2.3.1.111: mycocerosate synthase

This is an abbreviated version!
For detailed information about mycocerosate synthase, go to the full flat file.

Word Map on EC 2.3.1.111

2.3.1.111

mycobacterium

bovis

tuberculosis

synthases

smegmatis

polyketide

acyl-coa

phthiocerol

dimycocerosate

n-fatty

esterify

kolattukudy

methyl-branched

beta-ketoacyl

resequenced

hygromycin-resistant

synthase-like

crossover

iterative

phenolphthiocerol

fadd28

rainwater

slow-growing

Reaction

a long-chain acyl-[mycocerosic acid synthase]

+ 3 methylmalonyl-CoA + 6 NADPH + 6 H+ =

a trimethylated-mycocerosoyl-[mycocerosate synthase]

+ 3 CoA + 3 CO2 + 6 NADP⁺ + 3 H2O

Synonyms

mycocerosic acid synthase, Pks5

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.111 mycocerosate synthase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
377	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
1	Cofactor
1	Crystallization (Commentary)
1	General Stability
3	Inhibitors
3	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
8	Organism
2	Pathway
31	PDB ID
1	pH Optimum
4	Purification (Commentary)
2	Reaction
2	Reaction Type
8	Reference
1	Specific Activity [micromol/min/mg]
1	Storage Stability
12	Substrates and Products (Substrate)
2	Subunits
3	Synonyms
1	Systematic Name

Reference

top print

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Reference on EC 2.3.1.111 - mycocerosate synthase

Please use the Reference Search for a specific query.

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

486135

Rainwater, D.L.; Kolattokudy, P.E.

Fatty acid biosynthesis in Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guerin. Purification and characterization of a novel fatty acid synthase, mycocerosic acid synthase, which elongates n-fatty acyl-CoA with methylmalonyl-CoA

J. Biol. Chem.

260

616-623

1985

Mycobacterium tuberculosis, Mycolicibacterium smegmatis

3880746

486136

Mathur, M.; Kolattokudy, P.E.

Molecular cloning and sequencing of the gene for mycocerosic acid synthase, a novel fatty acid elongating multifunctional enzyme, from Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guerin

J. Biol. Chem.

267

19388-19395

1992

Mycobacterium tuberculosis

1527058

486137

Fitzmaurice, A.M.; Kolattukudy, P.E.

An acyl-CoA synthase (acoas) gene adjacent to the mycocerosic acid synthase (mas) locus is necessary for mycocerosyl lipid synthesis in Mycobacterium tuberculosis var. bovis BCG

J. Biol. Chem.

273

8033-8039

1998

Mycobacterium tuberculosis

9525903

486138

Fernandes, N.D.; Kolattukudy, P.E.

A newly identified methyl-branched chain fatty acid synthesizing enzyme from Mycobacterium tuberculosis var. bovis BCG

J. Biol. Chem.

273

2823-2828

1998

Mycobacterium tuberculosis

9446591

486139

Li, M.S.; Monahan, I.M.; Waddell, S.J.; Mangan, J.A.; Martin, S.L.; Everett, M.J.; Butcher, P.D.

cDNA-RNA subtractive hybridization reveals increased expression of mycocerosic acid synthase in intracellular Mycobacterium bovis BCG

Microbiology

147

2293-2305

2001

Mycobacterium tuberculosis

11496006

757799

Herbst, D.A.; Jakob, R.P.; Zaehringer, F.; Maier, T.

Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases

Nature

531

533-537

2016

Mycolicibacterium smegmatis (A0R1E8), Mycolicibacterium smegmatis, Mycolicibacterium smegmatis ATCC 700084 (A0R1E8)

26976449