2.3.1.169: CO-methylating acetyl-CoA synthase

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For detailed information about CO-methylating acetyl-CoA synthase, go to the full flat file.

Reaction

Synonyms

ACDS multienzyme complex, acetyl-CoA decarbonylase/synthase multienzyme complex, acetyl-CoA decarboxylase/synthase, Acetyl-CoA synthase, Acetyl-coenzyme A synthase, acetyl-coenzyme A synthase/carbon monoxide dehydrogenase, ACS/CODH, ACSCh, Carbon monoxide dehydrogenase, carbon monoxide dehydrogenase-corrinoid enzyme complex, carbon monoxide dehydrogenase/acetyl coenzyme A synthase, carbon monoxide dehydrogenase/acetyl-CoA synthase, carbon monoxide dehydrogenase/acetyl-coenzyme A synthase, CDH1, Cdh2, CO dehydrogenase, CO dehydrogenase enzyme complex, CO dehydrogenase/acetyl CoA synthase, CO dehydrogenase/acetyl coenzyme A synthase, CO dehydrogenase/acetyl-CoA synthase, CODH, CODH/ACS, CODH/ASC, KSU1_D0226, KSU1_D0227, monoxide dehydrogenase/acetyl-CoA synthase, multienzyme carbon monoxide dehydrogenase complex, multienzyme CO dehydrogenase/acetyl-CoA synthase complex

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.169 CO-methylating acetyl-CoA synthase

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Results	in table
5	Activating Compound
2659	AA Sequence
2	CAS Registry Number
8	Cloned(Commentary)
3	Cofactor
6	Crystallization (Commentary)
1	Expression
23	General Information
2	General Stability
21	Inhibitors
1	kcat/KM [mM/s]
2	Ki Value [mM]
11	KM Value [mM]
1	Localization
62	Metals/Ions
11	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
60	Organism
7	Pathway
48	PDB ID
13	pH Optimum
11	Protein Variants
7	Purification (Commentary)
32	Reaction
1	Reaction Type
47	Reference
1	Renatured (Commentary)
1	Source Tissue
7	Specific Activity [micromol/min/mg]
66	Substrates and Products (Substrate)
13	Subunits
42	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
5	Turnover Number [1/s]

Cloned

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Cloned on EC 2.3.1.169 - CO-methylating acetyl-CoA synthase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

expression in Escherichia coli

2 entries

expression of a 49 kDa fragment containing residues 311-729 of the intact enzyme and a C-terminal His tag, in Escherichia coli

Moorella thermoacetica

P27988

696354

expression of ACSD beta in Escherichia coli strain NM522

Methanosarcina thermophila

-

719862

expression of C-terminally His-tagged enzyme in Escherichia coli strain BL21(DE3) from a pet29a(+) vector

Moorella thermoacetica

-

714240

gene ascB, expression of full-length protein, designated ACSCh732 amino acids, and as a form lacking the 317-amino acid N-terminal domain, designated ACSChDELTAN, 415 amino acids, in Escherichia coli strain NM522

Carboxydothermus hydrogenoformans

-

719862

the gene has been cloned into Escherichia coli and found to be within an 11 kb gene cluster, recombinant enzyme is inactive

Moorella thermoacetica

-

644851

two putative operons encoding CODH/ACS, designated cdh1 (ma1016-ma1011) and cdh2 (ma3860-ma3865), both encoding bona fide CODH/ACS isoforms, as well as cdhA3 (ma4399), isogenes organisation, expression of the Cdh2-encoding genes is generally higher than that of genes encoding Cdh1, expression of cdh1, cdh2, and cdhA1 in Escherichia coli

Methanosarcina acetivorans

-

719744

expression in Escherichia coli

Clostridioides difficile

-

728242

expression in Escherichia coli

Moorella thermoacetica

P27988

687803