2.3.1.137: carnitine O-octanoyltransferase

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For detailed information about carnitine O-octanoyltransferase, go to the full flat file.

Reaction

Synonyms

carnitine acyltransferase, Carnitine medium-chain acyltransferase, carnitine octanoyltransferase, COT, CRAT, CrOT, easily solubilized mitochondrial carnitine palmitoyltransferase, medium-chain carnitine acyltransferase, medium-chain/long-chain carnitine acyltransferase, More, overt mitochondrial carnitine palmitoyltransferase, short-chain carnitine acyltransferase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.137 carnitine O-octanoyltransferase

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Results	in table
1	Activating Compound
21	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
1	Crystallization (Commentary)
42	Disease/ Diagnostics
1	General Information
2	General Stability
35	Inhibitors
5	Ki Value [mM]
63	KM Value [mM]
84	Localization
13	Molecular Weight [Da]
131	Natural Substrates/ Products (Substrates)
563	Organism
8	PDB ID
3	pH Optimum
2	pH Range
9	Protein Variants
14	Purification (Commentary)
4	Reaction
3	Reaction Type
64	Reference
75	Source Tissue
3	Specific Activity [micromol/min/mg]
6	Storage Stability
304	Substrates and Products (Substrate)
9	Subunits
46	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

General Information

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General Information on EC 2.3.1.137 - carnitine O-octanoyltransferase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

physiological function

Homo sapiens

Q9UKG9

overexpression and knock-down of the enzyme gene in a model of hepatic cells. Increase in enzymic activity induces a decrease in medium chain fatty acid and very long chaichain fatty acid levels in the cell. These changes are accompanied by an increase in the level of mRNA encoding enzymes of the peroxisomal beta oxidation, while there is no change in mitochondrial function. A decrease in carnitine ocatanoyltransferase activity has the opposite effect. Results suggest that carnitine ocatanoyltransferase activity, by controlling the peroxisomal amount of medium chain acyls, may control the peroxisomal oxidative pathway

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