2.3.1.117: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

This is an abbreviated version!
For detailed information about 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, go to the full flat file.

Reaction

Synonyms

DapD, Mtb-DapD, PA3666, succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase, succinyltransferase, tetrahydrodipicolinate, TabB, tetrahydrodipicolinate N-succinyltransferase, tetrahydrodipicolinate succinylase, tetrahydrodipicolinate succinyltransferase, tetrahydrodipicolinate-N-succinyltransferase, THDP

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.117 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

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Results	in table
21566	AA Sequence
1	Application
1	CAS Registry Number
7	Cloned(Commentary)
1	Cofactor
9	Crystallization (Commentary)
3	General Information
1	General Stability
1	IC50 Value
23	Inhibitors
2	kcat/KM [mM/s]
3	Ki Value [mM]
9	KM Value [mM]
5	Metals/Ions
5	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
15	Organism
6	Pathway
58	PDB ID
2	pH Optimum
1	pH Range
3	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
15	Reference
1	Specific Activity [micromol/min/mg]
2	Storage Stability
22	Substrates and Products (Substrate)
4	Subunits
17	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Turnover Number [1/s]

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Reference on EC 2.3.1.117 - 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

246566

Born, T.L.; Blanchard, J.S.

Structure/function studies on enzymes in the diaminopimelate pathway of bacterial cell wall biosynthesis

Curr. Opin. Chem. Biol.

3

607-613

1999

Escherichia coli, Mycobacterium tuberculosis variant bovis

10508663

brenda

486148

Simms, S.A.; Voige, W.H.; Gilvarg, C.

Purification and characterization of succinyl-CoA: tetrahydrodipicolinate N-succinyltransferase from Escherichia coli

J. Biol. Chem.

259

2734-2741

1984

Escherichia coli

6365916

brenda

486149

Berges, D.A.; DeWolf, W.E.; Dunn, G.L.; Newmann, D.J.; Schmidt, S.J.; Taggart, J.J.; Gilvarg, C.

Studies on the active site of succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase. Characterization using analogs of tetrahydrodipicolinate

J. Biol. Chem.

261

6160-6167

1986

Escherichia coli

3700390

brenda

486150

Beaman, T.W.; Binder, D.A.; Blanchard, J.S.; Roderick, S.L.

Three-dimensional structure of tetrahydrodipicolinate N-succinyltransferase

Biochemistry

36

489-494

1997

Mycobacterium tuberculosis variant bovis

9012664

brenda

486151

Beaman, T.W.; Blanchard, J.S.; Roderick, S.L.

The conformational change and active site structure of tetrahydrodipicolinate N-succinyltransferase

Biochemistry

37

10363-10369

1998

Mycobacterium tuberculosis variant bovis

9671504

brenda

486152

Shaw-Reid, C.A.; McCormick, M.M.; Sinskey, A.J.; Stephanopoulos, G.

Flux through the tetrahydrodipicolinate succinylase pathway is dispensable for L-lysine production in Corynebacterium glutamicum

Appl. Microbiol. Biotechnol.

51

325-333

1999

Corynebacterium glutamicum

10222581

brenda

486154

Beaman, T.W.; Vogel, K.W.; Drueckhammer, D.G.; Blanchard, J.S.; Roderick, S.L.

Acyl group specificity at the active site of tetrahydrodipicolinate N-succinyltransferase

Protein Sci.

11

974-979

2002

Mycobacterium tuberculosis variant bovis

11910040

brenda

684203

Schuldt, L.; Weyand, S.; Kefala, G.; Weiss, M.S.

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of tetrahydrodipicolinate-N-succinyltransferase (Rv1201c) from Mycobacterium tuberculosis

Acta Crystallogr. Sect. F

64

863-866

2008

Mycobacterium tuberculosis

18765924

brenda

686773

Nguyen, L.; Kozlov, G.; Gehring, K.

Structure of Escherichia coli tetrahydrodipicolinate N-succinyltransferase reveals the role of a conserved C-terminal helix in cooperative substrate binding

FEBS Lett.

582

623-626

2008

Escherichia coli (Q8X8Y7), Escherichia coli

18242192

brenda

705149

Schuldt, L.; Weyand, S.; Kefala, G.; Weiss, M.S.

The three-dimensional Structure of a mycobacterial DapD provides insights into DapD diversity and reveals unexpected particulars about the enzymatic mechanism

J. Mol. Biol.

389

863-879

2009

Mycobacterium tuberculosis (P9WP21), Mycobacterium tuberculosis

19394346

brenda

720852

Schnell, R.; Oehlmann, W.; Sandalova, T.; Braun, Y.; Huck, C.; Maringer, M.; Singh, M.; Schneider, G.

Tetrahydrodipicolinate N-succinyltransferase and dihydrodipicolinate synthase from Pseudomonas aeruginosa: structure analysis and gene deletion

PLoS ONE

7

e31133

2012

Pseudomonas aeruginosa

22359568

brenda

736292

Sagong, H.Y.; Kim, K.J.

Crystal structure and biochemical characterization of tetrahydrodipicolinate N-succinyltransferase from Corynebacterium glutamicum

J. Agric. Food Chem.

63

10641-10646

2015

Corynebacterium glutamicum (Q8NRE3), Corynebacterium glutamicum, Corynebacterium glutamicum DSM 20300 (Q8NRE3)

26602189

brenda

755963

Manning, M.E.; Danson, E.J.; Calderone, C.T.

Functional chararacterization of the enzymes TabB and TabD involved in tabtoxin biosynthesis by Pseudomonas syringae

Biochem. Biophys. Res. Commun.

496

212-217

2018

Pseudomonas amygdali pv. tabaci (P31852)

29307827

brenda

Entries 1 - 20 of 13

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