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2.3.1.165: 6-methylsalicylic-acid synthase

This is an abbreviated version!
For detailed information about 6-methylsalicylic-acid synthase, go to the full flat file.

Word Map on EC 2.3.1.165

Reaction

acetyl-CoA
+ 3 malonyl-CoA +
NADPH
 +
H+
=
6-Methylsalicylate
 + 4 CoA + 3 CO2 +
NADP+
 +
H2O

Synonyms

6-methylsalicylic acid synthase, 6-methylsalicylic acid synthetase, 6-methylsalicylic-acid synthase, 6-MSA, 6-MSA synthase, 6-MSAS, aomsas, ASPAC_1904397, ASPNIDRAFT_44965, ATX, ChlB1, iPKS, iterative type I polyketide synthase, methylsalicylic acid synthase, MSAS, Pks2, PKS48, YanA

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.165 6-methylsalicylic-acid synthase

Cloned

Cloned on EC 2.3.1.165 - 6-methylsalicylic-acid synthase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Aspergillus nidulans
-
expressed in Saccharomyces cerevisiae
expression in Aspergillus nidulans
expression in Escherichia coli
expression in Escherichia coli and Saccharomyces cerevisiae can be used for 4-hydroxy-6-methyl-2-pyrone production
-
for expression in Saccharomyces cerevisiae
functional expression in Aspergillus nidulans
functional expression of ATX in Escherichia coli strain BL21(DE3)-CodonPlus RIPL, expression of N-terminally His6-tagged ATX and its thioester hydrolase domain, and the truncated mutant enzyme form, THID
-
into the PCR2.1 Topo cloning kit
paart of Chl gene cluster of chlorothricin producer Streptomyces antibioticus
-