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2.3.1.140: rosmarinate synthase

This is an abbreviated version!
For detailed information about rosmarinate synthase, go to the full flat file.

Word Map on EC 2.3.1.140

Reaction

caffeoyl-CoA
+
(R)-3-(3,4-dihydroxyphenyl)lactate
=
CoA
+
rosmarinate

Synonyms

4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase, 4-coumaroyl-CoA:hydroxyphenyllactic acid hydroxycinnamoyltransferase, AAT1, AT1, caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid caffeoyltransferase, hydroxycinnamoyl-CoA:hydroxyphenyllactate hydroxycinnamoyltransferase, RAS, rosmarinic acid synthase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.140 rosmarinate synthase

Inhibitors

Inhibitors on EC 2.3.1.140 - rosmarinate synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3,4-Dihydroxyphenylpyruvate
Coleus scutellarioides
-
-
4-coumaroyl-CoA
-
severe substrate inhibition of 4-coumaroyl-CoA with 3-(4-hydroxyphenyl)lactate as acceptor and less with 3-(3,4-dihydroxyphenyl)lactate
4-hydroxymercuribenzoate
Coleus scutellarioides
-
complete inhibition at concentrations higher than 0.5 mM
4-hydroxyphenylpyruvate
Coleus scutellarioides
-
-
CoA
Coleus scutellarioides
-
non-competitive inhibitor
rosmarinic acid
Coleus scutellarioides
-
strong inhibitor, at concentration higher than 0.2 mM, non-competitive
S(-)-3,4-dihydroxyphenyllactate
Coleus scutellarioides
-
-
additional information
Coleus scutellarioides
-
cinnamic acids are not inhibitory
-