Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.3.1.159: acridone synthase

This is an abbreviated version!
For detailed information about acridone synthase, go to the full flat file.

Word Map on EC 2.3.1.159

Reaction

3 malonyl-CoA +

N-methylanthraniloyl-CoA
= 4 CoA +
1,3-dihydroxy-N-methylacridone
 + 3 CO2 +
H2O

Synonyms

acridone synthase, ACS, ACS2, PKS1, synthatase, acridone (9Cl)

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.159 acridone synthase

Substrates Products

Substrates Products on EC 2.3.1.159 - acridone synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3 malonyl-CoA + 4-coumaroyl-CoA
4 CoA + naringenin chalcone + 3 CO2
show the reaction diagram
-
enzyme accepts 4-coumaroyl-CoA as a starter substrate to yield naringenin chalcone, along with triketide and tetraketide lactone derailment by-products
-
?
3 malonyl-CoA + benzoyl-CoA
4 CoA + benzophenone + 3 CO2
show the reaction diagram
-
-
-
?
3 malonyl-CoA + hexanoyl-CoA
4 CoA + phloroglucinol + 3 CO2
show the reaction diagram
-
-
-
?
3 malonyl-CoA + N-methylanthraniloyl-CoA
4 CoA + 1,3-dihydroxy-N-methylacridone + N-methylanthraniloyltriacetic acid lactone + 4-hydroxy-N-methylquinolone + 3 CO2
show the reaction diagram
-
enzyme accepts N-methylanthraniloyl-CoA as the starter substrate to produce the tetraketide 1,3-dihydroxy-N-methylacridone after sequential condensations with three molecules of malonyl-CoA, along with 4-hydroxy-N-methylquinolone and N-methylanthraniloyltriacetic acid lactone. The catalytic efficiency for the formation of the acridone is 2.8fold higher than that of the quinolone
-
?
4-coumaroyl-CoA + 3 malonyl-CoA
naringenin chalcone + 4 CoA + 3 CO2
show the reaction diagram
-
small amounts of bisnoryangonin and 4-coumaroyltriacetic acid lactone are formed as byproducts
-
?
4-methoxycinnamoyl-CoA + 3 malonyl-CoA
4-methoxy-2',4',6'-trihydroxychalcone + CoA + CO2
show the reaction diagram
-
-
-
-
?
4-methoxycinnamoyl-CoA + malonyl-CoA
? + CoA + CO2
show the reaction diagram
-
-
-
?
acetyl-CoA + malonyl-CoA
? + CoA + CO2
show the reaction diagram
-
-
-
?
benzoyl-CoA + malonyl-CoA
2,3',4,6-tetrahydroxybenzophenone + CoA + CO2
show the reaction diagram
-
-
-
?
hexanoyl-CoA + malonyl-CoA
? + CoA + CO2
show the reaction diagram
-
-
-
?
malonyl-CoA + 4-coumaroyl-CoA
CoA + naringenin chalcone
show the reaction diagram
malonyl-CoA + N-methylanthraniloyl-CoA
CoA + 1,3-dihydroxy-N-methylacridone + CO2
show the reaction diagram
N-methylanthraniloyl-CoA + 3 malonyl-CoA
1,3-dihydroxy-N-methylacridone + 4 CoA + 3 CO2
show the reaction diagram
-
-
-
?
N-methylanthraniloyl-CoA + 3 malonyl-CoA
1,3-dihydroxy-N-methylacridone + CoA + CO2
show the reaction diagram
phenylacetyl-CoA + malonyl-CoA
2,4,6-trihydroxyphenylbenzylketone + CoA + CO2
show the reaction diagram
-
-
-
?
additional information
?
-