2.3.1.165: 6-methylsalicylic-acid synthase
This is an abbreviated version!
For detailed information about 6-methylsalicylic-acid synthase, go to the full flat file.
Word Map on EC 2.3.1.165
-
2.3.1.165
-
metropolitan
-
myositis-specific
-
autoantibodies
-
myositis
-
dermatomyositis
-
services
-
myopathy
-
census
-
savings
-
subscale
-
polymyositis
-
anti-srp
-
anti-mi-2
-
medicare
-
anti-jo-1
-
patulum
-
myositis-associated
-
anti-mda5
-
anti-tif1
-
mda5
-
microtubule-stabilizing
-
payment
-
amyopathic
-
anti-signal
-
poverty
-
fusimotor
-
cronbach
-
residue-residue
-
ketoreductase
-
financing
-
epothilone
-
anti-synthetase
-
alpha-chloralose
-
beneficiaries
-
anti-hmgcr
-
food industry
-
biotechnology
-
synthesis
-
medicine
- 2.3.1.165
-
metropolitan
-
myositis-specific
- autoantibodies
- myositis
- dermatomyositis
-
services
- myopathy
-
census
-
savings
-
subscale
- polymyositis
-
anti-srp
-
anti-mi-2
-
medicare
-
anti-jo-1
- patulum
-
myositis-associated
-
anti-mda5
-
anti-tif1
- mda5
-
microtubule-stabilizing
-
payment
-
amyopathic
-
anti-signal
-
poverty
-
fusimotor
-
cronbach
-
residue-residue
- ketoreductase
-
financing
-
epothilone
-
anti-synthetase
-
alpha-chloralose
-
beneficiaries
-
anti-hmgcr
- food industry
- biotechnology
- synthesis
- medicine
Reaction
+ 3 malonyl-CoA + + = + 4 CoA + 3 CO2 + +
Synonyms
6-methylsalicylic acid synthase, 6-methylsalicylic acid synthetase, 6-methylsalicylic-acid synthase, 6-MSA, 6-MSA synthase, 6-MSAS, aomsas, ASPAC_1904397, ASPNIDRAFT_44965, ATX, ChlB1, iPKS, iterative type I polyketide synthase, methylsalicylic acid synthase, MSAS, Pks2, PKS48, YanA
ECTree
Advanced search results
Inhibitors
Inhibitors on EC 2.3.1.165 - 6-methylsalicylic-acid synthase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
5,5'-dithiobis(2-nitrobenzoic acid)
-
0.01 mM, rapid inactivation, inactivation half-life: approx. 15 s, both acetyl-CoA and malonyl-CoA protect
nicotinamide hypoxanthine dinucleotide phosphate
-
reduced form, 0.3 mM, 32% inhibition in crude extracts, oxidized form, 0.3 mM, 24% inhibition in crude extracts
additional information
-
no inhibition by phenylmethylsulfonyl fluoride, a serine protease-type thioesterase inhibitor at 1 mM
-
-
mycotoxin produced by Cephalosporium caerulens, trivial name cerulenin, 0.2 mM, complete inactivation after approx. 30 min, second-order rate constant for the reaction with 6-methylsalicylic acid synthase: 13.8 M/s, acetyl-CoA protects, site of modification: Cys204
(2S,3R)-2,3-epoxy-4-oxo-7,10-dodecadienoylamide
-
0.0014 mM, complete inactivation after 40 min, acetyl-CoA protects
-
0.02 mM, complete inactivation after 40 min, acetyl-CoA protects
1,3-dibromo-propane-2-one
-
very rapid inactivation, inactivation half-life: 7 s
-
0.5 mM, complete inactivation of synthetase activity after 15 min at 0°C, enzyme is then able to decarboxlate malonyl-CoA
iodoacetamide
-
100 mM, complete inactivation after 45 min, site of modification: Cys204
iodoacetamide
-
100fold molar excess, complete inactivation after 30 min