2.3.1.181: lipoyl(octanoyl) transferase

This is an abbreviated version!
For detailed information about lipoyl(octanoyl) transferase, go to the full flat file.

Reaction

Synonyms

ACP: GcvH octanoyltransferase, ACP:protein-N-octanoyltransferase, At1g47578, At4G31050, AtLIP2p2, bLT, LIP2, LIP2P1, Lip2p2, LIP3, LipB, LipB octanoyltransferase, LipM, lipoate/octanoate transferase, lipoyl (octanoyl)-acyl carrier protein:protein transferase, lipoyl(octanoyl) transferase, lipoyl(octanoyl) transferase 2, lipoyl(octanoyl)-[acyl-carrier-protein]-protein N-lipoyltransferase, lipoyl(octanoyl)transferase, lipoyltransferase, LIPT2, octanoyl (lipoyl): N-octanoyl (lipoyl) transferase, octanoyl-acyl carrier protein:protein-N-octanoyltransferase, octanoyl-[acyl carrier protein {ACP}]:protein N-octanoyltransferase, octanoyl-[acyl carrier protein]-protein N-octanoyltransferase, octanoyl-[acyl carrier protein]:protein N-octanoyltransferase, octanoyltransferase LipM, plastidial octanoyltransferase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.181 lipoyl(octanoyl) transferase

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Results	in table
3	Activating Compound
32527	AA Sequence
2	Application
1	CAS Registry Number
9	Cloned(Commentary)
2	Crystallization (Commentary)
7	Disease/ Diagnostics
23	General Information
1	Inhibitors
3	KM Value [mM]
8	Localization
4	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
28	Organism
8	Pathway
3	pH Optimum
1	pH Range
10	Protein Variants
7	Purification (Commentary)
3	Reaction
2	Reaction Type
26	Reference
4	Source Tissue
1	Specific Activity [micromol/min/mg]
35	Substrates and Products (Substrate)
1	Subunits
56	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.3.1.181 - lipoyl(octanoyl) transferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

an octanoyl-[acyl-carrier protein] + a protein

a protein N6-(octanoyl)lysine + an [acyl-carrier protein]

2 entries

an octanoyl-[acyl-carrier protein] + glycine cleavage system protein

glycine cleavage system protein-N6-(octanoyl)lysine + an [acyl-carrier protein]

Bacillus subtilis

-

-

718134

-

-

?

octanoyl-[acyl-carrier protein] + a protein

a protein N6-(octanoyl)lysine + an [acyl-carrier protein]

2 entries

octanoyl-[acyl-carrier protein] + apo-H protein

APO H-protein N6-(octanoyl)lysine + acyl-carrier protein

Escherichia coli

-

LipB reaction represents the first committed step in the biosynthesis of the lipoyl cofactor. apo-H protein is the lipoyl bearing subunit of the glycine cleavage system

663308

-

-

?

octanoyl-[acyl-carrier protein] + protein

protein N6-(octanoyl)lysine + acyl-carrier protein

6 entries

octanoyl-[acyl-carrier protein] + protein

protein N6-(octanoyl)lysine + [acyl-carrier protein]

Bos taurus

O46419

-

688368

-

-

?

an octanoyl-[acyl-carrier protein] + a protein

a protein N6-(octanoyl)lysine + an [acyl-carrier protein]

Bacillus subtilis

-

-

718133

-

-

?

an octanoyl-[acyl-carrier protein] + a protein

a protein N6-(octanoyl)lysine + an [acyl-carrier protein]

Bacillus subtilis

-

LipM specifically modifies the glycine cleavage system protein, GcvH

718134

-

-

?

octanoyl-[acyl-carrier protein] + a protein

a protein N6-(octanoyl)lysine + an [acyl-carrier protein]

Bacillus subtilis

-

-

711217

-

-

?

octanoyl-[acyl-carrier protein] + a protein

a protein N6-(octanoyl)lysine + an [acyl-carrier protein]

Escherichia coli

-

LipB (EC 2.3.11.181) is responsible for octanoylation of the E2 components of 2-oxoacid dehydrogenases to provide the substrates of LipA (EC 2.7.7.63), an S-adenosyl-L-methionine radical enzyme that inserts two sulfur atoms into the octanoyl moiety to give the active lipoylated dehydrogenase complexes. LipB accumulates an octanoyl-enzyme intermediate with no sign of a lipoyl-enzyme intermediate

712504

-

-

?

octanoyl-[acyl-carrier protein] + protein

protein N6-(octanoyl)lysine + acyl-carrier protein

Arabidopsis thaliana

-

first committed step in the biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain) and of the 2-oxoglutarate dehydrogenase complex

663062

-

-

?

octanoyl-[acyl-carrier protein] + protein

protein N6-(octanoyl)lysine + acyl-carrier protein

Escherichia coli

-

-

661184

-

-

?

octanoyl-[acyl-carrier protein] + protein

protein N6-(octanoyl)lysine + acyl-carrier protein

Escherichia coli

-

first committed step in the biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of glycine cleavage system (H protein)

661982

-

-

?

octanoyl-[acyl-carrier protein] + protein

protein N6-(octanoyl)lysine + acyl-carrier protein

Escherichia coli

-

first committed step in the biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain)

662098

-

-

?

octanoyl-[acyl-carrier protein] + protein

protein N6-(octanoyl)lysine + acyl-carrier protein

Neurospora crassa

-

first committed step in the biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain)

662098

-

-

?

octanoyl-[acyl-carrier protein] + protein

protein N6-(octanoyl)lysine + acyl-carrier protein

Pisum sativum

-

first committed step in the biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain)

662098

-

-

?