2.3.1.16: acetyl-CoA C-acyltransferase

This is an abbreviated version!
For detailed information about acetyl-CoA C-acyltransferase, go to the full flat file.

Reaction

Synonyms

2-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-oxoacyl-CoA thiolase, 3-KAT, 3-ketoacyl CoA thiolase, 3-ketoacyl coenzyme A thiolase, 3-ketoacyl coenzyme-A thiolase, 3-ketoacyl thiolase, 3-ketoacyl-CoA thiolase, 3-ketothiolase, 3-oxoacyl-CoA thiolase, 3-oxoacyl-coenzyme A thiolase, 3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase, 6-oxoacyl-CoA thiolase, ACAA2, acetoacetyl-CoA beta-ketothiolase, acetyl-CoA acyltransferase, acyl-CoA-thiolase, acyltransferase, acetyl coenzyme A, beta-ketoacyl coenzyme A thiolase, beta-ketoacyl-CoA thiolase, beta-ketoadipyl coenzyme A thiolase, beta-ketoadipyl-CoA thiolase, beta-ketothiolase, BktB, ELo1, Elovl-5, Elovl-6, ELOVL5, Elovl6, enoyl-coenzyme A (CoA) hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase trifunctional protein, FadA, fatty acid elongase 5, KAT, KAT-1, KAT2, ketoacyl-CoA acyltransferase, ketoacyl-coenzyme A thiolase, long-chain 3-oxoacyl-CoA thiolase, mitochondrial 3-ketoacyl-CoA thiolase, oxoacyl-coenzyme A thiolase, PaaJ, pro-3-ketoacyl-CoA thiolase, PUFA elongase, SCP2/3-oxoacyl-CoA thiolase, SCPx, sterol carrier protein 2/3-oxoacyl-CoA thiolase, TFE-beta subunit, Thb, thiloase B, thiolase A, thiolase I, thiolase II, thiolase III

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.16 acetyl-CoA C-acyltransferase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
3	Activating Compound
28519	AA Sequence
5	Application
1	CAS Registry Number
16	Cloned(Commentary)
2	Cofactor
8	Crystallization (Commentary)
858	Disease/ Diagnostics
2	Expression
14	General Information
3	General Stability
18	IC50 Value
47	Inhibitors
4	Ki Value [mM]
43	KM Value [mM]
41	Localization
2	Metals/Ions
38	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
170	Organism
70	Pathway
113	PDB ID
11	pH Optimum
3	pH Range
3	pH Stability
1	pI Value
3	Posttranslational Modification
9	Protein Variants
29	Purification (Commentary)
25	Reaction
4	Reaction Type
80	Reference
1	Renatured (Commentary)
70	Source Tissue
24	Specific Activity [micromol/min/mg]
8	Storage Stability
172	Substrates and Products (Substrate)
30	Subunits
70	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
8	Temperature Stability [°C]
3	Turnover Number [1/s]

Natural Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Natural Substrates Products on EC 2.3.1.16 - acetyl-CoA C-acyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Natural Substrate Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2 acetyl-CoA

CoA + acetoacetyl-CoA

Homo sapiens

P42765

reaction of EC 2.3.1.9

735368

-

-

r

5-methyl-3-oxo-4-hexenoyl-CoA + CoA

3-methylcrotonyl-CoA + acetyl-CoA

Pseudomonas citronellolis

-

-

717129

-

-

?

7-methyl-3-oxo-6-octenoyl-CoA + CoA

5-methylhex-4-enoyl-CoA + acetyl-CoA

Pseudomonas citronellolis

-

-

717129

-

-

?

acetyl-CoA + H2O

acetate + CoA

3 entries

acyl-CoA + acetyl-CoA

CoA + 3-oxoacyl-CoA

2 entries

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

18 entries

CoA + acetoacetyl-CoA

2 acetyl-CoA

Homo sapiens

P42765

-

735368

-

-

r

additional information

?

-

10 entries

acetyl-CoA + H2O

acetate + CoA

Rattus norvegicus

-

3-ketoacyl-CoA thiolase activity

664215

-

-

?

acetyl-CoA + H2O

acetate + CoA

Thermus thermophilus

-

-

675941

-

-

r

acetyl-CoA + H2O

acetate + CoA

Thermus thermophilus HB8 / ATCC 27634 / DSM 579

-

-

675941

-

-

r

acyl-CoA + acetyl-CoA

CoA + 3-oxoacyl-CoA

Homo sapiens

-

-

686251

-

-

?

acyl-CoA + acetyl-CoA

CoA + 3-oxoacyl-CoA

Homo sapiens

P42765

-

735368

-

-

?

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

Arabidopsis thaliana

Q56WD9

metabolism in the peroxisome influences metabolism in the lipid body

486438

-

-

?

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

Arabidopsis thaliana

Q56WD9

enzyme catalyses step of fatty acid beta-oxidation

486438

-

-

?

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

Brassica napus

-

enzyme catalyses the last step in the beta-oxidation cycle

288682

-

-

?

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

Caulobacter vibrioides

-

-

487691

-

-

?

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

Escherichia coli

-

-

2962, 286604, 486426

-

-

?

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

Escherichia coli B / ATCC 11303

-

-

2962

-

-

?

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

Homo sapiens

-

enzyme catalyses step of fatty acid beta-oxidation

486411

-

-

?

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

Pseudomonas fragi

-

-

2213

-

-

?

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

Rattus norvegicus

Q64428

-

288681

-

-

?

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

Rattus norvegicus

-

enzyme catalyses the last step in the beta-oxidation cycle

486437

-

-

?

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

Rattus norvegicus

-

enzyme plays important role in peroxisomal beta-oxidation, in addition the enzyme may facilitate the intraperoxysomal movement of sterols and certain other lipids

288674

-

-

?

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

Rattus norvegicus Wistar

-

-

288681

-

-

?

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

Saccharomyces cerevisiae

-

-

286604

-

-

?

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

Saccharomyces cerevisiae

-

enzyme catalyses the last step in the beta-oxidation cycle

486431

-

-

?

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

Saccharomyces cerevisiae

P27796

enzyme catalyses the last step in the beta-oxidation cycle

486433

-

-

?

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

Saccharomyces cerevisiae

-

enzyme catalyses step of fatty acid beta-oxidation

288675

-

-

?

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

Sus scrofa

-

-

486412

-

-

?

CoA + 3-oxoacyl-CoA

acyl-CoA + acetyl-CoA

Sus scrofa

-

enzyme catalyses the last step in the beta-oxidation cycle

486404

-

-

r

additional information

?

-

Arabidopsis thaliana

Q56WD9

the peroxisomal isozyme is a biodegradative type 1 thiolase showing potential for redox control of peroxisomal fatty acid beta-oxidation, KAT activity in peroxisomes is influenced by a disulfide/dithiol change linking fatty acid beta-oxidation, overview

675383

-

-

?

additional information

?

-

Arabidopsis thaliana

-

the peroxisomal isozyme is a biodegradative type 1 thiolase showing potential for redox control of peroxisomal fatty acid beta-oxidation, KAT activity in peroxisomes is influenced by a disulfide/dithiol change linking fatty acid beta-oxidation, overview

675383

-

-

?

additional information

?

-

Homo sapiens

P42765

the enzyme catalyzes the thiolytic cleavage of medium-chain to long-chain 3-oxoacyl-CoAs to acetyl-CoA and a fatty acyl-CoA shortened by two C atom, the reaction involves residues C382, C92, and H352, overview. The enzyme can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA, EC 2.3.1.9

735368

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme catalyzes the thiolytic cleavage of medium-chain to long-chain 3-oxoacyl-CoAs to acetyl-CoA and a fatty acyl-CoA shortened by two C atom, the reaction involves residues C382, C92, and H352, overview. The enzyme can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA, EC 2.3.1.9

735368

-

-

?

additional information

?

-

Rattus norvegicus

-

key enzyme involved in fatty acid oxidation

660434

-

-

?

additional information

?

-

Rattus norvegicus

-

the enzyme is involved in fatty acid beta-oxidation

664215

-

-

?

additional information

?

-

Spodoptera littoralis

Q66Q58

sterol carrier protein 2/3-oxoacyl-CoA thiolase is involved in trafficing of sterols and oxidation of branched-chain fatty acids

657848

-

-

?

additional information

?

-

Spodoptera littoralis

-

sterol carrier protein 2/3-oxoacyl-CoA thiolase is involved in trafficing of sterols and oxidation of branched-chain fatty acids

657848

-

-

?

additional information

?

-

Thermus thermophilus

-

first enzyme of the most common biosynthetic pathway for polyhydroxyalkanoates, overview

675941

-

-

?

additional information

?

-

Thermus thermophilus HB8 / ATCC 27634 / DSM 579

-

first enzyme of the most common biosynthetic pathway for polyhydroxyalkanoates, overview

675941

-

-

?