2.3.1.165: 6-methylsalicylic-acid synthase
This is an abbreviated version!
For detailed information about 6-methylsalicylic-acid synthase, go to the full flat file.
Word Map on EC 2.3.1.165
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2.3.1.165
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metropolitan
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myositis-specific
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autoantibodies
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myositis
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dermatomyositis
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services
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myopathy
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census
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savings
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subscale
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polymyositis
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anti-srp
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anti-mi-2
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medicare
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anti-jo-1
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patulum
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myositis-associated
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anti-mda5
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anti-tif1
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mda5
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microtubule-stabilizing
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payment
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amyopathic
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anti-signal
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poverty
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fusimotor
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cronbach
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residue-residue
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ketoreductase
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financing
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epothilone
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anti-synthetase
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alpha-chloralose
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beneficiaries
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anti-hmgcr
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food industry
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biotechnology
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synthesis
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medicine
- 2.3.1.165
-
metropolitan
-
myositis-specific
- autoantibodies
- myositis
- dermatomyositis
-
services
- myopathy
-
census
-
savings
-
subscale
- polymyositis
-
anti-srp
-
anti-mi-2
-
medicare
-
anti-jo-1
- patulum
-
myositis-associated
-
anti-mda5
-
anti-tif1
- mda5
-
microtubule-stabilizing
-
payment
-
amyopathic
-
anti-signal
-
poverty
-
fusimotor
-
cronbach
-
residue-residue
- ketoreductase
-
financing
-
epothilone
-
anti-synthetase
-
alpha-chloralose
-
beneficiaries
-
anti-hmgcr
- food industry
- biotechnology
- synthesis
- medicine
Reaction
+ 3 malonyl-CoA + + = + 4 CoA + 3 CO2 + +
Synonyms
6-methylsalicylic acid synthase, 6-methylsalicylic acid synthetase, 6-methylsalicylic-acid synthase, 6-MSA, 6-MSA synthase, 6-MSAS, aomsas, ASPAC_1904397, ASPNIDRAFT_44965, ATX, ChlB1, iPKS, iterative type I polyketide synthase, methylsalicylic acid synthase, MSAS, Pks2, PKS48, YanA
ECTree
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Reaction
Reaction on EC 2.3.1.165 - 6-methylsalicylic-acid synthase
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acetyl-CoA + 3 malonyl-CoA + NADPH + H+ = 6-methylsalicylate + 4 CoA + 3 CO2 + NADP+ + H2O
a multienzyme complex with a 4'-phosphopantetheine prosthetic group on the acyl carrier protein, it has a similar sequence to vertebrate type I fatty acid synthase, acetoacetyl-CoA can also act as a starter molecule
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acetyl-CoA + 3 malonyl-CoA + NADPH + H+ = 6-methylsalicylate + 4 CoA + 3 CO2 + NADP+ + H2O
steric course of the reaction, mechanism
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acetyl-CoA + 3 malonyl-CoA + NADPH + H+ = 6-methylsalicylate + 4 CoA + 3 CO2 + NADP+ + H2O
6-methylsalicylate synthesis proceeds without catalytic dehydration of the beta-hydroxy triketide intermediate by DH domain which is therefore not required for tetraketide formation. The subsequent aldol cyclization and aromatization of the tetraketide intermediate then form 6-methylsalicylate covalently bound to the ACP phosphopantetheine arm as the thioester. 6-methylsalicylate is released hydrolytically from ATX by the action of the domain hitherto called DH domain, i.e. the thioester hydrolase catalytic domain
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acetyl-CoA + 3 malonyl-CoA + NADPH + H+ = 6-methylsalicylate + 4 CoA + 3 CO2 + NADP+ + H2O
a multienzyme complex with a 4'-phosphopantetheine prosthetic group on the acyl carrier protein, it has a similar sequence to vertebrate type I fatty acid synthase, acetoacetyl-CoA can also act as a starter molecule
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