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2.3.1.1: amino-acid N-acetyltransferase

This is an abbreviated version!
For detailed information about amino-acid N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.1

Reaction

acetyl-CoA
+
L-glutamate
=
CoA
 +
N-acetyl-L-glutamate

Synonyms

acetylglutamate synthase, acetylglutamate synthetase, acetylglutamic synthetase, acetyltransferase, amino acid, AGAS, amino acid acetyltransferase, ARG2, ArgA, ArgH(A), argJ, Cg3035, More, N-acetyl-glutamate synthase, N-acetyl-L-glutamate synthase, N-acetyl-L-glutamate synthase/kinase, N-acetyl-L-glutamate synthetase, N-acetylglutamate synthase, N-acetylglutamate synthase/kinase, N-acetylglutamate synthetase, NAGS, NAGS-K, NAGS/K, NAT, ngNAGS, PaNAGS, pitax, Rv2747, SINAGS1, XcNAGS

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.1 amino-acid N-acetyltransferase

Specific Activity

Specific Activity on EC 2.3.1.1 - amino-acid N-acetyltransferase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000135
-
activity in liver of fetus, activity increases strongly after eating external diets until week 10 after birth
0.0000136
-
activity in intestine of fetus
0.000014
-
-
0.0000203
-
activity in intestine at day 3 after birth
0.0000455
-
activity in intestine of adult
0.0000643
-
activity in intestine at day 1 after birth
0.00013
0.000268
0.002
0.00286
-
-
0.053
-
purified recombinant His-tagged enzyme, in absence of L-arginine
0.078
mutant enzyme Y485F, at pH 8.5 and 30°C
0.081
-
purified recombinant His-tagged enzyme, in presence of L-arginine
0.098
-
wild-type
0.136
-
wild-type + 1 mM arginine
0.139
-
purified recombinant His-tagged enzyme in 10fold dilution, in absence of L-arginine
0.154
mutant enzyme N479A, at pH 8.5 and 30°C
0.163
-
purified recombinant His-tagged enzyme in 10fold dilution, in presence of L-arginine
0.325
-
purified recombinant His-tagged enzyme in 50fold dilution, in absence of L-arginine
0.346
mature recombinant enzyme in the absence of arginine
0.359
-
purified recombinant His-tagged enzyme in 50fold dilution, in presence of L-arginine
0.438
-
wild-type
0.528
-
wild-type + 1 mM arginine
0.572
-
wild-type + 1mM arginine
0.803
mature recombinant enzyme in the presence of 1 mM arginine
0.857
mutant enzyme Y441F, at pH 8.5 and 30°C
1.05
wild type enzyme, at pH 8.5 and 30°C
1.84
-
wild-type + 1mM arginine
10.64
-
wild-type
111.7
-
wild-type
114.9
-
mutant delQ284
12.22
-
mutant F121C
12.27
-
wild-type
12.57
13
-
mutant G360P
13.08
-
mutant F121C + 1 mM arginine
15.28
-
mutant E354A + 1 mM arginine
15.47
-
mutant E354A
15.89
-
wild-type + 1 mM arginine
20.88
-
wild-type
24
-
mutant delE283delQ284
25.56
-
wild-type + 1 mM arginine
26.68
26.93
-
mutant E280A
3.19
-
mutant G362S + 1 mM arginine
3.22
-
mutant G362S
3.51
-
mutant G286P
4.4
residual activity at inhibition by L-arginine
4.97
mutant enzyme S387A, at pH 8.5 and 30°C
42.55
43.6
-
mutant ins284Ains285A
46.04
-
mutant G288S
48.8
-
mutant ins284A
5.475
-
wild-type + 1 mM arginine
5.85
-
wild-type
6.81
wild type enzyme, at pH 8.5 and 30°C
62
-
wild-type
79.4
-
wild-type enzyme
9.11
-
wild-type
9.66
-
mutant F35C
92.4
-
in the presence of 1 mM L-arginine
additional information