2.3.1.137: carnitine O-octanoyltransferase
This is an abbreviated version!
For detailed information about carnitine O-octanoyltransferase, go to the full flat file.
Word Map on EC 2.3.1.137
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2.3.1.137
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peroxisomal
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acyl-coas
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beta-oxidation
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malonyl-coa
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acylcarnitine
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palmitoyl-coa
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ketogenesis
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decanoyl-coa
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carnitine-dependent
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crats
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arrhythmogenesis
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2-bromopalmitate
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cpt-ii
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malonyl-coa-sensitive
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etomoxir
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palmitoylcarnitine
- 2.3.1.137
- peroxisomal
- acyl-coas
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beta-oxidation
- malonyl-coa
- acylcarnitine
- palmitoyl-coa
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ketogenesis
- decanoyl-coa
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carnitine-dependent
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crats
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arrhythmogenesis
- 2-bromopalmitate
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cpt-ii
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malonyl-coa-sensitive
- etomoxir
- palmitoylcarnitine
Reaction
Synonyms
carnitine acyltransferase, Carnitine medium-chain acyltransferase, carnitine octanoyltransferase, COT, CRAT, CrOT, easily solubilized mitochondrial carnitine palmitoyltransferase, medium-chain carnitine acyltransferase, medium-chain/long-chain carnitine acyltransferase, More, overt mitochondrial carnitine palmitoyltransferase, short-chain carnitine acyltransferase
ECTree
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Inhibitors
Inhibitors on EC 2.3.1.137 - carnitine O-octanoyltransferase
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etomoxir
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hypoglycaemia-inducing drug, double mutant H131A/H340A is insensitive to etomoxir
malonyl-CoA
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inhibits the purified enzyme, inhibition is affected by buffer, pH, substrate and presence or absence of bovine serum albumin
malonyl-CoA
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regulatory role, enzyme belongs to the group of malonyl-CoA inhibitable carnitine acyltransferases with highly conserved residues being involved in the inhibition, i.e. Thr314, Asn464, Ala478, Met593, and Cys608, amino acid sequence comparison with enzymes from other species