2.3.1.108: alpha-tubulin N-acetyltransferase
This is an abbreviated version!
For detailed information about alpha-tubulin N-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.108
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2.3.1.108
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trna
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histone
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chromatin
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anticodons
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wobble
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trnamet
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microtubule
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dysautonomia
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aminoacylated
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formylation
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cbp
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aminoacyl-trnas
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kluyveromyces
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zymocin
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methionyl-trna
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ikbkap
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trnaphe
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nua4
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rnapii
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six-subunit
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p-site
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non-histone
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complex-associated
- 2.3.1.108
- trna
- histone
- chromatin
-
anticodons
-
wobble
- trnamet
- microtubule
- dysautonomia
-
aminoacylated
-
formylation
- cbp
- aminoacyl-trnas
- kluyveromyces
-
zymocin
- methionyl-trna
-
ikbkap
- trnaphe
- nua4
- rnapii
-
six-subunit
-
p-site
-
non-histone
-
complex-associated
Reaction
Synonyms
acetyl-CoA:alpha-tubulin-L-lysine Ne-acetyltransferase, alpha-TAT, alpha-tubulin acetylase, alpha-tubulin acetyltransferase, alpha-tubulin K40 acetyltransferase, alpha-tubulin N-acetyltransferase 1, alphaTAT, alphaTAT1, alphaTAT2, ATAT-2, ATAT1, ATAT1 acetylase, ATAT1 tubulin acetyltransferase, elongator, KAT, lysine acetyltransferase, Mec-17, TAT, tubulin acetyltransferase
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Localization
Localization on EC 2.3.1.108 - alpha-tubulin N-acetyltransferase
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Golgi aparatus of spermatocytes and spermatids of testis
additional information
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acetylation of alpha-tubulin K40 by alphaTAT1 inside the microtubule lumen
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enzyme acetylated both dimers and polymers of tubulin
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2fold preference for polymerized versus soluble tubulin
alphaTaT1 enters the microtubule lumen through the microtubule ends, and through bends or breaks in the lattice. AlphaTat1 is concentrated near th microtubule ends
ATAT1 dramatically changes its localization through the cell cycle, depending on the mitotic phase. In interphase, immunolabeled ATAT1 is observed in centrioles, nuclei, and basal bodies if the cells projected primary cilia. ATAT1 is intensely detected as clusters in the nuclei in the G1-G2 phase. In telophase, ATAT1 colocalizes with chromatids and spindle poles, and ultimately migrates to the daughter nucleus, newly synthesized centrioles, and midbody
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additional information
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ATAT1 dramatically changes its localization through the cell cycle, depending on the mitotic phase. In interphase, immunolabeled ATAT1 is observed in centrioles, nuclei, and basal bodies if the cells projected primary cilia. ATAT1 is intensely detected as clusters in the nuclei in the G1-G2 phase. In telophase, ATAT1 colocalizes with chromatids and spindle poles, and ultimately migrates to the daughter nucleus, newly synthesized centrioles, and midbody
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