2.3.1.165: 6-methylsalicylic-acid synthase
This is an abbreviated version!
For detailed information about 6-methylsalicylic-acid synthase, go to the full flat file.
Word Map on EC 2.3.1.165
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2.3.1.165
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metropolitan
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myositis-specific
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autoantibodies
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myositis
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dermatomyositis
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services
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myopathy
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census
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savings
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subscale
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polymyositis
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anti-srp
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anti-mi-2
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medicare
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anti-jo-1
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patulum
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myositis-associated
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anti-mda5
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anti-tif1
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mda5
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microtubule-stabilizing
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payment
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amyopathic
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anti-signal
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poverty
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fusimotor
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cronbach
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residue-residue
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ketoreductase
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financing
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epothilone
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anti-synthetase
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alpha-chloralose
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beneficiaries
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anti-hmgcr
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food industry
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biotechnology
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synthesis
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medicine
- 2.3.1.165
-
metropolitan
-
myositis-specific
- autoantibodies
- myositis
- dermatomyositis
-
services
- myopathy
-
census
-
savings
-
subscale
- polymyositis
-
anti-srp
-
anti-mi-2
-
medicare
-
anti-jo-1
- patulum
-
myositis-associated
-
anti-mda5
-
anti-tif1
- mda5
-
microtubule-stabilizing
-
payment
-
amyopathic
-
anti-signal
-
poverty
-
fusimotor
-
cronbach
-
residue-residue
- ketoreductase
-
financing
-
epothilone
-
anti-synthetase
-
alpha-chloralose
-
beneficiaries
-
anti-hmgcr
- food industry
- biotechnology
- synthesis
- medicine
Reaction
Synonyms
6-methylsalicylic acid synthase, 6-methylsalicylic acid synthetase, 6-methylsalicylic-acid synthase, 6-MSA, 6-MSA synthase, 6-MSAS, aomsas, ASPAC_1904397, ASPNIDRAFT_44965, ATX, ChlB1, iPKS, iterative type I polyketide synthase, methylsalicylic acid synthase, MSAS, Pks2, PKS48, YanA
ECTree
2.3.1.165 6-methylsalicylic-acid synthaseAdvanced search results
results (
results (Engineering
Engineering on EC 2.3.1.165 - 6-methylsalicylic-acid synthase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
H972A
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site-directed mutagenesis, the reaction intermediate is bound to the thioester hydrolase domain of ATX formed in the presence of NADPH, and is released as 6-methylsalicylic acid by both the intact ATX and by truncated THID mutant in trans
additional information
additional information
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N-terminal deletion mutant ATXN1 lacking 44 amino acids, catalytically active. N-terminal deletion mutant ATXN2 lacking 81 amino acids including part of the ketosynthase domain, loss of catalytic activity. Both ATXC1 lacking 9 carboxyterminal amino acids and ATXC2 lacking 21 carboxyterminal amino acids including part of the conserved acyl carrier protein domain are inactive. Coexpression of inactive mutants ATXN2 with ATXC1 or ATXC2 results in restauration of activity. Identification of an interdomain region required for the formation of the active reaction center
additional information
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deletion of one of the 6-methylsalicylic acid synthase domains ketosynthase, acyltransferase, dehydratase, ketoreductase, or acyl carrier protein results in a lost of catalytic activity
additional information
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construction of the THID mutant protein, a His-tagged 61 kDA 541-amino acid region containing thioester hydrolase domain and its downstream, THID shows catalytic activity to hydrolyze a model substrate 6-methylsalicylic acid-N-acetylcysteamine. The complementation of thioester domain-deficient mutant THm by THID protein in the recombinant Escherichia coli expression system
additional information
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aomsas disruption mutants are not able to produce 6-methylsalicylic acid, isoasperlactone and asperlactone
additional information
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Saccharomyces cerevisiae strain IBT100083 with a ACC1-TEF1 promoter produces high levels of acetyl-CoA carboxylase (ACC1) which catalyzes the conversion of acetyl-CoA to malonyl-CoA. Hence, more substrate for 6-methylsalicylic acid synthase is available resulting in a higher 6-MSA production.
