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2.3.1.169: CO-methylating acetyl-CoA synthase

This is an abbreviated version!
For detailed information about CO-methylating acetyl-CoA synthase, go to the full flat file.

Word Map on EC 2.3.1.169

Reaction

acetyl-CoA
+
a [Co(I) corrinoid Fe-S protein]
=
CO
 +
CoA
 +
a [methyl-Co(III) corrinoid Fe-S protein]

Synonyms

ACDS multienzyme complex, acetyl-CoA decarbonylase/synthase multienzyme complex, acetyl-CoA decarboxylase/synthase, Acetyl-CoA synthase, Acetyl-coenzyme A synthase, acetyl-coenzyme A synthase/carbon monoxide dehydrogenase, ACS/CODH, ACSCh, Carbon monoxide dehydrogenase, carbon monoxide dehydrogenase-corrinoid enzyme complex, carbon monoxide dehydrogenase/acetyl coenzyme A synthase, carbon monoxide dehydrogenase/acetyl-CoA synthase, carbon monoxide dehydrogenase/acetyl-coenzyme A synthase, CDH1, Cdh2, CO dehydrogenase, CO dehydrogenase enzyme complex, CO dehydrogenase/acetyl CoA synthase, CO dehydrogenase/acetyl coenzyme A synthase, CO dehydrogenase/acetyl-CoA synthase, CODH, CODH/ACS, CODH/ASC, KSU1_D0226, KSU1_D0227, monoxide dehydrogenase/acetyl-CoA synthase, multienzyme carbon monoxide dehydrogenase complex, multienzyme CO dehydrogenase/acetyl-CoA synthase complex

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.169 CO-methylating acetyl-CoA synthase

Inhibitors

Inhibitors on EC 2.3.1.169 - CO-methylating acetyl-CoA synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
1 mM, complete inhibition. 1,10-Phenanthroline additionally has inhibitory effects on growth of Peptoclostridium difficile
2,2-dipyridyl
-
1 mM, complete inhibition. 2,2-Dipyridyl additionally has inhibitory effects on growth of Peptoclostridium difficile
5,5'dithiobis-(2-nitrobenzoic acid)
-
inhibits the acetyl-CoA/CO exchange reaction
CN-
-
inhibitor on the CoA/acetyl-CoA exchange, 98% inhibition at 1.2 mM
CO2
-
inhibitor on the CoA/acetyl-CoA exchange
CoA
-
at concentration above 10 mM, 50% inhibition of acetyl-CoA synthesis from methyl iodide at 15 mM
dephospho-CoA
-
inhibitor on the CoA/acetyl-CoA exchange, 75% inhibition at 0.44 mM
desulfo-CoA
-
inhibitor on the CoA/acetyl-CoA exchange, 30% mM at 2.1 mM
Dithionite
-
inhibits reverse methyl group transfer, when it is preincubated with methylated enzyme but not when it is preincubated with Co+-iron-sulfur protein
Fe2+
-
in cofactor ferredoxin(II), which harbors two [4Fe-4S] clusters
Mersalyl acid
-
inhibits the acetyl-CoA/CO exchange reaction
methyl iodide
-
inhibits the acetyl-CoA/CO exchange reaction
N2O
-
inhibitor on the CoA/acetyl-CoA exchange
Sodium dithionite
-
inhibits the acetyl-CoA/CO exchange reaction
Ti3+-citrate
-
inhibits reverse methyl group transfer, when it is preincubated with methylated enzyme but not when it is preincubated with Co+-iron-sulfur protein
additional information
-
no inhibition of the exchange reaction by methyl- and phenylglyoxal, and butanedione
-