2.3.1.168: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase

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For detailed information about dihydrolipoyllysine-residue (2-methylpropanoyl)transferase, go to the full flat file.

Reaction

Synonyms

Bkd, BKDH, DBT, dihydrolipoamide branched chain transacylase, dihydrolipoyl transacetylase, DLD, E2, E2p, More

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.168 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase

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Results	in table
174	AA Sequence
3	Application
13	Cloned(Commentary)
4	General Information
6	Inhibitors
6	KM Value [mM]
7	Localization
7	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
36	Organism
5	Pathway
41	PDB ID
1	pH Optimum
3	Protein Variants
8	Purification (Commentary)
4	Reaction
1	Reaction Type
34	Reference
4	Renatured (Commentary)
13	Source Tissue
5	Specific Activity [micromol/min/mg]
49	Substrates and Products (Substrate)
24	Subunits
34	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.3.1.168 - dihydrolipoyllysine-residue (2-methylpropanoyl)transferase

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SYSTEMATIC NAME

IUBMB Comments

2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-(2-methylpropanoyl)transferase

A multimer (24-mer) of this enzyme forms the core of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex, and binds tightly both EC 1.2.4.4, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively 2-methylpropanoylated by EC 1.2.4.4, and the only observed direction catalysed by EC 2.3.1.168 is that where this 2-methylpropanoyl is passed to coenzyme A. In addition to the 2-methylpropanoyl group, formed when EC 1.2.4.4 acts on the oxoacid that corresponds with valine, this enzyme also transfers the 3-methylbutanoyl and S-2-methylbutanoyl groups, donated to it when EC 1.2.4.4 acts on the oxo acids corresponding with leucine and isoleucine.