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2.3.1.165: 6-methylsalicylic-acid synthase

This is an abbreviated version!
For detailed information about 6-methylsalicylic-acid synthase, go to the full flat file.

Word Map on EC 2.3.1.165

Reaction

acetyl-CoA
+ 3 malonyl-CoA +
NADPH
+
H+
=
6-Methylsalicylate
+ 4 CoA + 3 CO2 +
NADP+
+
H2O

Synonyms

6-methylsalicylic acid synthase, 6-methylsalicylic acid synthetase, 6-methylsalicylic-acid synthase, 6-MSA, 6-MSA synthase, 6-MSAS, aomsas, ASPAC_1904397, ASPNIDRAFT_44965, ATX, ChlB1, iPKS, iterative type I polyketide synthase, methylsalicylic acid synthase, MSAS, Pks2, PKS48, YanA

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.165 6-methylsalicylic-acid synthase

Inhibitors

Inhibitors on EC 2.3.1.165 - 6-methylsalicylic-acid synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2S,3R)-2,3-epoxy-4-oxo-7,10-dodecadienoylamide
1,3-dibromo-propane-2-one
5,5'-dithiobis(2-nitrobenzoic acid)
-
0.01 mM, rapid inactivation, inactivation half-life: approx. 15 s, both acetyl-CoA and malonyl-CoA protect
iodoacetamide
NAD+
-
0.3 mM, 21% inhibition in crude extracts
NADH
-
0.3 mM, 26% inhibition in crude extracts
NADP+
-
0.3 mM, 21% inhibition in crude extracts
nicotinamide hypoxanthine dinucleotide phosphate
-
reduced form, 0.3 mM, 32% inhibition in crude extracts, oxidized form, 0.3 mM, 24% inhibition in crude extracts
additional information
-
no inhibition by phenylmethylsulfonyl fluoride, a serine protease-type thioesterase inhibitor at 1 mM
-