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2.2.1.5: 2-hydroxy-3-oxoadipate synthase

This is an abbreviated version!
For detailed information about 2-hydroxy-3-oxoadipate synthase, go to the full flat file.

Word Map on EC 2.2.1.5

Reaction

2-oxoglutarate
+
glyoxylate
=
2-hydroxy-3-oxoadipate
+
CO2

Synonyms

(R)-HOA synthase, 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating), 2-hydroxy-3-oxoadipate synthase, 2-oxoglutarate: glyoxylate carboligase, alpha-ketoglutarate:glyoxylate carboligase, alpha-ketoglutaric-glyoxylic carboligase, carboligase, EC 4.1.3.15, glyoxylate-2-oxoglutarate carboligase, HOA synthase, HOAS, oxoglutarate: glyoxylate carboligase, Rv1248c

ECTree

     2 Transferases
         2.2 Transferring aldehyde or ketonic groups
             2.2.1 Transketolases and transaldolases
                2.2.1.5 2-hydroxy-3-oxoadipate synthase

Substrates Products

Substrates Products on EC 2.2.1.5 - 2-hydroxy-3-oxoadipate synthase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-oxoglutarate
? + CO2
show the reaction diagram
2-oxoglutarate + acetaldehyde
5-hydroxy-4-oxohexanoate + CO2
show the reaction diagram
2-oxoglutarate + ethyl glyoxylate
(R)-6-ethoxy-5-hydroxy-4,6-dioxohexanoic acid + CO2
show the reaction diagram
-
81% enantiomeric excess
-
?
2-oxoglutarate + glyoxylate
(R)-2-hydroxy-3-oxoadipate + CO2
show the reaction diagram
-
90% enantiomeric excess
-
?
2-oxoglutarate + glyoxylate
2-hydroxy-3-oxoadipate + CO2
show the reaction diagram
2-oxoglutarate + glyoxylate
2-hydroxy-3-oxohexandioate + CO2
show the reaction diagram
2-oxoglutarate + glyoxylate
?
show the reaction diagram
2-oxoglutarate + methylglyoxal
(R)-5-hydroxy-4,6-dioxoheptanoic acid + CO2
show the reaction diagram
-
83% enantiomeric excess
-
?
2-oxoisovalerate + ethyl glyoxylate
(S)-ethyl 2-hydroxy-4-methyl-3-oxopentanoic acid + CO2
show the reaction diagram
-
81% enantiomeric excess
-
?
2-oxoisovalerate + glyoxylate
(S)-2-hydroxy-4-methyl-3-oxopentanoic acid + CO2
show the reaction diagram
-
67% enantiomeric excess
-
?
2-oxoisovalerate + methylglyoxal
(S)-3-hydroxy-5-methylhexane-2,4-dione + CO2
show the reaction diagram
-
more than 90% enantiomeric excess
-
?
2-oxovalerate + ethyl glyoxylate
(S)-ethyl 2-hydroxy-3-oxohexanoic acid + CO2
show the reaction diagram
-
52% enantiomeric excess
-
?
2-oxovalerate + glyoxylate
(S)-2-hydroxy-3-oxohexanoic acid + CO2
show the reaction diagram
-
96% enantiomeric excess
-
?
2-oxovalerate + methylglyoxal
(S)-3-hydroxyheptane-2,4-dione + CO2
show the reaction diagram
-
81% enantiomeric excess
-
?
additional information
?
-