
-
further decarboxylation leads to 5-hydroxy-4-ketovaleric acid
?
2-oxoglutarate + glyoxylate
2-hydroxy-3-oxohexandioate + CO2
-
-
further spontaneous decarboxylation in the presence of acid
?
2-oxoglutarate + glyoxylate
2-hydroxy-3-oxohexandioate + CO2
-
-
-
-
?
2-oxoglutarate + glyoxylate
2-hydroxy-3-oxohexandioate + CO2
-
-
-
-
?
2-oxoglutarate + glyoxylate
2-hydroxy-3-oxohexandioate + CO2
-
-
-
-
?
2-oxoglutarate + glyoxylate
2-hydroxy-3-oxohexandioate + CO2
-
-
i. e. 2-hydroxy-3-oxoadipic acid, further spontaneous decarboxylation in the presence of acid
?
?
-
possible 1-carbon source for nicotine synthesis
-
-
?
2-oxoglutarate + glyoxylate
?
-
important as diversion of glyoxylate from oxalate formation
-
-
?
2-oxoglutarate + glyoxylate
?
-
hypothesized 2-oxoglutarate regeneration cycle
-
-
?
?
-
catalyzing C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of a second substrate, glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA)
-
-
?
additional information
?
-
-
catalyzing C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of a second substrate, glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA)
-
-
?
additional information
?
-
Rv1248c catalyzes C-C bond formation between the activated aldehyde of alpha-ketoglutarate and the carbonyl of glyoxylate to yield 2-hydroxy-3-oxoadipate (HOA), which decomposes to 5-hydroxylevulinate
-
-
?
additional information
?
-
-
Rv1248c catalyzes C-C bond formation between the activated aldehyde of alpha-ketoglutarate and the carbonyl of glyoxylate to yield 2-hydroxy-3-oxoadipate (HOA), which decomposes to 5-hydroxylevulinate
-
-
?
additional information
?
-
enzyme catalyzes consumption of 2-oxoglutarate in a mycobacterial small molecule extract with matched production of 5-hydroxylevulinate (HLA) in a reaction predicted to require glyoxylate
-
-
?
additional information
?
-
-
enzyme catalyzes consumption of 2-oxoglutarate in a mycobacterial small molecule extract with matched production of 5-hydroxylevulinate (HLA) in a reaction predicted to require glyoxylate
-
-
?
additional information
?
-
catalyzing C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of a second substrate, glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA)
-
-
?
additional information
?
-
Rv1248c catalyzes C-C bond formation between the activated aldehyde of alpha-ketoglutarate and the carbonyl of glyoxylate to yield 2-hydroxy-3-oxoadipate (HOA), which decomposes to 5-hydroxylevulinate
-
-
?
additional information
?
-
enzyme catalyzes consumption of 2-oxoglutarate in a mycobacterial small molecule extract with matched production of 5-hydroxylevulinate (HLA) in a reaction predicted to require glyoxylate
-
-
?