2.3.1.180: beta-ketoacyl-[acyl-carrier-protein] synthase III

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For detailed information about beta-ketoacyl-[acyl-carrier-protein] synthase III, go to the full flat file.

Reaction

Synonyms

3-ketoacyl ACP synthase III, 3-ketoacyl acyl carrier protein synthase III, 3-ketoacyl carrier protein synthase III, 3-ketoacyl-(acyl carrier protein) synthase IIIA, 3-ketoacyl-(acyl carrier protein) synthase IIIB, 3-ketoacyl-ACP synthase III, 3-ketoacyl-acyl carrier protein synthase III, 3-ketoacyl-acyl-carrier protein synthase III, 3-oxoacyl-ACP synthase III, 3-oxoacyl-acyl carrier protein synthase III, 3-oxoacyl-[acyl-carrier-protein] synthase III, 3-oxoacyl:ACP synthase III, AbyA1, acetoacetyl-ACP synthase, acetyl-CoA:ACP transacylase, acetyl-CoA:malonyl-[acyl-carrier-protein] C-acyltransferase, ACO synthase III, ACP synthase III, AknE2, AlnI, AsuC3, AsuC4, AviN, BenQ, beta-ketoacyl (acyl carrier protein) synthase III, beta-ketoacyl acyl carrier protein synthase III, beta-ketoacyl acyl-carrier protein synthase III, beta-ketoacyl-(ACP) synthase III, beta-ketoacyl-(acyl-carrier-protein) synthase III, beta-ketoacyl-ACP III, beta-ketoacyl-ACP synthase, beta-ketoacyl-ACP synthase III, beta-ketoacyl-ACP synthase III-like protein, beta-ketoacyl-ACP-synthase III, beta-ketoacyl-acyl carrier protein (ACP) synthase III, beta-ketoacyl-acyl carrier protein synthase III, beta-ketoacyl-acyl carrier protein synthase-III, beta-ketoacyl-[acyl-carrier protein (ACP)] synthase III, beta-ketoacyl-[acyl-carrier-protein] synthase III, beta-ketoacyl:acyl carrier protein synthase III, beta-ketoacylacylcarrier protein synthase III, beta-ketobutyryl-ACP synthase, BomK, CalO4, CerJ, ChlB3, ChlB6, CorB, DarB, DpsC, ecFabH, ecKAS III, efFabH, EsmD1, EvrI, FabH, FabH1, FabH2, FabH3, FabHA, FabHB, fatty acid biosynthesis, enzyme H, fatty acid synthase type II condensing enzyme, FdmS, FrenI/FrnI, HedS, hiFabH, initiation ketosynthase, JcKAS III, KAS III, KAS III-like protein, KAS IIIA, KAS IIIB, KAS-III, KAS3a, KAS3b, KASIII, KijB, LstA, LstAB, LstB, mtFabH, MxnB, nmFabH, NphT7, NzsF, paFabH, PpyS, PqsBC, PqsD, PtmR, RedP, RevR, RkD, saFabH, SalQ/Orf12, short-chain condensing enzyme, spFabH, spyFabH, SsfN, TcsB, ThgI, TiaF, Tmn15, [acyl-carrier-protein] synthase III

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.180 beta-ketoacyl-[acyl-carrier-protein] synthase III

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Results	in table
1	Activating Compound
43375	AA Sequence
24	Application
1	CAS Registry Number
57	Cloned(Commentary)
14	Cofactor
19	Crystallization (Commentary)
2	Expression
128	General Information
1	General Stability
352	IC50 Value
932	Inhibitors
7	kcat/KM [mM/s]
2	Ki Value [mM]
31	KM Value [mM]
3	Localization
3	Metals/Ions
24	Molecular Weight [Da]
165	Natural Substrates/ Products (Substrates)
488	Organism
6	Pathway
81	PDB ID
35	pH Optimum
7	pI Value
3	Posttranslational Modification
80	Protein Variants
36	Purification (Commentary)
29	Reaction
57	Reaction Type
209	Reference
21	Source Tissue
38	Specific Activity [micromol/min/mg]
1	Storage Stability
303	Substrates and Products (Substrate)
42	Subunits
620	Synonyms
1	Systematic Name
30	Temperature Optimum [°C]
2	Temperature Stability [°C]
18	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.3.1.180 - beta-ketoacyl-[acyl-carrier-protein] synthase III

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SYSTEMATIC NAME

IUBMB Comments

acetyl-CoA:malonyl-[acyl-carrier protein] C-acyltransferase

The enzyme is responsible for initiating straight-chain fatty acid biosynthesis by the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria. In contrast to EC 2.3.1.41, beta-ketoacyl-[acyl-carrier-protein] synthase I, and EC 2.3.1.179, beta-ketoacyl-[acyl-carrier-protein] synthase II, this enzyme specifically uses short-chain acyl-CoA thioesters (preferably acetyl-CoA) rather than acyl-[acp] as its substrate [1]. The enzyme can also catalyse the reaction of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, but to a much lesser extent [1]. The enzymes from some organisms (e.g. the Gram-positive bacterium Streptococcus pneumoniae) can accept branched-chain acyl-CoAs in addition to acetyl-CoA [5] (cf. EC 2.3.1.300, branched-chain beta-ketoacyl-[acyl-carrier-protein] synthase).