2.3.1.179: beta-ketoacyl-[acyl-carrier-protein] synthase II
This is an abbreviated version!
For detailed information about beta-ketoacyl-[acyl-carrier-protein] synthase II, go to the full flat file.
Word Map on EC 2.3.1.179
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2.3.1.179
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cerulenin
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malonyl-acp
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acyl-acps
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drug development
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cis-vaccenic
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stearoyl-acp
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thiolactomycin
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fasii
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claisen
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biotechnology
- 2.3.1.179
- cerulenin
- malonyl-acp
- acyl-acps
- drug development
-
cis-vaccenic
- stearoyl-acp
- thiolactomycin
- fasii
-
claisen
- biotechnology
Reaction
Synonyms
3-ketoacyl acyl synthase II, 3-ketoacyl-ACP synthase, 3-ketoacyl-ACP synthase 2, 3-ketoacyl-ACP synthase II, 3-oxoacyl-(acylcarrier protein) synthase II, 3-oxoacyl-ACP synthase II, B-ketoacyl-ACP synthase II, beta-ketoacyl ACP-synthase II, beta-ketoacyl acyl carrier protein synthase II, beta-ketoacyl acyl-carrier protein synthase II, beta-ketoacyl synthase II, beta-ketoacyl-(acyl-carrier-protein) synthase II, beta-ketoacyl-ACP synthase FabF3, beta-ketoacyl-ACP synthase II, beta-ketoacyl-acyl carrier protein synthase I/II, beta-ketoacyl-acyl carrier protein synthase II, beta-ketoacyl-acyl carrier protein synthases II, beta-ketoacyl-acyl carrier protein synthetase II, beta-ketoacyl-acyl-carrier protein synthase II, beta-ketoacyl-acyl-carrier-protein synthase II, beta-ketoacyl-[ACP] synthase II, beta-ketoacyl-[ACP] synthase-II, beta-ketoacyl-[acyl carrier protein (ACP)] synthase II, beta-ketoacyl-[acyl-carrier protein (ACP)] synthase II, beta-ketoacyl-[acyl-carrier-protein] synthase II, FabB, FabB/F, FabF, FabF elongation condensing enzyme, FabF of type II fatty acid biosynthesis, FabF1, FASII, fatty acid synthesis type II, KAS II, KAS-II, KAS2, KASII
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Reference on EC 2.3.1.179 - beta-ketoacyl-[acyl-carrier-protein] synthase II
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Garwin, J.L.; Klages, A.L.; Cronan, J.E.
Structural, enzymatic, and genetic studies of beta-ketoacyl-acyl carrier protein synthases I and II of Escherichia coli
J. Biol. Chem.
255
11949-11956
1980
Escherichia coli (P0AAI5)
D'Agnolo, G.; Rosenfeld, I.S.; Vagelos, P.R.
Multiple forms of beta-ketoacyl-acyl carrier protein synthetase in Escherichia coli
J. Biol. Chem.
250
5289-5294
1975
Escherichia coli (P0AAI5)
MacKintosh, R.W.; Hardie, D.G.; Slabas, A.R.
beta-Ketoacyl-acyl-carrier protein synthase from developing seeds of oilseed rape (Brassica napus)
Biochem. Soc. Trans.
17
686-687
1989
Brassica napus
-
Shimakata, T.; Stumpf, P.L.
Isolation and function of spinach leaf beta-ketoacyl-[acyl-carrier-protein] synthases
Proc. Natl. Acad. Sci. USA
79
5808-5812
1982
Spinacia oleracea
Domergue, F.; Post-Beittenmiller, D.
Biochemical characterization of 3-ketoacyl-acyl carrier protein synthase II from leek epidermis
Biochem. Soc. Trans.
28
610-613
2000
Allium ampeloprasum
Moche, M.; Dehesh, K.; Edwards, P.; Lindqvist, Y.
The crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Synechocystis sp. at 1.54.ANG. resolution and its relationship to other condensing enzymes
J. Mol. Biol.
305
491-503
2001
Synechocystis sp. (P73283), Synechocystis sp.
Price, A.C.; Rock, C.O.; White, S.W.
The 1.3-Angstrom-resolution crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Streptococcus pneumoniae
J. Bacteriol.
185
4136-4143
2003
Streptococcus pneumoniae
McGuire, K.A.; McGuire, J.N.; Von Wettstein-Knowles, P.
Acyl carrier protein (ACP) inhibition and other differences between beta-ketoacyl synthase (KAS) I and II
Biochem. Soc. Trans.
28
607-610
2000
Escherichia coli (P0AAI5), Escherichia coli
Huang, W.; Jia, J.; Edwards, P.; Dehesh, K.; Schneider, G.; Lindqvist, Y.
Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes
EMBO J.
17
1183-1191
1998
Escherichia coli (P0AAI5), Escherichia coli
Jackowski, S.; Rock, C.O.
Altered molecular form of acyl carrier protein associated with beta-ketoacyl-acyl carrier protein synthase II (fabF) mutants
J. Bacteriol.
169
1469-1473
1987
Escherichia coli
Magnuson, K.; Carey, M.R.; Cronan, J.E.
The putative fabJ gene of Escherichia coli fatty acid synthesis is the fabF gene
J. bacteriol.
177
3593-3595
1995
Escherichia coli (P0AAI5), Escherichia coli
Garwin, J.L.; Klages, A.L.; Cronan, J.E., Jr.
beta-Ketoacyl-acyl carrier protein synthase II of Escherichia coli. Evidence for function in the thermal regulation of fatty acid synthesis
J. Biol. Chem.
255
3263-3265
1980
Escherichia coli (P0AAI5), Escherichia coli
Martz, F.; Kiviniemi, S.; Palva, T.E.; Sutinen, M.L.
Contribution of omega-3 fatty acid desaturase and 3-ketoacyl-ACP synthase II (KASII) genes in the modulation of glycerolipid fatty acid composition during cold acclimation in birch leaves
J. Exp. Bot.
57
897-909
2006
Betula pendula
Zhang, Y.; Hurlbert, J.; White, S.W.; Rock, C.O.
Roles of the active site water, histidine 303, and phenylalanine 396 in the catalytic mechanism of the elongation condensing enzyme of Streptococcus pneumoniae
J. Biol. Chem.
281
17390-17399
2006
Streptococcus pneumoniae
Wang, J.; Soisson, S.M.; Young, K.; Shoop, W.; Kodali, S.; Galgoci, A.; Painter, R.; Parthasarathy, G.; Tang, Y.S.; Cummings, R.; Ha, S.; Dorso, K.; Motyl, M.; Jayasuriya, H.; Ondeyka, J.; Herath, K.; Zhang, C.; Hernandez, L.; Allocco, J.; Basilio, A.; Tormo, J.R.; Genilloud, O.; Vicente, F.; Pelaez, F.
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
Nature
441
358-361
2006
Staphylococcus aureus, Escherichia coli (P0AAI5)
Pidkowich, M.S.; Nguyen, H.T.; Heilmann, I.; Ischebeck, T.; Shanklin, J.
Modulating seed beta-ketoacyl-acyl carrier protein synthase II level converts the composition of a temperate seed oil to that of a palm-like tropical oil
Proc. Natl. Acad. Sci. USA
104
4742-4747
2007
Arabidopsis thaliana, Arabidopsis sp.
Wang, J.; Kodali, S.; Lee, S.H.; Galgoci, A.; Painter, R.; Dorso, K.; Racine, F.; Motyl, M.; Hernandez, L.; Tinney, E.; Colletti, S.L.; Herath, K.; Cummings, R.; Salazar, O.; Gonzalez, I.; Basilio, A.; Vicente, F.; Genilloud, O.; Pelaez, F.; Jayasuriya, H.; Young, K.; Cully, D.F.; Singh, S.B.
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties
Proc. Natl. Acad. Sci. USA
104
7612-7616
2007
Staphylococcus aureus
Parthasarathy, G.; Cummings, R.; Becker, J.W.; Soisson, S.M.
Surface-entropy reduction approaches to manipulate crystal forms of beta-ketoacyl acyl carrier protein synthase II from Streptococcus pneumoniae
Acta Crystallogr. Sect. D
D64
141-148
2008
Streptococcus pneumoniae (Q9FBC2), Streptococcus pneumoniae
Morgan-Kiss, R.M.; Cronan, J.E.
The Lactococcus lactis FabF fatty acid synthetic enzyme can functionally replace both the FabB and FabF proteins of Escherichia coli and the FabH protein of Lactococcus lactis
Arch. Microbiol.
190
427-437
2008
Lactococcus lactis
Parthasarathy, G.; Cummings, R.; Becker, J.W.; Soisson, S.M.
Surface-entropy reduction approaches to manipulate crystal forms of beta-ketoacyl acyl carrier protein synthase II from Streptococcus pneumoniae
Acta Crystallogr. Sect. D
64
141-148
2008
Streptococcus pneumoniae (Q9FBC2), Streptococcus pneumoniae
Zhu, L.; Cheng, J.; Luo, B.; Feng, S.; Lin, J.; Wang, S.; Cronan, J.E.; Wang, H.
Functions of the Clostridium acetobutylicium FabF and FabZ proteins in unsaturated fatty acid biosynthesis
BMC Microbiol.
9
119
2009
Clostridium acetobutylicum
Hakozaki, H.; Park, J.I.; Endo, M.; Takada, Y.; Kazama, T.; Takeda, Y.; Suzuki, G.; Kawagishi-Kobayashi, M.; Watanabe, M.
Expression and developmental function of the 3-ketoacyl-ACP synthase2 gene in Arabidopsis thaliana
Genes Genet. Syst.
83
143-152
2008
Arabidopsis thaliana (Q9C9P4), Arabidopsis thaliana
Sharma, S.; Sharma, S.K.; Surolia, N.; Surolia, A.
beta-Ketoacyl-ACP synthase I/II from Plasmodium falciparum (PfFabB/F) - is it B or F?
IUBMB Life
61
658-662
2009
Plasmodium falciparum
Benisty, R.; Cohen, A.Y.; Feldman, A.; Cohen, Z.; Porat, N.
Endogenous H2O2 produced by Streptococcus pneumoniae controls FabF activity
Biochim. Biophys. Acta
1801
1098-1104
2010
Streptococcus pneumoniae
Borgaro, J.; Chang, A.; MacHutta, C.; Zhang, X.; Tonge, P.
Substrate recognition by beta-ketoacyl-ACP synthases
Biochemistry
50
10678-10686
2011
Escherichia coli
Lewis, R.A.; Nunns, L.; Thirlway, J.; Carroll, K.; Smith, C.P.; Micklefield, J.
Active site modification of the beta-ketoacyl-ACP synthase FabF3 of Streptomyces coelicolor affects the fatty acid chain length of the CDA lipopeptides
Chem. Commun. (Camb. )
47
1860-1862
2011
Streptomyces coelicolor
Feng, Z.; Chakraborty, D.; Dewell, S.B.; Reddy, B.V.; Brady, S.F.
Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesis
J. Am. Chem. Soc.
134
2981-2987
2012
Enterococcus faecalis, Staphylococcus aureus, Enterococcus faecalis OG1RF
Ramli, U.; Embi, M.; Omar, O.; Sambanthamurthi, R.
Biochemical studies and purification of oil palm (Elaeis guineensis Jacq.) beta-ketoacyl-acyl-carrier-protein (ACP) synthase (KAS) II enzyme
J. Oil Palm Res.
24
1432-1441
2012
Elaeis guineensis, Elaeis guineensis Jacq.
-
Wei, Q.; Li, J.; Zhang, L.; Wu, P.; Chen, Y.; Li, M.; Jiang, H.; Wu, G.
Cloning and characterization of a beta-ketoacyl-acyl carrier protein synthase II from Jatropha curcas
J. Plant Physiol.
169
816-824
2012
Jatropha curcas (Q000L2), Jatropha curcas
Teh, O.K.; Ramli, U.S.
Characterization of a KCS-like KASII from Jessenia bataua that elongates saturated and monounsaturated stearic acids in Arabidopsis thaliana
Mol. Biotechnol.
48
97-108
2011
Oenocarpus bataua
Baum, B.; Lecker, L.S.; Zoltner, M.; Jaenicke, E.; Schnell, R.; Hunter, W.N.; Brenk, R.
Structures of Pseudomonas aeruginosa beta-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crysta
Acta Crystallogr. Sect. F
71
1020-1026
2015
Pseudomonas aeruginosa (G3XDA2)
Wang, E.; Chinni, S.; Bhore, S.J.
Three-dimensional (3D) structure prediction of the American and African oil-palms beta-ketoacyl-[ACP] synthase-II protein by comparative modelling
Bioinformation
10
130-137
2014
Elaeis oleifera (C3W5I8), Elaeis oleifera, Elaeis guineensis (Q9M604), Elaeis guineensis
Wang, Y.; Ma, S.
Recent advances in inhibitors of bacterial fatty acid synthesis type II (FASII) system enzymes as potential antibacterial agents
ChemMedChem
8
1589-1608
2013
Enterococcus faecalis, Haemophilus influenzae, Staphylococcus aureus
Bhore, S.J.; Cha, T.S.; Amelia, K.; Shah, F.H.
Insights from computational analysis of full-length beta-ketoacyl-[ACP] synthase-II cDNA isolated from American and African oil palms
J. Nat. Sci. Biol. Med.
5
73-81
2014
Elaeis oleifera (C3W5I8), Elaeis oleifera, Elaeis guineensis (Q9M604), Elaeis guineensis
Aslan, S.; Hofvander, P.; Dutta, P.; Sitbon, F.; Sun, C.
Transient silencing of the KASII genes is feasible in Nicotiana benthamiana for metabolic engineering of wax ester composition
Sci. Rep.
5
11213
2015
Nicotiana benthamiana, Arabidopsis thaliana (Q9C9P4)
Nanson, J.D.; Himiari, Z.; Swarbrick, C.M.; Forwood, J.K.
Structural characterisation of the beta-ketoacyl-acyl carrier protein synthases, FabF and FabH, of Yersinia pestis
Sci. Rep.
5
14797
2015
Yersinia pestis (Q7CJ22)
Mojica, S.A.; Salin, O.; Bastidas, R.J.; Sunduru, N.; Hedenstroem, M.; Andersson, C.D.; Nunez-Otero, C.; Engstroem, P.; Valdivia, R.H.; Elofsson, M.; Gylfe, A.
N-acylated derivatives of sulfamethoxazole block chlamydia fatty acid synthesis and interact with FabF
Antimicrob. Agents Chemother.
61
e00716-17
2017
Chlamydia trachomatis (A0A0H3MGB3), Chlamydia trachomatis 434/Bu (A0A0H3MGB3)
Morvan, C.; Halpern, D.; Kenanian, G.; Pathania, A.; Anba-Mondoloni, J.; Lamberet, G.; Gruss, A.; Gloux, K.
The Staphylococcus aureus FASII bypass escape route from FASII inhibitors
Biochimie
141
40-46
2017
Staphylococcus aureus
Sabbagh, G.; Berakdar, N.
Molecular docking study of flavonoid compounds as inhibitors of beta-ketoacyl acyl carrier protein synthase II (KAS II) of Pseudomonas aeruginosa
Int. J. Pharm. Pharm. Sci.
8
52-61
2016
Pseudomonas aeruginosa (G3XDA2), Pseudomonas aeruginosa ATCC 15692 (G3XDA2)
-
Li, M.; Meng, Q.; Fu, H.; Luo, Q.; Gao, H.
Suppression of fabB mutation by fabF1 is mediated by transcription read-through in Shewanella oneidensis
J. Bacteriol.
198
3060-3069
2016
Shewanella oneidensis, Shewanella oneidensis ATCC 700550
Cao, W.; Ma, W.; Zhang, B.; Wang, X.; Chen, K.; Li, Y.; Ouyang, P.
Improved pinocembrin production in Escherichia coli by engineering fatty acid synthesis
J. Ind. Microbiol. Biotechnol.
43
557-566
2016
Escherichia coli (P0AAI5)
Li, K.; Li, L.; Xu, Y.
Crystal structure determination of a chimeric FabF by XRD
Nucl. Sci. Tech.
28
123
2017
Streptomyces albus, Streptomyces platensis, Streptomyces albus J1074
-
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