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2.2.1.9: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase

This is an abbreviated version!
For detailed information about 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase, go to the full flat file.

Word Map on EC 2.2.1.9

Reaction

isochorismate
+
2-oxoglutarate
=
5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate
 +
CO2

Synonyms

(1R,2S,5S,6S)-2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, (1R,2S,5S,6S)-2-succinyl-5-enolpyruvyl-6-hydroxycyclohex-3-ene-1-carboxylate synthase, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid synthase, EC 2.5.1.64, EcMenD, MenD, Rv0555, SEPHCHC synthase, SHCHC synthase

ECTree

     2 Transferases
         2.2 Transferring aldehyde or ketonic groups
             2.2.1 Transketolases and transaldolases
                2.2.1.9 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase

Reference

topprint

Reference on EC 2.2.1.9 - 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sieminska, E.A.; Macova, A.; Palmer, D.R.; Sanders, D.A.
Crystallization and preliminary X-ray analysis of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) synthase (MenD) from Escherichia coli
Acta Crystallogr. Sect. F
61
489-492
2005
Escherichia coli
Manually annotated by BRENDA team
Jiang, M.; Cao, Y.; Guo, Z.F.; Chen, M.; Chen, X.; Guo, Z.
Menaquinone biosynthesis in Escherichia coli: identification of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate as a novel intermediate and re-evaluation of MenD activity
Biochemistry
46
10979-10989
2007
Escherichia coli
Manually annotated by BRENDA team
Priyadarshi, A.; Saleem, Y.; Nam, K.H.; Kim, K.S.; Park, S.Y.; Kim, E.E.; Hwang, K.Y.
Structural insights of the MenD from Escherichia coli reveal ThDP affinity
Biochem. Biophys. Res. Commun.
380
797-801
2009
Escherichia coli K-12 (P17109)
Manually annotated by BRENDA team
Dawson, A.; Fyfe, P.K.; Hunter, W.N.
Specificity and reactivity in menaquinone biosynthesis: the structure of Escherichia coli MenD (2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase)
J. Mol. Biol.
384
1353-1368
2008
Escherichia coli K-12 (P17109)
Manually annotated by BRENDA team
Kurutsch, A.; Richter, M.; Brecht, V.; Sprenger, G.; Müller, M.
MenD as a versatile catalyst for asymmetric synthesis
J. Mol. Catal. B
61
56-66
2009
Escherichia coli K-12
-
Manually annotated by BRENDA team
Fang, M.; Macova, A.; Hanson, K.L.; Kos, J.; Palmer, D.R.
Using substrate analogues to probe the kinetic mechanism and active site of Escherichia coli MenD
Biochemistry
50
8712-8721
2011
Escherichia coli, Mycobacterium tuberculosis
Manually annotated by BRENDA team
Dawson, A.; Chen, M.; Fyfe, P.K.; Guo, Z.; Hunter, W.N.
Structure and reactivity of Bacillus subtilis MenD catalyzing the first committed step in menaquinone biosynthesis
J. Mol. Biol.
401
253-264
2010
Bacillus subtilis (P23970), Bacillus subtilis
Manually annotated by BRENDA team
Song, H.; Dong, C.; Qin, M.; Chen, Y.; Sun, Y.; Liu, J.; Chan, W.; Guo, Z.
A thiamine-dependent enzyme utilizes an active tetrahedral intermediate in vitamin K biosynthesis
J. Am. Chem. Soc.
138
7244-7247
2016
Escherichia coli (P17109)
Manually annotated by BRENDA team
Qin, M.; Song, H.; Dai, X.; Chen, Y.; Guo, Z.
Two active site arginines are critical determinants of substrate binding and catalysis in MenD a thiamine-dependent enzyme in menaquinone biosynthesis
Biochem. J.
475
3651-3667
2018
Escherichia coli (P17109)
Manually annotated by BRENDA team
Fries, A.; Mazzaferro, L.S.; Gruening, B.; Bisel, P.; Stibal, K.; Buchholz, P.C.F.; Pleiss, J.; Sprenger, G.A.; Mueller, M.
Alteration of the route to menaquinone towards isochorismate-derived metabolites
ChemBioChem
20
1672-1677
2019
Escherichia coli (P17109)
Manually annotated by BRENDA team
Bashiri, G.; Nigon, L.V.; Jirgis, E.N.M.; Ho, N.A.T.; Stanborough, T.; Dawes, S.S.; Baker, E.N.; Bulloch, E.M.M.; Johnston, J.M.
Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogen Mycobacterium tuberculosis
J. Biol. Chem.
295
3759-3770
2020
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team
Xu, J.; Yan, W.; Zhang, W.
Enhancing menaquinone-7 production in recombinant Bacillus amyloliquefaciens by metabolic pathway engineering
RSC Adv.
7
28527-28534
2017
Bacillus amyloliquefaciens, Bacillus amyloliquefaciens W-21
-
Manually annotated by BRENDA team
Jirgis, E.N.; Bashiri, G.; Bulloch, E.M.; Johnston, J.M.; Baker, E.N.
Structural views along the Mycobacterium tuberculosis MenD reaction pathway illuminate key aspects of thiamin diphosphate-dependent enzyme mechanisms
Structure
24
1167-1177
2016
Mycobacterium tuberculosis (P9WK11), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WK11)
Manually annotated by BRENDA team