2.3.1.135: phosphatidylcholine-retinol O-acyltransferase

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For detailed information about phosphatidylcholine-retinol O-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.135

2.3.1.135

retinoids

retinal

all-trans-retinyl

opsin

11-cis-retinol

isomerohydrolase

amaurosis

leber

s-opsins

11-cis-retinoids

medicine

crbp-i

diagnostics

analysis

Reaction

retinol-[cellular-retinol-binding-protein]

retinyl-ester-[cellular-retinol-binding-protein]

Synonyms

11-cis-acyl-CoA:retinol O-acyltransferase, acyltransferase, lecithin-retinol, EC 5.2.1.3, lecithin retinol acyl transferase, lecithin retinol acyltransferase, lecithin-retinol acyltransferase, lecithin/retinol acyltransferase, lecithin: retinol acyltransferase, lecithin:retinol acyl transferase, lecithin:retinol acyltransferase, LRAT, More, retinyl ester synthase, retinyl-ester synthase

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.135 phosphatidylcholine-retinol O-acyltransferase

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Results	in table
19	Activating Compound
16	AA Sequence
7	Application
1	CAS Registry Number
26	Cloned(Commentary)
1	Crystallization (Commentary)
89	Disease/ Diagnostics
2	Expression
22	General Information
4	General Stability
28	Inhibitors
1	kcat/KM [mM/s]
39	KM Value [mM]
25	Localization
4	Metals/Ions
9	Molecular Weight [Da]
54	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
136	Organism
4	Pathway
4	PDB ID
12	pH Optimum
2	pH Range
1	pH Stability
36	Protein Variants
20	Purification (Commentary)
4	Reaction
1	Reaction Type
76	Reference
139	Source Tissue
21	Specific Activity [micromol/min/mg]
3	Storage Stability
165	Substrates and Products (Substrate)
19	Subunits
86	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Localization

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Localization on EC 2.3.1.135 - phosphatidylcholine-retinol O-acyltransferase

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endoplasmic reticulum

Homo sapiens

before initiation of retinyl ester biosynthesis, LRAT distributes throughout the endoplasmic reticulum, and Crpb1 localizes with mitochondria associated membranes, surrounded by LRAT. Upon initiating retinyl ester biosynthesis in cells, Crpb1 remains with MAM, and both Crbp1 and MAM re-localize with LRAT. LRAT formed rings around the growing lipid droplets

5783

718992

endoplasmic reticulum membrane

2 entries

lipid droplet

Homo sapiens

upon initiating retinyl ester biosynthesis in cells, Crpb1 remains with MAM, and both Crbp1 and MAM re-localize with LRAT. LRAT formed rings around the growing lipid droplets. LRAT-containing rings colocalize with the lipid-droplet surface proteins, desnutrin/adipose triglyceride lipase and perilipin 2. Colocalization with lipid droplets requires the 38 N-terminal amino acid residues of LRAT, and specifically K36 and R38. Formation of rings around the growing lipid droplets does not require functional microtubules

smooth endoplasmic reticulum

Homo sapiens

5790

658001

additional information

Homo sapiens

subcellular localization study, overview

718992