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2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase

This is an abbreviated version!
For detailed information about 1-deoxy-D-xylulose-5-phosphate synthase, go to the full flat file.

Word Map on EC 2.2.1.7

Reaction

pyruvate
+
D-glyceraldehyde 3-phosphate
=
1-deoxy-D-xylulose 5-phosphate
 +
CO2

Synonyms

1-D-deoxy-D-threo-2-pentulose 5-phosphate synthetase, 1-D-deoxyxylulose 5-phosphate synthase, 1-deoxy-D-threo-pentulose synthase, 1-deoxy-D-xylulose 5-phosphate synthase, 1-deoxy-D-xylulose 5-phosphate synthase 1, 1-deoxy-D-xylulose 5-phosphate synthase 2, 1-deoxy-D-xylulose 5-phosphate synthetase, 1-deoxy-D-xylulose-5-phosphate pyruvate lyase, 1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxy-D-xylulose-5-phosphate synthase 1, 1-deoxy-D-xylulose-5-phosphate synthetase, 1-desoxy-D-xylulose-5-phosphate synthase, CSDXS, D-1-deoxyxylulose 5-phosphate synthase, deoxyxylulose 5-phosphate synthase, deoxyxylulose-5-phosphate synthase, deoxyxylulose-5-phosphate synthetase, DXP, DXP synthase, DXP-synthase, DXPase, DXPS, DXS, DXS-I, DXS-II, DXS1, dxs11, DXS2, DXS3, EC 4.1.3.37, GbDXS1, GbDXS2, glyceraldehydes 3-phosphate-pyruvate ligase, GmDXS1, MtDXS1, MtDXS2, OsDXS1, OsDXS2, OsDXS3, PaDXS1, PaDXS2A, PaDXS2B, PdDXS1, PdDXS2, synthase, 1-deoxy-D-xylulose 5-phosphate

ECTree

     2 Transferases
         2.2 Transferring aldehyde or ketonic groups
             2.2.1 Transketolases and transaldolases
                2.2.1.7 1-deoxy-D-xylulose-5-phosphate synthase

Inhibitors

Inhibitors on EC 2.2.1.7 - 1-deoxy-D-xylulose-5-phosphate synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1E,1'E)-O,O'-(ethane-1,2-diyl)bis[2,4,5-trihydroxybenzaldehyde oxime]
-
-
(1E,7E)-1-(2,4,5-trihydroxyphenyl)-3,6-dioxa-2,7-diazanona-1,7-dien-9-oate
-
-
(2R)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)-3-(4-hydroxyphenyl)propanoate
-
-
(2R)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)-3-phenylpropanoate
-
most potent selective inhibitor
(2R)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)propanoate
-
-
(2S)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)-3-(4-hydroxyphenyl)propanoate
-
-
(2S)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)-3-phenylpropanoate
-
-
(2S)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)propanoate
-
-
(E)-2,4,5-trihydroxybenzaldehyde O-benzyl oxime
-
-
(E)-2,4,5-trihydroxybenzaldehyde O-methyl oxime
-
-
(E)-2,4,5-trihydroxybenzaldehyde oxime
-
-
(E)-2,4-dihydroxybenzaldehyde O-methyl oxime
-
-
(E)-2,5-dihydroxybenzaldehyde O-methyl oxime
-
-
(E)-2-fluoro-4,5-dihydroxybenzaldehyde O-methyl oxime
-
-
(E)-2-fluoro-4,5-dimethoxybenzaldehyde O-methyl oxime
-
-
(E)-2-hydroxy-3-nitrobenzaldehyde O-methyl oxime
-
-
(E)-2-hydroxybenzaldehyde O-methyl oxime
-
-
(E)-3,4,5-trihydroxybenzaldehyde O-methyl oxime
-
-
(E)-3,4-dihydroxy-5-methoxybenzaldehyde O-methyl oxime
-
-
(E)-4,5-difluoro-2-hydroxybenzaldehyde O-methyl oxime
-
-
(E)-4-hydroxy-3-nitrobenzaldehyde O-methyl oxime
-
-
(E)-5-[(2-methylhydrazono)methyl]benzene-1,2,4-triol
-
-
(E)-uracil-6-carbaldehyde O-methyl oxime
-
-
(E,Z)-2,4,5-trimethoxybenzaldehyde O-methyl oxime
-
-
(E,Z)-3,4-dihydroxybenzaldehyde O-methyl oxime
-
-
1-deoxy-D-xylulose 5-phosphate
competitive inhibition with respect to pyruvate, non-competitive inhibition with respect to D-glyceraldehyde 3-phosphate
1-methyl-2-nitrosobenzene
weak inhibitory activity
1-nitrosonaphthalen-2-ol
weak inhibitory activity
2,3-diphospho-D-glyceric acid
-
0.1 mM, 50% inhibition
2-(1-benzyl-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate
-
-
2-(1-cyclohexyl-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate
-
-
2-(1-pentyl-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate
-
-
2-(1-[(2S)-1-[methyl(4-methylbenzene-1-sulfonyl)amino]-1-oxo-3-phenylpropan-2-yl]-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate
-
-
2-(1-[2-[methyl(methylsulfonyl)amino]-2-oxoethyl]-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate
-
-
2-methyl-3,5-diphenyl-6-propylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
2-methyl-3,5-diphenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
2-methyl-5-naphthalen-2-yl-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
2-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
-
2-[1-(2-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
-
2-[1-(2-methoxy-2-oxoethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
-
2-[1-(2-nitrobenzyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
-
2-[1-(2-phenylethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
-
2-[1-(2-[methyl[(4-methylphenyl)sulfonyl]amino]-2-oxoethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
-
2-[1-(3-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
-
2-[1-(4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
-
2-[1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
-
2-[1-(carboxymethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
-
2-[1-(prop-2-en-1-yl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
-
2-[1-[4-(methoxycarbonyl)benzyl]-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
-
3,5-bis(4-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
3,5-dimethyl-4-nitroso-1-(propan-2-yl)-1H-pyrazole
weak inhibitory activity
3,5-diphenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
3-(4-bromophenyl)-5-(2-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
3-(4-bromophenyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
3-(4-chlorophenyl)-2-ethyl-5-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
3-(4-chlorophenyl)-2-methyl-5-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
3-(4-chlorophenyl)-2-methyl-5-[[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl]pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
3-(4-chlorophenyl)-5-(4-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
3-(4-chlorophenyl)-5-(methoxymethyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
3-(4-chlorophenyl)-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
3-(4-chlorophenyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
3-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
3-(4-chlorophenyl)-5-[[(4-chlorophenyl)sulfanyl]methyl]-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
3-(4-fluorophenyl)-5-(4-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
3-(4-methoxyphenyl)-2-methyl-5-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
3-(4-methoxyphenyl)-5-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
3-fluoro-2-oxopropanoate
3-Fluoropyruvate
competitive with respect to pyruvate
5-(chloromethyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
5-benzyl-3-(4-chlorophenyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
5-benzyl-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
5-benzyl-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
5-[(methoxyamino)methyl]benzene-1,2,4-triol
-
-
5-[[(4-chlorophenyl)sulfanyl]methyl]-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
6-benzyl-3-(4-chlorophenyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
-
6-bromo-1-nitrosonaphthalen-2-ol
weak inhibitory activity
6-hydroxy-5-nitrosonaphthalene-2-sulfonamide
weak inhibitory activity
7-methoxy-1-nitrosonaphthalen-2-ol
weak inhibitory activity
benzylacetylphosphonate
beta-fluoropyruvate
beta-Glycerophosphate
-
0.3 mM, 40% inhibition
butyl acetyl phosphonate
-
-
butylacetylphosphonate
-
-
D-3-phosphoglyceric acid
-
0.16 mM, 23% inhibition
D-glyceraldehyde
-
competitive inhibition with respect to pyruvate
D-glyceraldehyde 3-phosphate
-
substrate inhibition
dimethylallyl diphosphate
-
competitive inhibitor
DL-alpha-glycerophosphate
-
0.29 mM, 50% inhibition
ethyl (5-methyl-7-oxo-3-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)acetate
-
-
ethyl acetylphosphonate
-
-
Fluoropyruvate
-
recombinant protein, 50% inhibition at 0.4 mM, fluoropyruvate is supposed to bind covalently to the active site
hexyl acetylphosphonate
-
-
isopentenyl diphosphate
-
competitive inhibitor
isopropylacetylphosphonate
-
weak inhibition
ketoclomazone
-
-
lithium but-3-yn-1-yl acetylphosphonate
-
-
methyl acetylphosphonate
-
-
methyl [3-(4-bromophenyl)-7-oxo-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-5-yl]acetate
-
-
Methylacetylphosphonate
N,N-dimethyl-4-nitrosoaniline
weak inhibitory activity
nitrosobenzene
weak inhibitory activity
octyl acetylphosphonate
-
-
pentyl acetylphosphonate
-
-
phosphonoacetohydroxamate
-
0.1 mM, 25% inhibition
phosphonopropionohydroxamate
-
0.1 mM, 10% inhibition
propyl acetylphosphonate
-
-
pyruvate
-
substrate inhibition
additional information
-