2.3.1.161: lovastatin nonaketide synthase
This is an abbreviated version!
For detailed information about lovastatin nonaketide synthase, go to the full flat file.
Word Map on EC 2.3.1.161
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2.3.1.161
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polyketide
-
iterative
-
synthases
-
terreus
-
medicine
-
enoyl
-
megasynthase
-
cholesterol-lowering
-
s-adenosylmethionine
-
diketide
-
2-methylbutyrate
-
pyrones
-
transesterase
- 2.3.1.161
- polyketide
-
iterative
- synthases
- terreus
- medicine
-
enoyl
-
megasynthase
-
cholesterol-lowering
- s-adenosylmethionine
-
diketide
- 2-methylbutyrate
- pyrones
-
transesterase
Reaction
9 malonyl-CoA
+
11 NADPH
+
10 H+
+
Synonyms
LNKS, lovastatin nonaketide synthase, LovB, synthase, lovastatin nonaketide
ECTree
2.3.1.161 lovastatin nonaketide synthaseAdvanced search results
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Engineering on EC 2.3.1.161 - lovastatin nonaketide synthase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
S656A
additional information
S656A
inactivation of malonyl-coenzyme A:acyl carrier protein acyltransferase domain in ketosynthase-malonyl-coenzyme A:acyl carrier protein acyltransferase for assay of ketosynthase activity. Ketosynthase displays no activity towards acetyl groups but recognizes malonyl groups in the absence of cerulenin
additional information
-
expression of minimal polyketide synthase domains of subunit LovB as standalone proteins. The didomain proteins ketosynthase-malonyl-coenzyme A:acyl carrier protein acyltransferase KS-MAT can transfer the acyl group to both the cognate LovB acyl carrier protein and heterologous acyl carrier proteins from bacterial type I and type II polyketide synthases. It transfers malonyl and acetyl groups with kcat/Km values of 0.62 per min and 0.032 per min, resp
additional information
expression of minimal polyketide synthase domains of subunit LovB as standalone proteins. The didomain proteins ketosynthase-malonyl-coenzyme A:acyl carrier protein acyltransferase KS-MAT can transfer the acyl group to both the cognate LovB acyl carrier protein and heterologous acyl carrier proteins from bacterial type I and type II polyketide synthases. It transfers malonyl and acetyl groups with kcat/Km values of 0.62 per min and 0.032 per min, resp
