2.3.1.135: phosphatidylcholine-retinol O-acyltransferase
This is an abbreviated version!
For detailed information about phosphatidylcholine-retinol O-acyltransferase, go to the full flat file.
Word Map on EC 2.3.1.135
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2.3.1.135
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retinoids
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retinal
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all-trans-retinyl
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opsin
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11-cis-retinol
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isomerohydrolase
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amaurosis
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leber
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s-opsins
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11-cis-retinoids
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medicine
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crbp-i
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diagnostics
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analysis
- 2.3.1.135
-
retinoids
- retinal
-
all-trans-retinyl
- opsin
- 11-cis-retinol
-
isomerohydrolase
- amaurosis
-
leber
-
s-opsins
-
11-cis-retinoids
- medicine
-
crbp-i
- diagnostics
- analysis
Reaction
Synonyms
11-cis-acyl-CoA:retinol O-acyltransferase, acyltransferase, lecithin-retinol, EC 5.2.1.3, lecithin retinol acyl transferase, lecithin retinol acyltransferase, lecithin-retinol acyltransferase, lecithin/retinol acyltransferase, lecithin: retinol acyltransferase, lecithin:retinol acyl transferase, lecithin:retinol acyltransferase, LRAT, More, retinyl ester synthase, retinyl-ester synthase
ECTree
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Source Tissue
Source Tissue on EC 2.3.1.135 - phosphatidylcholine-retinol O-acyltransferase
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neoplastic and adjacent, non-neoplastic glandular breast tissue specimens from human patients, expression analysis, reduced enzyme expression, LRAT protein progressively decreases with a reduction in the degree of tumor differentiation in invasive breast carcinomas, overview
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LRAT acts together with Cyp26A1, one of the enzymes that catalyze the degradation of retinoic acid, and possibly with STRA6, the cell surface receptor for retinol-retinol-binding protein, in maintaining adequate levels of retinoids in embryonic and extraembryonic tissues
additional information
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expression in lens and lens epithelium and fibers from embryo to adulthood
the enzyme is distributed in both hepatic stellate cells and endothelial cells of normal rodent and human liver
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the enzyme is distributed in both hepatic stellate cells and endothelial cells of normal rodent and human liver
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nonparenchymal cells LRAT activity is approximately 10 fold greater than the hepatocyte LRAT activity from both vitamin A-sufficient and retinoid acid treated vitamin A-depleted rats
LRAT and cellular retinol-binding protein CRBP I are well colocalized within the liver lobules of polar bears
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GATA transcription factors are involved in the transcriptional activation of LRAT in normal human prostate epithelial cells
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adenocarcinoma, LRAT is downregulated as a result of oncogenic transformation
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transcriptional regulation of the human LRAT gene is aberrant in human prostate cancer cells
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hepatic stellate cells shift their retinyl ester synthesizing capacity from LRAT to acyl-CoA:diacylglycerol acyltransferase DGAT1 during activation
hepatic stellate cells shift their retinyl ester synthesizing capacity from LRAT to acyl-CoA:diacylglycerol acyltransferase DGAT1 during activation
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expression both in Sertoli and in spermatocytes marking initiation of spermatogenesis in prepubertal mice
expression of multiple mRNAs in a tissue-specific manner
additional information
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renal tissue expression pattern, expression is higher in renal tumor than in normal tissue
additional information
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determination of retinoid levels in liver, blood, and lung of wild-type and knockout mutant mice