2.3.1.118: N-hydroxyarylamine O-acetyltransferase
This is an abbreviated version!
For detailed information about N-hydroxyarylamine O-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.118
-
2.3.1.118
-
typhimurium
-
n-acetyltransferase
-
nitroarenes
-
4-aminobiphenyl
-
glu-p-1
-
tester
-
1-nitropyrene
-
1,8-dinitropyrene
-
plant-activated
-
2-aminoanthracene
-
benzidine
-
polyguanylic
-
arylhydroxamic
-
beta-naphthylamine
-
2-amino-6-methyldipyrido1,2-a:3',2'-dimidazole
-
3-hydroxyamino-1-methyl-5h-pyrido4,3-bindole
-
genotype-independent
-
nitroaromatics
-
2-nitrofluorene
-
promutagens
-
m-phenylenediamine
-
o-acetylation
-
pentachlorophenol
- 2.3.1.118
- typhimurium
- n-acetyltransferase
-
nitroarenes
- 4-aminobiphenyl
-
glu-p-1
-
tester
- 1-nitropyrene
-
1,8-dinitropyrene
-
plant-activated
- 2-aminoanthracene
- benzidine
-
polyguanylic
-
arylhydroxamic
- beta-naphthylamine
-
2-amino-6-methyldipyrido1,2-a:3',2'-dimidazole
-
3-hydroxyamino-1-methyl-5h-pyrido4,3-bindole
-
genotype-independent
-
nitroaromatics
- 2-nitrofluorene
-
promutagens
- m-phenylenediamine
-
o-acetylation
- pentachlorophenol
Reaction
Synonyms
acetyltransferase, N-hydroxyarylamine O-, arylamine N-acetyltransferase, arylhydroxamate N,O-acetyltransferase, N-arylamine acetyltransferase, N-hydroxy-2-aminofluorene-O-acetyltransferase, N-hydroxyarylamine O-acetyltransferase, NhoA, NhoA1, NhoA2
ECTree
2.3.1.118 N-hydroxyarylamine O-acetyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.3.1.118 - N-hydroxyarylamine O-acetyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
N-acetyltransferase activity
-
?
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
acetyl-CoA + 3-amino-4-hydroxyphenylarsonic acid
CoA + N-acetyl-3-amino-4-hydroxyphenylarsonic acid
-
-
-
-
?
acetyl-CoA + 3-hydroxyamino-1-methyl-pyrido[4,3-b]-indole
CoA + N-acetoxy-amino-1-methyl-pyrido[4,3-b]-indole
acetyl-CoA + 4-aminoveratrole
CoA + N-acetyl-4-aminoveratrole
-
-
-
?
acetyl-CoA + 4-anisidine
CoA + N-acetyl-4-anisidine
-
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + N-acetyl-4-iodoaniline
-
-
-
?
acetyl-CoA + aniline
CoA + N-acetylaniline
-
N-acetyltransferase activity, ping-pong bi bi mechanism
-
?
acetyl-CoA + isoniazid
CoA + N-acetyl-isoniazid
-
N-acetyltransferase activity, ping-pong bi bi mechanism
-
?
acetyl-CoA + m-aminophenol
CoA + N-acetyl-m-aminophenol
-
N-acetyltransferase activity, ping-pong bi bi mechanism
-
?
acetyl-CoA + N-hydroxy-3,2'-dimethyl-4-aminobiphenyl
CoA + N-acetoxy-3,2'-dimethyl-4-aminobiphenyl
-
-
-
?
acetyl-CoA + o-aminophenol
CoA + N-acetyl-o-aminophenol
-
N-acetyltransferase activity, ping-pong bi bi mechanism
-
?
acetyl-CoA + o-anisidine
CoA + N-acetyl-o-anisidine
-
N-acetyltransferase activity, ping-pong bi bi mechanism
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
N-acetyltransferase activity, ping-pong bi bi mechanism
-
?
acetyl-CoA + p-aminophenol
CoA + N-acetyl-p-aminophenol
-
N-acetyltransferase activity, ping-pong bi bi mechanism
-
?
acetyl-CoA + p-aminotoluene
CoA + N-acetyl-p-aminotoluene
-
N-acetyltransferase activity, ping-pong bi bi mechanism
-
?
acetyl-CoA + p-anisidine
CoA + N-acetyl-p-anisidine
-
N-acetyltransferase activity, ping-pong bi bi mechanism
-
?
butyryl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-(butyryloxy)-6-methylpyrido[3',2':4,5]imidazo[1,2-a]pyridin-2-amine
hexanoyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-hexanoyloxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
1.3% of the activity compared to acetyl-CoA as acyl donor
-
?
malonyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-malonyloxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
propionyl-CoA + 2-hydroxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-propionyloxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
-
-
-
?
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
-
-
?
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
-
-
?
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
-
-
-
?
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
-
-
-
?
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
-
-
?
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
-
-
?
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
-
-
?
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
-
-
?
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
-
-
?
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
N-hydroxy-2-acetylaminofluorene cannot replace acetyl-CoA
-
?
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
-
-
?
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
N-hydroxy-2-acetylaminofluorene cannot replace acetyl-CoA
-
?
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
-
-
?
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
-
-
?
acetyl-CoA + 3-hydroxyamino-1-methyl-pyrido[4,3-b]-indole
CoA + N-acetoxy-amino-1-methyl-pyrido[4,3-b]-indole
-
-
-
?
acetyl-CoA + 3-hydroxyamino-1-methyl-pyrido[4,3-b]-indole
CoA + N-acetoxy-amino-1-methyl-pyrido[4,3-b]-indole
-
-
-
?
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
-
involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species
-
?
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
-
the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates
-
?
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
-
involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species
-
?
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
-
involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species
-
?
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
-
the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates
-
?
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
-
the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates
-
?
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
-
involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species
-
?
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
-
the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates
-
?
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
-
involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species
-
?
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
-
the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates
-
?
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
-
involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species
-
?
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
-
involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species
-
?
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
-
the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates
-
?
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
-
the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates
-
?
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
-
unknown endogenous substrate in bacteria
-
?
acetyl-CoA + N-hydroxy-2-aminofluorene
CoA + N-acetoxy-2-aminofluorene
-
-
-
?
acetyl-CoA + N-hydroxy-2-aminofluorene
CoA + N-acetoxy-2-aminofluorene
-
-
-
?
acetyl-CoA + N-hydroxy-2-aminofluorene
CoA + N-acetoxy-2-aminofluorene
-
-
-
?
acetyl-CoA + N-hydroxy-2-aminofluorene
CoA + N-acetoxy-2-aminofluorene
-
-
-
-
?
acetyl-CoA + N-hydroxy-2-aminofluorene
CoA + N-acetyloxy-2-aminofluorene
-
-
-
-
?
acetyl-CoA + N-hydroxy-2-aminofluorene
CoA + N-acetyloxy-2-aminofluorene
-
-
-
-
?
acetyl-CoA + N-hydroxy-4-aminobiphenyl
CoA + N-acetoxy-4-aminobiphenyl
-
-
-
?
acetyl-CoA + N-hydroxy-4-aminobiphenyl
CoA + N-acetoxy-4-aminobiphenyl
-
-
-
?
acetyl-CoA + N-hydroxy-4-aminobiphenyl
CoA + N-acetoxy-4-aminobiphenyl
-
-
-
?
acetyl-CoA + o-aminobenzoic acid
CoA + N-acetyl-o-aminobenzoic acid
-
N-acetyltransferase activity, ping-pong bi bi mechanism
-
?
acetyl-CoA + o-aminobenzoic acid
CoA + N-acetyl-o-aminobenzoic acid
-
o-aminobenzoic acid is intermediate in the synthesis of tryptophane in E. coli
-
?
butyryl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-(butyryloxy)-6-methylpyrido[3',2':4,5]imidazo[1,2-a]pyridin-2-amine
-
11% of the activity compared to acetyl-CoA as acyl donor
-
?
butyryl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-(butyryloxy)-6-methylpyrido[3',2':4,5]imidazo[1,2-a]pyridin-2-amine
-
11% of the activity compared to acetyl-CoA as acyl donor
-
?
malonyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-malonyloxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
19% of the activity compared to acetyl-CoA as acyl donor
-
?
malonyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-malonyloxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
19% of the activity compared to acetyl-CoA as acyl donor
-
?
propionyl-CoA + 2-hydroxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-propionyloxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
89% of the activity compared to acetyl-CoA as acyl donor
-
?
propionyl-CoA + 2-hydroxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
CoA + N-propionyloxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
89% of the activity compared to acetyl-CoA as acyl donor
-
?
additional information
?
-
-
no substrates of either isoform NhoA1 or NhoA2: 4-amino-phenylarsonic acid, 2-amino-phenylarsonic acid, and 4-carbamoylamino-phenylarsonic acid
-
-
-
additional information
?
-
-
the N-acetoxyarylamine products form covalent adducts with cellular macromolecules, e.g. tRNA
-
-
?
additional information
?
-
-
the N-acetoxyarylamine products form covalent adducts with cellular macromolecules, e.g. tRNA
-
-
?
