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2.3.1.15: glycerol-3-phosphate 1-O-acyltransferase

This is an abbreviated version!
For detailed information about glycerol-3-phosphate 1-O-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.15

Reaction

an acyl-CoA
+
sn-glycerol 3-phosphate
=
CoA
+
a 1-acyl-sn-glycerol 3-phosphate

Synonyms

1-acyl-sn-glycerol-3-phosphate acyltransferase, 3-glycerophosphate acyltransferase, ACP:sn-glycerol-3-phosphate acyltransferase, acyl-CoA:glycerol-3-phosphate acyltransferase 1, acyl-CoA:sn-glycerol-3-phosphate O-acyltransferase, acyl-[acyl carrier protein]:sn-1-glycerol-3-phosphate acyltransferase, acyltransferase, glycerol phosphate, Ad-GPAT1, AGPAT, AGPAT10, AGPAT6, AGPAT8, AGPAT9, alpha-glycerophosphate acyltransferase, AT1G02390, AT1G06520, AT3G11430, AT4G00400, AT4G01950, AT5G06090, AT5G60620, AtGPAT1, AtGPAT2, AtGPAT3, AtGPAT5, AtGPAT7, AtGPAT8, AtGPAT9, cancer-testicular antigen, chloroplast glycerol-3-phosphate acyltransferase, CrGAPTcl, ER-associated GPAT, G3P acyltransferase, GAT, Gat1, GAT1p, GAT2p, glycerol 3-phosphate acyltransferase, glycerol phosphate acyltransferase, glycerol phosphate transacylase, glycerol-3-P acyltransferase 1, glycerol-3-phosphate acyltransferase, glycerol-3-phosphate acyltransferase 1, glycerol-3-phosphate acyltransferase 2, glycerol-3-phosphate acyltransferase 3, glycerol-3-phosphate acyltransferase 4, glycerol-3-phosphate acyltransferase 9, glycerol-3-phosphate acyltransferase-1, glycerol-3-phosphate acyltransferase-like protein 1, glycerol-3-phosphate O-acyltransferase, glycerol-3-phosphate-1 acyltransferase, glycerol-sn-3-phosphate acyltransferase 1, glycerophosphate acyltransferase, glycerophosphate transacylase, GPAM, GPAT, GPAT-1, GPAT-4, GPAT-9, GPAT1, GPAT2, GPAT3, GPAT3/AGPAT10, GPAT4, GPAT5, GPAT6, GPAT7, GPAT8, GPAT9, gpt1, Gpt2, LeGPAT, LiGPAT, LPAAT-theta, LPAAT-zeta, mGPAT, microsomal GPAT3, microsomal GPAT3/AGPAT10, microsomal GPAT4, mitochondrial glycerol-3-phosphate acyltransferase, mitochondrial GPAT1, mitochondrial GPAT2, More, MS33, mtGPAT, mtGPAT1, mtGPAT2, OsGPAT3, PHATRDRAFT_42446, PHYPADRAFT_137573, PLAT2, PlsB, PlsB1, Ppa GPAT9, PpGPAT9, PtGPAT, Rv1551, Rv1551 acyltransferase, SA1, Sn-glycerol 3-phosphate acyltransferase, sn-glycerol-3-phosphate acyltransferase, SsGPAT, TbGAT, water-soluble plastidial glycerol-3-phosphate acyltransferase, xGPAT1, xGPAT1-v1, xGPAT1-v2

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.15 glycerol-3-phosphate 1-O-acyltransferase

Crystallization

Crystallization on EC 2.3.1.15 - glycerol-3-phosphate 1-O-acyltransferase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
docking experiments with the soluble squash chloroplast enzyme crystal structure, PDB code 1k30, and inhibitors (1S,2R,3R)-2-hydroxy-3-[(octylsulfonyl)amino]cyclopentanecarboxylic acid, (+-)-2-hydroxy-3-(octylsulfonamido)-cyclohexanecarboxylic acid, (1S,2S,3S)-2-hydroxy-3-[(octylsulfonyl)amino]cyclopentanecarboxylic acid, and (+-)-2-(2-hydroxy-3-(octylsulfonamido)-cyclopentyl)acetic acid. Cyclopentyl and cyclohexyl scaffolds of the inhibitors may be occluded from the enzyme active site by two protein loops that sterically guard the phosphate binding region
hanging-drop vapour diffusion, poly(ethylene glycol) 4000 as precipitant, 1.9 A resolution
-
purified recombinant native and selenomethionine-labeled wild-type and chimeric enzymes, 14 mg/ml protein in 20 mM sodium phosphate, pH 8.0, 4°C, hanging drop vapour diffusion method, crystallization solution contains 4-25% PEG 4000, 0.1 M ammonium acetate,10% v/v 2-propanolin 100 mM citrate, pH 5.6, X-ray diffraction structure determination and analysis at 1.55 A resolution
-
recombinant chimeric enzyme, 14 mg/ml protein in 20 mM sodium phosphate, pH 8.0, 4°C, hanging drop vapour diffusion method, crystallization solution contains 4-25% PEG 4000, 0.1 M ammonium acetate,10% v/v 2-propanolin 100 mM citrate, pH 5.6, X-ray diffraction structure determination and analysis at 1.55 A resolution
-