Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.3.1.180: beta-ketoacyl-[acyl-carrier-protein] synthase III

This is an abbreviated version!
For detailed information about beta-ketoacyl-[acyl-carrier-protein] synthase III, go to the full flat file.

Word Map on EC 2.3.1.180

Reaction

acetyl-CoA
+
a malonyl-[acyl-carrier protein]
=
an acetoacetyl-[acyl-carrier protein]
 +
CoA
 +
CO2

Synonyms

3-ketoacyl ACP synthase III, 3-ketoacyl acyl carrier protein synthase III, 3-ketoacyl carrier protein synthase III, 3-ketoacyl-(acyl carrier protein) synthase IIIA, 3-ketoacyl-(acyl carrier protein) synthase IIIB, 3-ketoacyl-ACP synthase III, 3-ketoacyl-acyl carrier protein synthase III, 3-ketoacyl-acyl-carrier protein synthase III, 3-oxoacyl-ACP synthase III, 3-oxoacyl-acyl carrier protein synthase III, 3-oxoacyl-[acyl-carrier-protein] synthase III, 3-oxoacyl:ACP synthase III, AbyA1, acetoacetyl-ACP synthase, acetyl-CoA:ACP transacylase, acetyl-CoA:malonyl-[acyl-carrier-protein] C-acyltransferase, ACO synthase III, ACP synthase III, AknE2, AlnI, AsuC3, AsuC4, AviN, BenQ, beta-ketoacyl (acyl carrier protein) synthase III, beta-ketoacyl acyl carrier protein synthase III, beta-ketoacyl acyl-carrier protein synthase III, beta-ketoacyl-(ACP) synthase III, beta-ketoacyl-(acyl-carrier-protein) synthase III, beta-ketoacyl-ACP III, beta-ketoacyl-ACP synthase, beta-ketoacyl-ACP synthase III, beta-ketoacyl-ACP synthase III-like protein, beta-ketoacyl-ACP-synthase III, beta-ketoacyl-acyl carrier protein (ACP) synthase III, beta-ketoacyl-acyl carrier protein synthase III, beta-ketoacyl-acyl carrier protein synthase-III, beta-ketoacyl-[acyl-carrier protein (ACP)] synthase III, beta-ketoacyl-[acyl-carrier-protein] synthase III, beta-ketoacyl:acyl carrier protein synthase III, beta-ketoacylacylcarrier protein synthase III, beta-ketobutyryl-ACP synthase, BomK, CalO4, CerJ, ChlB3, ChlB6, CorB, DarB, DpsC, ecFabH, ecKAS III, efFabH, EsmD1, EvrI, FabH, FabH1, FabH2, FabH3, FabHA, FabHB, fatty acid biosynthesis, enzyme H, fatty acid synthase type II condensing enzyme, FdmS, FrenI/FrnI, HedS, hiFabH, initiation ketosynthase, JcKAS III, KAS III, KAS III-like protein, KAS IIIA, KAS IIIB, KAS-III, KAS3a, KAS3b, KASIII, KijB, LstA, LstAB, LstB, mtFabH, MxnB, nmFabH, NphT7, NzsF, paFabH, PpyS, PqsBC, PqsD, PtmR, RedP, RevR, RkD, saFabH, SalQ/Orf12, short-chain condensing enzyme, spFabH, spyFabH, SsfN, TcsB, ThgI, TiaF, Tmn15, [acyl-carrier-protein] synthase III

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.180 beta-ketoacyl-[acyl-carrier-protein] synthase III

Inhibitors

Inhibitors on EC 2.3.1.180 - beta-ketoacyl-[acyl-carrier-protein] synthase III

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2R)-5-hydroxy-2,4-dimethyl-2-[(1E)-2-methylbuta-1,3-dien-1-yl]thiophen-3(2H)-one
-
-
(5R)-4-hydroxy-3,5-dimethyl-5-tetradecylthiophen-2(5H)-one
-
-
(5R)-4-hydroxy-3,5-dimethyl-5-tridecylthiophen-2(5H)-one
-
-
(5R)-4-hydroxy-5-[[4'-(hydroxymethyl)biphenyl-4-yl]methyl]-3,5-dimethylthiophen-2(5H)-one
-
-
(5R)-5-dodecyl-4-hydroxy-3,5-dimethylthiophen-2(5H)-one
-
-
(5R)-5-[3-(4-acetyl-3-hydroxyphenyl)prop-2-yn-1-yl]-4-hydroxy-3,5-dimethylthiophen-2(5H)-one
-
-
(5R)-5-[3-(4-acetylphenyl)prop-2-yn-1-yl]-4-hydroxy-3,5-dimethylthiophen-2(5H)-one
-
-
(9E)-N-[(4-aminophenyl)sulfonyl]undec-9-enamide
-
-
(E) -N'-((E)-3-(2-methoxyphenyl)al lyl idene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
(E) -N'-((E)-3-(2-Ni trophenyl)allylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
(E) -N'-((E)-3-(4-bromophenyl)al lyl idene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(2,4-dichlorophenyl)acrylate
-
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(2-bromophenyl)acrylate
-
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(3-bromophenyl)acrylate
-
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(3-fluorophenyl)acrylate
-
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-(benzyloxy)phenyl)acrylate
-
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-(dimethylamino)phenyl)acrylate
-
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-bromophenyl)acrylate
-
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-chlorophenyl)acrylate
-
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(biphenyl-4-yl)acrylate
-
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(naphthalen-1-yl)acrylate
-
-
(E)-1-(6-chloropyridin-3-yl)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methylene)methanamine
-
(E)-1-(6-chloropyridin-3-yl)-N-((3,4-dihydro-2Hbenzo[b][1,4]dioxepin-7-yl)methylene)methanamine
-
(E)-2-(2,6-dimethylphenyl)ethenyl phenyl sulfone
-
-
(E)-4-chloro-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methylene)pyridin-2-amine
-
(E)-5-chloro-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methylene)pyridin-2-amine
-
(E)-6-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methyleneamino)nicotinonitrile
-
(E)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-bromophenylamino)acrylate
-
-
(E)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-isopropylphenylamino)acrylate
-
-
(E)-N'-((E)-3-(2-fluorophenyl)allyl-idene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
-
(E)-N'-((E)-3-(2-methoxyphenyl)allyl-idene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
-
(E)-N'-((E)-3-(2-methoxyphenyl)allylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
(E)-N'-((E)-3-(2-ni trophenyl)allyl-idene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
(E)-N'-((E)-3-(2-nitrophenyl)allylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
(E)-N'-((E)-3-(4-bromophenyl)allylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
(E)-N'-((E)-3-phenylallylidene)-2,3-dihydrobenzo[b][1,4]-dioxine-2-carbohydrazide
(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-3-methylpyridin-2-amine
-
(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-4-methylpyridin-2-amine
-
(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-5-(trifluoromethyl)pyridin-2-amine
-
(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)pyridin-3-amine
-
(E)-tert-butyl 4-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methyleneamino)piperidine-1-carboxylate
-
(Z)-1-methyl-2-phenylethenyl phenyl sulfone
-
-
(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(2,4-dibromophenylamino)acrylate
-
-
(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(2-chlorophenylamino)acrylate
-
-
(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-bromophenylamino)acrylate
-
-
(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-fluorophenylamino)acrylate
-
-
(Z)-ethyl 3-(p-toluidino)-2-(4-(benzyloxy)phenyl)acrylate
-
-
1,1'-disulfanediyldinaphthalen-2-ol
-
-
1-(2,6-dichlorobenzyl)-5-[(3-methoxybenzyl)oxy]-1H-indole-2-carboxylic acid
-
1-(2,6-dichlorobenzyl)-5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid
-
1-(2,6-dichlorobenzyl)-5-[[4-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid
an indole derivative, inhibits FabH by 98% at 0.0375 mM
1-(2-bromobenzyl)-5-[(3-methoxybenzyl)oxy]-1H-indole-2-carboxylic acid
-
1-(2-chlorophenyl)-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea
-
-
1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl (2E)-3-(biphenyl-4-yl)prop-2-enoate
-
1-(3,5-dibromo-2-hydroxybenzyl)-1-(4-fluorophenyl)-3-phenylurea
-
-
1-(4-carboxybenzyl)-5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid
an indole derivative, inhibits FabH by 80% at 0.040 mM
1-(4-carboxybutyl)-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid
1-(4-chlorophenyl)-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea
-
-
1-(4-[(E)-[3-(benzyloxy)benzylidene]amino]phenyl)-3-phenylthiourea
molecular docking indicates that the compound has one hydrogen bonding interaction with Thr 81 of Escherichia coli FabH
1-(5-bromo-2-hydroxybenzyl)-1-(2-bromophenyl)-3-phenylurea
-
-
1-(5-bromo-2-hydroxybenzyl)-1-(2-chlorophenyl)-3-phenylurea
-
-
1-(5-bromo-2-hydroxybenzyl)-1-(2-fluorophenyl)-3-phenylurea
-
-
1-(5-bromo-2-hydroxybenzyl)-1-(4-bromophenyl)-3-phenylurea
-
-
1-(5-bromo-2-hydroxybenzyl)-1-(4-chlorophenyl)-3-phenylurea
1-(5-bromo-2-hydroxybenzyl)-1-(4-fluorophenyl)-3-phenylurea
-
-
1-(5-carboxypentyl)-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid
-
1-(5-carboxypentyl)-5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid
-
1-cyclohexyl-N-(2'-hydroxy-1,1':3',1''-terphenyl-5'-yl)-5-oxopyrrolidine-3-carboxamide
-
1-phenylethyl (2Z)-3-[(4,5-dimethyl-2-oxido-1,3,2-dioxaphospholan-2-yl)oxy]but-2-enoate
-
-
1-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid
1-[3,5-bis(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
-
1-[3-(4-methoxyphenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
-
1-[3-(4-methoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
-
1-[4-(trifluoromethyl)benzyl]-5-[[4-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid
-
1-[5-(2-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
-
1-[5-(4-bromophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
-
1-[5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
-
1-[5-(4-fluorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
10,10-dimethyl-7-(2-nitrophenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
-
-
10,10-dimethyl-7-(3-chlorophenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
-
-
10,10-dimethyl-7-(3-nitrophenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
-
-
10,10-dimethyl-7-(4-chlorophenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
-
-
10,10-dimethyl-7-(4-hydroxy-3-methoxyphenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
-
-
10,10-dimethyl-7-(4-hydroxyphenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
-
-
10,10-dimethyl-7-(4-nitrophenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
-
-
10,10-dimethyl-7-(naphthalen-2-yl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
-
-
10,10-dimethyl-7-(thiophen-2-yl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
-
-
14-bromo-3-diethylsulfamoyl-5-methylbenzoic acid
-
-
2,2'-(benzene-1,3-diyldisulfonyl)dibenzene-1,4-diol
-
-
2,2'-disulfanediylbis(4-chlorophenol)
-
-
2,2'-disulfanediyldiphenol
-
-
2,2'-sulfanediylbis(4-chlorophenol)
-
-
2,2'-trisulfane-1,3-diylbis(4-chlorophenol)
-
-
2,4-dibromo-6-[(E)-(2-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene)methyl]phenol
-
2,4-dibromo-6-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol
-
-
2,4-dibromo-6-[(E)-[2-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]phenol
the binding model demonstrated that the phenolic hydroxy group of 40 interacts with the amino hydrogen of Asn247 of Escherichia coli FabH by hydrogen bonds
2,4-dibromo-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
-
2,4-dibromo-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
-
2,4-dichloro-6-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol
-
-
2,4-dichloro-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
-
2,4-dichloro-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
-
2,5-anhydro-3,4-dideoxy-3-[[(3-phenoxyphenyl)carbonyl]amino]-2-thiopentonic acid
2,5-dichloro-4-nitro-N-[4-(trifluoromethyl)phenyl]thiophene-3-sulfonamide
-
-
2,5-dichloro-N-[4-(trifluoromethyl)phenyl]thiophene-3-sulfonamide
-
-
2-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-5-(2-methylbenzyl)-1,3,4-oxadiazole
-
-
2-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol
-
-
2-((4-bromo-3-[(diethylamino)sulfonyl]benzoyl)amino)benzoic acid
benzoylamino-benzoic acid derivative inhibitor-enzyme interaction analysis, overview
2-(2-methoxyphenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
-
-
2-(2-methoxyphenyl)-5-[(2-methyl-5-nitro-1H-imidazol-1-yl)methyl]-1,3,4-oxadiazole
-
2-(2-methyl-5-nitro-1H-imidazol-1-yl)-N'-[(E)-(3,4,5-trimethylphenyl)methylidene]acetohydrazide
-
2-(3,4-diethoxyphenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
2-(3-bromobenzoylamino)benzoic acid methyl ester
-
-
2-(3-bromophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
-
-
2-(3-bromophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
2-(3-bromophenyl)-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]acetamide
-
2-(3-chlorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
2-(3-diethylsulfamoyl-4-fluorobenzoylamino)benzoic acid
-
IC50 is 0.0084 mM
2-(3-diethylsulfamoyl-4-methoxybenzoylamino)benzoic acid
-
IC50 is 0.0114 mM
2-(3-diethylsulfamoyl-4-phenoxybenzoylamino)benzoic acid
-
IC50 is 0.0061 mM
2-(3-diethylsulfamoyl-4-piperidin-1-ylbenzoylamino)benzoic acid
-
IC50 is 0.0022 mM
2-(3-methoxyphenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
-
-
2-(3-methoxyphenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
2-(3-phenoxy-4-piperazin-1-ylbenzoylamino)benzoic acid
-
IC50 is 0.185 mM
2-(3-phenoxy-4-piperidin-1-ylbenzoylamino)benzoic acid
-
IC50 is 0.00029 mM
2-(3-phenoxy-4-pyridin-3-ylbenzoylamino)benzoic acid
-
IC50 is 0.00011 mM
2-(3-phenoxy-4-thiomorpholin-4-ylbenzoylamino)benzoic acid
-
IC50 is 0.0012 mM
2-(3-phenoxybenzoylamino)benzoic acid
-
IC50 is 0.0027 mM
2-(3-phenoxybenzoylamino)nicotinic acid
-
IC50 is above 1.0 mM
2-(3-phenoxybenzoylamino)thiophene-3-carboxylic acid
-
IC50 is 0.043 mM
2-(4-bromo-3-diethylsulfamoyl-5-methylbenzoylamino)-benzoic acid
-
IC50 is 0.16 mM
2-(4-bromo-3-diethylsulfamoylbenzoylamino)-benzoic acid
-
IC50 is 0.0016 mM
2-(4-bromo-3-phenoxybenzoylamino)-6-hydroxybenzoic acid
-
IC50 is 0.000062 mM
2-(4-bromo-3-phenoxybenzoylamino)-6-methoxybenzoic acid
-
-
2-(4-bromo-3-phenoxybenzoylamino)benzoic acid
-
IC50 is 0.0011 mM
2-(4-bromo-3-phenoxybenzoylamino)benzoic acid methyl ester
-
-
2-(4-bromophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
-
-
2-(4-bromophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
2-(4-bromophenyl)-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]acetamide
-
2-(4-chlorobenzene-1-sulfonyl)naphthalene-1,4-diol
2-(4-chlorophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
-
-
2-(4-chlorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
2-(4-cyclopentylmethoxy-3-diethylsulfamoylbenzoylamino)benzoic acid
-
IC50 is 0.0021 mM
2-(4-fluoro-3-phenoxybenzoylamino)benzoic acid
-
IC50 is 0.0038 mM
2-(4-fluoro-3-phenoxybenzoylamino)benzoic acid methyl ester
-
-
2-(4-fluorophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
-
-
2-(4-fluorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
2-(4-methylbenzene-1-sulfonyl)anthracene-1,4-diol
2-(4-methylbenzene-1-sulfonyl)naphthalene-1,4-diol
2-(4-methylbenzene-1-sulfonyl)naphthalene-1,4-dione
2-(4-morpholin-4-yl-3-phenoxybenzoylamino)benzoic acid
-
IC50 is 0.0032 mM
2-(4-propylbenzene-1-sulfonyl)naphthalene-1,4-diol
2-(benzenesulfonyl)naphthalene-1,4-diol
2-(butylsulfonyl)ethyl 4-nitrobenzoate
-
-
2-(decane-1-sulfonyl)acetamide
FAS20013
2-(methanesulfonyl)naphthalene-1,4-diol
2-(naphthalene-2-sulfonyl)naphthalene-1,4-diol
2-(tert-butylsulfonyl)-1-(2,4-dichlorophenyl)ethanone
-
-
2-([3-[(diethylamino)sulfonyl]-4-fluorobenzoyl]amino)benzoic acid
-
-
2-([3-[(diethylamino)sulfonyl]-4-methoxybenzoyl]amino)benzoic acid
-
-
2-([4-bromo-3-[(diethylamino)sulfonyl]-5-methylbenzoyl]amino)benzoic acid
-
-
2-([4-bromo-3-[(diethylamino)sulfonyl]benzoyl]amino)benzoic acid
-
-
2-([[2-(diethylsulfamoyl)biphenyl-4-yl]carbonyl]amino)benzoic acid
-
-
2-([[2-(diethylsulfamoyl)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[2-phenoxy-3'-(trifluoromethoxy)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[2-phenoxy-4'-(trifluoromethyl)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[3'-(1-methylethyl)-2-phenoxybiphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[3-(4-fluorophenoxy)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[3-(diethylsulfamoyl)-4-fluorophenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[3-(diethylsulfamoyl)-4-methoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[3-(diethylsulfamoyl)-4-phenoxyphenyl]carbonyl]amino)benzoic acid
-
-
2-([[3-(diethylsulfamoyl)-4-phenoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[3-(diethylsulfamoyl)-4-piperidin-1-ylphenyl]carbonyl]amino)benzoic acid
-
-
2-([[3-(diethylsulfamoyl)-4-piperidin-1-ylphenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[3-(pyridin-2-yloxy)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[3-phenoxy-4-(1H-pyrazol-4-yl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[4'-(methylsulfonyl)-2-phenoxybiphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[4-(3,5-dimethylpiperazin-1-yl)-3-phenoxyphenyl]carbonyl]amino)benzoic acid
-
-
2-([[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxyphenyl]carbonyl]amino)benzoic acid
2-([[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[4-(4-methylpiperazin-1-yl)-3-phenoxyphenyl]carbonyl]amino)benzoic acid
-
-
2-([[4-(cyclopentylmethoxy)-3-(diethylsulfamoyl)phenyl]carbonyl]amino)benzoic acid
-
-
2-([[4-(cyclopentylmethoxy)-3-(diethylsulfamoyl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[4-bromo-3-(diethylsulfamoyl)-5-methylphenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[4-bromo-3-(diethylsulfamoyl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-amino-5-(3-chlorophenyl)thiazole-4-carboxylic acid
MIC value is 0.125 mM
2-amino-5-methylthiazole-4-carboxylic acid
MIC value is 0.00035 mM
2-amino-6-(naphthalen-2-ylsulfonyl)quinazolin-4-ol
-
-
2-chloro-4-sulfanylphenol
-
-
2-fluoro-6-(3-phenoxybenzoylamino)benzoic acid
-
IC50 is 0.006 mM
2-fluoro-6-[(3-phenoxybenzoyl)amino]benzoic acid
-
-
2-hydroxy-4-[(phenylsulfonyl)amino]benzoic acid
-
-
2-hydroxy-6-(3-phenoxybenzoylamino)benzoic acid
-
IC50 is 0.00041 mM
2-hydroxy-6-[(2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.000004 mM
2-hydroxy-6-[(3-phenoxybenzoyl)amino]benzoic acid
-
-
2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
2-phenyl-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
2-[(2',4'-difluoro-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00016 mM
2-[(2-diethylsulfamoyl-biphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.0016 mM
2-[(2-phenoxy-3'-trifluoromethoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00047 mM
2-[(2-phenoxy-4'-trifluoromethylbiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.000096 mM
2-[(2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.000056 mM
2-[(2E)-2-[(4-bromophenyl)methylidene]hydrazino]-4-(3,4-dichlorophenyl)-1,3-thiazole
-
-
2-[(2E)-2-[(4-bromophenyl)methylidene]hydrazino]-4-(4-chlorophenyl)-1,3-thiazole
-
-
2-[(2E)-2-[(4-bromophenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
-
2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazino]-4-(3,4-dichlorophenyl)-1,3-thiazole
-
-
2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
-
2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
-
2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
-
2-[(2E)-2-[(4-methylphenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
-
2-[(3',4'-difluoro-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00033 mM
2-[(3'-chloro-4'-fluoro-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00057 mM
2-[(3'-isopropyl-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00079 mM
2-[(3-phenoxy-4-pyridin-3-ylbenzoyl)amino]benzoic acid
-
-
2-[(3-phenoxybenzoyl)amino]benzoic acid
-
-
2-[(3-phenoxybenzoyl)amino]thiophene-3-carboxylic acid
-
-
2-[(4'-chloro-3'-methyl-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00025 mM
2-[(4'-ethoxy-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00022 mM
2-[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00024 mM
2-[(4'-hydroxy-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00041 mM
2-[(4'-methanesulfonyl-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.000028 mM
2-[(4'-methyl-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00016 mM
2-[(4-aminocyclohexyl)sulfonyl]naphthalene-1,4-diol
-
-
2-[(4-aminophenyl)sulfonyl]benzene-1,4-diol
-
-
2-[(4-bromo-3-phenoxybenzoyl)amino]-6-hydroxybenzoic acid
-
-
2-[(4-bromo-3-phenoxybenzoyl)amino]benzoic acid
-
-
2-[(4-fluoro-3-phenoxybenzoyl)amino]benzoic acid
-
-
2-[(4-methylphenyl)sulfonyl]benzene-1,4-diol
-
-
2-[(4-methylphenyl)sulfonyl]naphthalene-1,4-diol
-
-
2-[([4-[(3,5-dimethylpiperazin-1-yl)methyl]-3-phenoxyphenyl]carbonyl)amino]cyclohexanecarboxylic acid
2-[([4-[(4-methylpiperazin-1-yl)methyl]-3-phenoxyphenyl]carbonyl)amino]cyclohexanecarboxylic acid
2-[3-(3,4-dichlorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
-
2-[3-(3-carboxyphenoxy)benzoylamino]benzoic acid
-
IC50 is 0.0037 mM
2-[3-(4-bromophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-(4-methoxyphenyl)-1,3-thiazole
-
-
2-[3-(4-bromophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
-
-
2-[3-(4-bromophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
-
2-[3-(4-bromophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
-
-
2-[3-(4-carboxyphenoxy)benzoylamino]benzoic acid
-
IC50 is 0.0044 mM
2-[3-(4-fluorophenoxy)benzoylamino]benzoic acid
-
IC50 is 0.005 mM
2-[3-(4-fluorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
-
2-[3-(4-fluorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
-
-
2-[3-(4-methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
-
2-[3-(4-methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
-
-
2-[3-(4-methylphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
-
2-[3-(4-methylphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
-
-
2-[3-(pyridin-4-yloxy)benzoylamino]benzoic acid
-
IC50 is 0.010 mM
2-[3-phenoxy-4-(1H-pyrazol-4-yl)benzoylamino]benzoic acid
-
IC50 is 0.022 mM
2-[4-(2,4-dinitrophenyl)-1H-pyrazol-1-yl]-4-(trifluoromethyl)pyrimidine
-
2-[4-(3,5-dimethylpiperazin-1-yl)-3-phenoxybenzoylamino]benzoic acid
-
IC50 is 0.038 mM
2-[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxybenzoylamino]benzoic acid
-
IC50 is 0.00027 mM
2-[4-(4-methylpiperazin-1-yl)-3-phenoxybenzoylamino]benzoic acid
-
IC50 is 0.025 mM
2-[4-[3-bromo-4-(hydroxymethyl)phenyl]piperazin-1-yl]-1-(5-nitrofuran-2-yl)ethanone
-
-
2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
-
2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-(4-methoxyphenyl)-1,3-thiazole
-
-
2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
-
-
2-[5-(furan-2-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[[(2',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-[[(2',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(2-hydroxy-6-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(3',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-[[(3',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(3'-chloro-4'-fluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-[[(3'-chloro-4'-fluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(3-phenoxy-4-piperazin-1-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(3-phenoxy-4-piperidin-1-ylphenyl)carbonyl]amino]benzoic acid
2-[[(3-phenoxy-4-piperidin-1-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(3-phenoxy-4-pyridin-3-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(3-phenoxy-4-thiomorpholin-4-ylphenyl)carbonyl]amino]benzoic acid
2-[[(3-phenoxy-4-thiomorpholin-4-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(3-phenoxyphenyl)carbonyl]amino]piperidine-3-carboxylic acid
2-[[(3-phenoxyphenyl)carbonyl]amino]tetrahydrothiophene-3-carboxylic acid
2-[[(4'-chloro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-[[(4'-chloro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(4'-ethoxy-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]-6-hydroxybenzoic acid
2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(4'-hydroxy-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(4'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(4-bromo-3-hydroxy-5-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(4-bromo-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(4-fluoro-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(4-hydroxy-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(4-morpholin-4-yl-3-phenoxyphenyl)carbonyl]amino]benzoic acid
-
-
2-[[(4-morpholin-4-yl-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[3-(3-carboxyphenoxy)benzoyl]amino]benzoic acid
-
-
2-[[3-(4-carboxyphenoxy)benzoyl]amino]benzoic acid
-
-
2-[[3-(4-fluorophenoxy)benzoyl]amino]benzoic acid
-
-
2-[[3-(pyridin-4-yloxy)benzoyl]amino]benzoic acid
-
-
2-[[3-phenoxy-4-(1H-pyrazol-4-yl)benzoyl]amino]benzoic acid
-
-
3,6-dihydroxyflavone
-
i.e. YKAF01
3-(1,4-dihydroxynaphthalene-2-sulfonyl)propanoic acid
3-(2-phenylethyl)-1,3-thiazolidin-2-one 1,1-dioxide
3-(2-phenylethyl)-1,3-thiazolidine-2-thione
3-(2-phenylethyl)-1lambda6,3-thiazolidine-1,1,2-trione
-
3-(3-phenoxybenzoylamino)pyridine-2-carboxylic acid
-
IC50 is 0.290 mM
3-(3-phenoxybenzoylamino)thiophene-2-carboxylic acid
-
IC50 is 0.0101 mM
3-(4-hydroxyphenyl)-1-(2,4,6-tri-hydroxyphenyl)propan-1-one
-
i.e. YKAF04, or 4,2',4',6'-tetrahydroxychalcone, or phloretin
3-(4-phenoxybenzyl)-1,3-thiazolidin-2-one
3-(4-phenoxybenzyl)-1,3-thiazolidin-2-one 1,1-dioxide
3-(4-phenoxybenzyl)-1,3-thiazolidine-2-thione
-
-
3-(biphenyl-4-ylmethyl)-1,3-thiazolidin-2-one
3-(biphenyl-4-ylmethyl)-1,3-thiazolidin-2-one 1,1-dioxide
3-(biphenyl-4-ylmethyl)-1,3-thiazolidine-2-thione
3-(pyridin-3-ylmethyl)-1,3-thiazolidin-2-one
3-(pyridin-3-ylmethyl)-1,3-thiazolidine-2-thione
3-benzyl-1,3-thiazolidin-2-one
3-benzyl-1,3-thiazolidin-2-one 1,1-dioxide
3-benzyl-1,3-thiazolidine-2-thione
3-benzyl-1lambda6,3-thiazolidine-1,1,2-trione
-
3-bromo-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
3-bromo-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide
fitting 3-bromo-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide into the active site of Escherichia coli FabH,PDB ID 3IL9
3-chloro-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
3-diethylsulfamoyl-4-fluorobenzoic acid
-
-
3-diethylsulfamoyl-4-methoxybenzoic acid
-
-
3-ethoxy-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
3-methoxy-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
3-methyl-1,3-thiazolidin-2-one 1,1-dioxide
3-methyl-1,3-thiazolidine-2-thione
3-propyl-1,3-thiazolidin-2-one 1,1-dioxide
3-propyl-1,3-thiazolidine-2-thione
3-[(1E)-N-(4-methyl-1,3-thiazol-2-yl)ethanehydrazonoyl]phenol
-
i.e. YKA3003
3-[(3-phenoxybenzoyl)amino]thiophene-2-carboxylic acid
-
-
3-[(4'-cyclopentylbiphenyl-4-yl)methyl]-1,3-thiazolidin-2-one 1,1-dioxide
3-[(4-aminophenyl)sulfonyl]-5-methylbenzene-1,2-diol
-
-
3-[(4-phenoxyphenyl)methyl]-1,3-thiazolidin-2-one
-
3-[(4-phenoxyphenyl)methyl]-1lambda6,3-thiazolidine-1,1,2-trione
-
3-[2-(3,4-dihydroxyphenyl)-1-methyl-2-oxoethyl]-6,7-dimethoxy-2-benzofuran-1(3H)-one
-
i.e. YKA3001
3-[3-[(2-carboxycyclohexyl)carbamoyl]phenoxy]benzoic acid
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidin-2-one
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidin-2-one 1,1-dioxide
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidine-2-thione
3-[[(3-phenoxyphenyl)carbonyl]amino]piperidine-2-carboxylic acid
3-[[4-(4-cyclopentylphenoxy)phenyl]methyl]-1,3-thiazolidin-2-one
-
3-[[4-(4-cyclopentylphenoxy)phenyl]methyl]-1,3-thiazolidine-2-thione
-
3-[[4-(4-cyclopentylphenoxy)phenyl]methyl]-1lambda6,3-thiazolidine-1,1,2-trione
-
4'-(2-carboxyphenylcarbamoyl)-2'-phenoxybiphenyl-4-carboxylic acid
-
IC50 is 0.0021 mM
4'-[(2-carboxycyclohexyl)carbamoyl]-2'-phenoxybiphenyl-4-carboxylic acid
4'-[(3-hydroxy-2,4-dimethyl-5-oxo-2,5-dihydrothiophen-2-yl)methyl]biphenyl-4-carboxylic acid
-
4,4'-disulfanediylbis(2,3,6-trichlorophenol)
-
-
4,4'-sulfanediyldibenzene-1,3-diol
-
-
4,4'-sulfonylbis(3-chloroaniline)
-
-
4,5-dichloro-1,2-dithiole-3-one
4,5-dichloro-3H-1,2-dithiol-3-one
4,5-dichloro-3H-1,2-dithiole-3-thione
-
-
4-(3,4-dichlorophenyl)-2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazino]-1,3-thiazole
-
-
4-(3,4-dichlorophenyl)-2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino]-1,3-thiazole
-
-
4-(3,4-dichlorophenyl)-2-[(2E)-2-[(4-methylphenyl)methylidene]hydrazino]-1,3-thiazole
-
-
4-(4-biphenyl-4-ylcyclohexyl)-1,3-thiazolidin-2-one
4-(4-biphenyl-4-ylcyclohexyl)-1,3-thiazolidine-2-thione
4-(4-chlorophenyl)-2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazino]-1,3-thiazole
-
-
4-(4-chlorophenyl)-2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazino]-1,3-thiazole
-
-
4-(4-chlorophenyl)-2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino]-1,3-thiazole
-
-
4-(4-chlorophenyl)-2-[(2E)-2-[(4-methylphenyl)methylidene]hydrazino]-1,3-thiazole
-
-
4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
-
-
4-bromo-2-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol
-
-
4-bromo-2-[(E)-[2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]phenol
-
4-bromo-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
-
4-bromo-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
-
4-bromo-3-diethylsulfamoylbenzoic acid
-
-
4-bromo-3-phenoxybenzoic acid
-
-
4-bromo-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
4-bromo-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide
-
4-chloro-2-[(4-hydroxyphenyl)sulfonyl]phenol
-
-
4-chloro-2-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol
-
-
4-chloro-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
-
4-chloro-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
-
4-chloro-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
4-fluoro-2-[(E)-[[2-(4-hydroxyphenyl)ethyl]imino]methyl]phenol
-
4-fluoro-3-phenoxybenzoic acid
-
-
4-fluoro-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
4-methylphenyl naphthalen-2-yl sulfone
-
-
4-methylphenyl phenyl sulfone
-
-
4-phenyl-5-phenylimino-[1,2,4]dithiazolidin-3-one
-
CAS-No. 5338-82-9, IC50 is 0.00078 mM
4-[(1Z)-N,2-bis(4-chlorophenyl)ethanimidoyl]benzene-1,3-diol
-
4-[(E)-(cyclohexylimino)methyl]benzene-1,3-diol
4-[(E)-[2-[5-(trifluoromethyl)pyridin-2-yl]hydrazinylidene]methyl]benzene-1,3-diol
-
4-[(Z)-(cyclohexylimino)methyl]benzene-1,3-diol
YKAs3003
4-[3-[(2-carboxycyclohexyl)carbamoyl]phenoxy]benzoic acid
5-benzyl-2-(2-bromoacetamido)thiazole-4-carboxylic acid
-
5-chloro-1,2-dithiole-3-ones
5-chloro-1,2-dithiole-3-thiones
5-chloro-4-phenyl-3H-1,2-dithiol-3-one
-
-
5-chloro-4-phenyl-[1,2]-dithiol-3-one
-
CAS-No. 2425-05-0, IC50 is 0.0019 mM
5-ethyl-4-fluoro-2-[(2-fluoropyridin-3-yl)oxy]phenol
-
5-hydroxy-2-phenyl-7-(2-(piperazin-1-yl)ethoxy)-4H-chromen-4-one
a chrysine derivative, strong inhibition with MIC of 0.00156–0.00625 mg/ml, molecular docking simulation and determination of inhibitor binding structure at the active site, overview
5-hydroxy-2-phenyl-7-(2-(piperidin-1-yl)ethoxy)-4H-chromen-4-one
-
5-hydroxy-2-phenyl-7-(2-(pyrrolidin-1-yl)ethoxy)-4H-chromen-4-one
-
5-hydroxy-2-phenyl-7-(3-(2-hydroxyethylamino)propoxy)-4H-chromen-4-one
-
5-hydroxy-2-phenyl-7-(3-(piperazin-1-yl)propoxy)-4H-chromen-4-one
-
5-hydroxy-2-phenyl-7-(3-(propylamino)propoxy)-4H-chromen-4-one
-
5-hydroxy-2-phenyl-7-[3-(pyrrolidin-1-yl)propoxy]-2,3-dihydro-4H-chromen-4-one
a strong inhibitor, interacts with Escherichia coli FabH via a hydrogen bond between its 5-hydroxy group and the amino hydrogen of Asn247 and a hydrophobic interaction between the pyrrolidine moiety at the C7 position and Asn274, Ile 156, Phe157, and Met2
5-hydroxy-7-(2-(4-methylpiperazin-1-yl)ethoxy)-2-phenyl-4H-chromen-4-one
-
5-hydroxy-7-(3-(4-methylpiperazin-1-yl)propoxy)-2-phenyl-4H-chromen-4-one
-
5-[(2,6-dichlorobenzyl)oxy]-1-(4-methoxybenzyl)-1H-indole-2-carboxylic acid
-
5-[(2,6-dichlorobenzyl)oxy]-1-[(6-methyl-1,3-benzodioxol-5-yl)methyl]-1H-indole-2-carboxylic acid
-
5-[(2,6-dichlorobenzyl)oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid
an indole derivative, inhibits FabH by 98% at 0.0375 mM
5-[(2-bromobenzyl)oxy]-1-(4-methoxybenzyl)-1H-indole-2-carboxylic acid
-
5-[(2-bromobenzyl)oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid
an indole derivative, inhibits FabH by 80% at 0.040 mM
5-[(4-methoxybenzyl)oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid
-
5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid
-
5-[[4-(hydroxyamino)phenyl]sulfonyl]-1,3-thiazol-2-amine
-
-
6-amino-2-hydroxy-2,5-dimethylhexanamide
-
-
6-[(2,6-dichlorophenyl)methoxy]-3-(phenylsulfanyl)-1H-indole-2-carboxylic acid
SB418011
7-(2-(dibutylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
7-(2-(diethylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
7-(2-(dipropylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
7-(2-(propylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
7-(3-(dibutylamino)propoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
7-(3-(diethylamino)propoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
7-(3-(dipropylamino)propoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
7-[(1E)-nonadec-1-en-1-yl]-3,4-dihydro-2H-1,5-benzodioxepine
-
acetoxyanthecotulide
-
acyl-[acyl-carrier protein]
-
mixed inhibition type, the enzyme is a target for fatty acid synthesis regulation by acyl-[acyl-carrier-protein], inhibitory potency increases with increasing chain length between C12 and C20
ampicillin
-
inhibition of the recombinant enzyme in transformed Mycobacterium bovis strain BCG in vivo
anthecotulide
-
arsenite
-
45% inhibition at 5 mM, 98% inhibition at 20 mM
benzyl (E)-2-[(4-methylphenyl)sulfanyl]ethenyl sulfone
-
-
bis(4-chlorophenyl)trisulfane
-
-
bis(4-methylphenyl)trisulfane
-
-
bis[4-(1-methylethyl)phenyl] sulfone
-
-
butyryl-[acyl-carrier protein]
-
feed-back inhibition of the enzyme via decrease in affinity for acetyl-CoA, inhibition mechanism
cerulenin
chrysine
i.e 1,5,7-dihydroxyflavone
Cinnamic acid
-
-
CoA methyldisulfide
CoA methyldisulfide shows rapid inhibition of one monomer of FabH through formation of a methyl disulfide conjugate. Reaction of the second subunit with either MeSSCoA or acetyl-CoA is much slower. In the presence of malonyl-ACP, the acylation rate of the second subunit is restored to that of the native FabH
decanoyl-CoA
-
IC50 is 0.004 mM
decanoyl-[acyl-carrier protein]
-
reversible, noncompetitive inhibition versus malonyl-[acyl-carrier-protein] and uncompetitive versus acetyl-CoA, IC50 is 0.00045 mM
decyl-CoA disulfide
-
-
diphenyl sulfide
-
-
Ethionamide
-
inhibition of the recombinant enzyme in transformed Mycobacterium bovis strain BCG in vivo
ethyl (2Z)-2-[4-(benzyloxy)phenyl]-3-[(4-methylphenyl)amino]prop-2-enoate
displays effective FabH inhibitory activity and excellent antibacterial activity against Gram-negative Escherichia coli. Binds to FabH through two interactions: a hydrogen bond between the N-H group and the side chain carbonyl group of Gly 209 and a hydro
ethyl 4-methylpyridine-3-carboxylate
-
-
hexanoyl-[acyl-carrier protein]
-
feed-back inhibition of the enzyme via decrease in affinity for acetyl-CoA, inhibition mechanism
hydroxyanthecotulide
-
isoniazid
-
inhibition of the recombinant enzyme in transformed Mycobacterium bovis strain BCG in vivo
isoxyl
-
inhibition of the recombinant enzyme in transformed Mycobacterium bovis strain BCG in vivo
kanamycin
lauroyl-ACP
feedback inhibition; feedback inhibition
methyl 2-(2-bromoacetamido)-5-(3-chlorophenyl) thiazole-4-carboxylate
-
methyl 2-(2-bromoacetamido)-5-phenylthiazole-4-carboxylate
-
methyl 2-amino-5-benzylthiazole-4-carboxylate
MIC value is 240 nM
methyl 2-amino-5-methylthiazole-4-carboxylate
MIC value is 0.093 mM
methyl 4-bromo-3-hydroxybenzoate
-
-
methyl 5-benzyl-2-(2-bromoacetamido)thiazole-4-carboxylate
-
methyl-CoA disulfide
N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine 2-carbohydrazide
-
N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
N'-[(1E,2E)-3-(2-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
N'-[(1E,2E)-3-(2-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
N'-[(1E,2E)-3-(2-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
N'-[(1E,2E)-3-phenylprop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
-
N'-[(1E,2E)-3-phenylprop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
N'-[(1E,2E)-3-phenylprop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
N'-[(E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
-
N'-[(E)-(3,5-dichloro-2-hydroxyphenyl)methylidene]-4-hydroxy-3-methoxybenzohydrazide
-
N-(3-(5-bromo-2-hydroxybenzylideneamino)propyl)-2-hydroxybenzamide
-
N-(3-chlorophenyl)benzenesulfonamide
-
-
N-(4-(4-bromophenyl)thiazol-2-yl)-2-(3-chlorophenyl)acetamid
the malonyl carboxylate forms hydrogen bonds to the backbone nitrogen of Phe304, inhibitor binding mode, overview
N-(4-phenyl-1,3-thiazol-2-yl)-5,8-dihydronaphthalene-2-carboxamide
-
N-(4-phenyl-1,3-thiazol-2-yl)benzamide
N-(4-phenyl-1,3-thiazol-2-yl)morpholine-4-carboxamide
-
N-(4-phenyl-1,3-thiazol-2-yl)naphthalene-1-carboxamide
-
N-(4-phenyl-1,3-thiazol-2-yl)naphthalene-2-carboxamide
-
N-(4-[[4-(acetylamino)phenyl]sulfonyl]phenyl)-2-hydroxybenzamide
-
-
N-ethylmaleimide
-
complete inhibition at 5 mM
N-[3,5-bis(trifluoromethyl)phenyl]-4-[[3,5-bis(trifluoromethyl)phenyl]amino]-3-nitrocyclopenta-1,3-diene-1-sulfonamide
-
-
N-[3-[(E)-(5-bromo-2-hydroxybenzylidene)amino]propyl]-2-hydroxybenzamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(3,4-diethoxyphenyl)acetamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(4-chlorophenyl)acetamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(4-fluorophenyl)acetamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-phenylacetamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-3-chlorobenzamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-3-ethoxybenzamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-3-methoxybenzamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-4-chlorobenzamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-4-fluorobenzamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-5,8-dihydronaphthalene-2-carboxamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]morpholine-4-carboxamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]naphthalene-1-carboxamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]naphthalene-2-carboxamide
-
naringenin
-
naringenin docks more strongly with efKAS III than apigenin, resulting in the intensive hydrogen bond network between naringenin and efKAS III. Only naringenin shows antibacterial activity against Enterococcus faecalis at 0.256 mg/ml
octanoyl-[acyl-carrier protein]
-
feed-back inhibition of the enzyme via decrease in affinity for acetyl-CoA, inhibition mechanism
octyl-CoA disulfide
-
-
penicillin G
platencin
platensimycin
pyridin-4-yloxybenzoic acid
-
-
rifampicin
-
inhibition of the recombinant enzyme in transformed Mycobacterium bovis strain BCG in vivo
S-[2-(4-methoxyphenyl)-2-oxoethyl] benzenesulfonothioate
-
-
SB418011
secnidazole
-
-
thiolactomycin
[4-(1,4-dihydroxynaphthalene-2-sulfonyl)phenyl]carbamic acid
additional information
-