2.3.1.147: glycerophospholipid arachidonoyl-transferase (CoA-independent)
This is an abbreviated version!
For detailed information about glycerophospholipid arachidonoyl-transferase (CoA-independent), go to the full flat file.
Word Map on EC 2.3.1.147
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2.3.1.147
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arachidonic
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phospholipase
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platelet-activating
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paf
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transacylation
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coa-dependent
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plasmalogens
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1-acyl
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ethanolamine-containing
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alkylacylglycerophosphocholine
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arachidonylated
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arachidonoyl-coa
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arachidonate-containing
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alkylacyl-gpc
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ether-containing
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3harachidonate
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aa-containing
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ionophore-stimulated
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3hlyso-paf
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pharmacology
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medicine
- 2.3.1.147
-
arachidonic
- phospholipase
-
platelet-activating
- paf
-
transacylation
-
coa-dependent
- plasmalogens
-
1-acyl
-
ethanolamine-containing
-
alkylacylglycerophosphocholine
-
arachidonylated
- arachidonoyl-coa
-
arachidonate-containing
-
alkylacyl-gpc
-
ether-containing
-
3harachidonate
-
aa-containing
-
ionophore-stimulated
-
3hlyso-paf
- pharmacology
- medicine
Reaction
Synonyms
Acyltransferase, 1-alkylglycerophosphocholine, CoA-independent transacylase, CoA-IT, CoAIT, Coenzyme A-independent transacylase
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General Information
General Information on EC 2.3.1.147 - glycerophospholipid arachidonoyl-transferase (CoA-independent)
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metabolism
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the enzyme participates in the high affinity-low capacity pathway. Cells use this pathway to rapidly incorporate and remodel arachinonic acid through various glycerophospholipids. The predominant enzymes in this pathway include long chain fatty-acid ligase, lysophospholipid: acyl-CoA acyltransferase, and acyl-CoA independent transacylase, overview
physiological function
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arachidonic acid-phospholipid remodeling orchestrated by CoA-IT and gIVaPLA2 may function to regulate eosinophil apoptosis, overview. Regulation of arachidonic acid and phospholipid remodeling enzymes provides a mechanism for regulating not only eicosanoid production, but also the increased life-span of eosinophils in allergic asthma, overview
physiological function
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CoA-independent transacylase is a major regulator of arachidonic acid metabolism in human monocytes. Arachidonic acid incorporation into phospholipids is similar in both monocytes and U-937 cells, but a marked difference in the rate of remodeling is appreciated. U-937 cells remodel arachidonic acid at a much faster rate than human monocytes. This difference is not related to the differentiation state of the U-937 cells, but rather to the low levels of esterified arachidonate found in U-937 cells compared to human monocytes. Incubating the U-937 cells in arachidonic acid-rich media increases the cellular content of this fatty acid and leads to a substantial decrease of the rate of phospholipid arachidonic acid remodeling, which is due to reduced CoA-independent transacylase activity