2.3.1.181: lipoyl(octanoyl) transferase
This is an abbreviated version!
For detailed information about lipoyl(octanoyl) transferase, go to the full flat file.
Word Map on EC 2.3.1.181
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2.3.1.181
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lipoylation
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lipoic
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octanoylated
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lipoyl-amp
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2-oxoacid
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h-protein
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lipoate-dependent
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lipoate-protein
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acidosis
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octanoic
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2-ketoacid
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2-oxoadipate
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epsilon-amino
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fe-s
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alpha-keto
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swinging
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fujiwara
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nonketotic
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medicine
- 2.3.1.181
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lipoylation
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lipoic
-
octanoylated
- lipoyl-amp
- 2-oxoacid
- h-protein
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lipoate-dependent
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lipoate-protein
- acidosis
-
octanoic
-
2-ketoacid
- 2-oxoadipate
-
epsilon-amino
- fe-s
-
alpha-keto
-
swinging
-
fujiwara
-
nonketotic
- medicine
Reaction
Synonyms
ACP: GcvH octanoyltransferase, ACP:protein-N-octanoyltransferase, At1g47578, At4G31050, AtLIP2p2, bLT, LIP2, LIP2P1, Lip2p2, LIP3, LipB, LipB octanoyltransferase, LipM, lipoate/octanoate transferase, lipoyl (octanoyl)-acyl carrier protein:protein transferase, lipoyl(octanoyl) transferase, lipoyl(octanoyl) transferase 2, lipoyl(octanoyl)-[acyl-carrier-protein]-protein N-lipoyltransferase, lipoyl(octanoyl)transferase, lipoyltransferase, LIPT2, octanoyl (lipoyl): N-octanoyl (lipoyl) transferase, octanoyl-acyl carrier protein:protein-N-octanoyltransferase, octanoyl-[acyl carrier protein {ACP}]:protein N-octanoyltransferase, octanoyl-[acyl carrier protein]-protein N-octanoyltransferase, octanoyl-[acyl carrier protein]:protein N-octanoyltransferase, octanoyltransferase LipM, plastidial octanoyltransferase
ECTree
2.3.1.181 lipoyl(octanoyl) transferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.3.1.181 - lipoyl(octanoyl) transferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
an octanoyl-[acyl-carrier protein] + a protein
a protein N6-(octanoyl)lysine + an [acyl-carrier protein]
an octanoyl-[acyl-carrier protein] + GCSH protein
GCSH protein N6-(octanoyl)lysine + an [acyl-carrier protein]
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-
-
?
an octanoyl-[acyl-carrier protein] + glycine cleavage system protein
glycine cleavage system protein-N6-(octanoyl)lysine + an [acyl-carrier protein]
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-
-
-
?
lipoyl-[acyl-carrier protein] + apo-pyruvate dehydrogenase protein
?
-
-
-
-
?
octanoyl-CoA + [glycine cleavage system 3]-L-lysine
[glycine cleavage system 3]-N6-octanoyl-L-lysine + CoA
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-
-
-
?
octanoyl-CoA + [oxoglutarate dehydrogenase]-L-lysine
[oxoglutarate dehydrogenase]-N6-octanoyl-L-lysine + CoA
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-
-
-
?
octanoyl-CoA + [pyruvate dehydrogenase]-L-lysine
[pyruvate dehydrogenase]-N6-octanoyl-L-lysine + CoA
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-
-
-
?
octanoyl-[acyl-carrier protein] + a protein
a protein N6-(octanoyl)lysine + an [acyl-carrier protein]
octanoyl-[acyl-carrier protein] + alpha-ketoglutarate dehydrogenase apo-E2 domain
alpha-ketoglutarate dehydrogenase E2-domain N6-(octanoyl)lysine + acyl-carrier protein
octanoyl-[acyl-carrier protein] + apo-E2 domain
apo E2-domain protein N6-(octanoyl)lysine + acyl-carrier protein
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reaction proceeds through an acyl-enzyme intermediate
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-
?
octanoyl-[acyl-carrier protein] + apo-H protein
APO H-protein N6-(octanoyl)lysine + acyl-carrier protein
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LipB reaction represents the first committed step in the biosynthesis of the lipoyl cofactor. apo-H protein is the lipoyl bearing subunit of the glycine cleavage system
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-
?
octanoyl-[acyl-carrier protein] + apo-H protein
apo-H protein N6-(octanoyl)lysine + acyl-carrier protein
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apo-H protein is the lipoyl bearing subunit of the glycine cleavage system
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-
?
octanoyl-[acyl-carrier protein] + apo-pyruvate dehydrogenase protein
apo-pyruvate dehydrogenase protein N6-(octanoyl)lysine + acyl-carrier protein
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-
-
-
?
octanoyl-[acyl-carrier protein] + glycine dehydrogenase H-protein
glycine dehydrogenase H-protein N6-(octanoyl)lysine + acyl-carrier protein
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glycine dehydrogenase H-protein can be octanoylated both by Lip2 or by lipoate-protein ligase LPLA, EC 2.7.7.63
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?
octanoyl-[acyl-carrier protein] + protein
protein N6-(octanoyl)lysine + acyl-carrier protein
octanoyl-[acyl-carrier protein] + protein
protein N6-(octanoyl)lysine + [acyl-carrier protein]
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-
-
?
octanoyl-[acyl-carrier protein] + pyruvate dehydrogenase apo-E2 domain
pyruvate dehydrogenase apo E2-domain N6-(octanoyl)lysine + acyl-carrier protein
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-
-
?
octanoyl-[acyl-carrier protein] + [glycine cleavage system 3]-L-lysine
[glycine cleavage system 3]-N6-octanoyl-L-lysine + acyl-carrier protein
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-
in vitro reaction
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?
an octanoyl-[acyl-carrier protein] + a protein
a protein N6-(octanoyl)lysine + an [acyl-carrier protein]
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-
-
-
?
an octanoyl-[acyl-carrier protein] + a protein
a protein N6-(octanoyl)lysine + an [acyl-carrier protein]
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LipM specifically modifies the glycine cleavage system protein, GcvH
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-
?
an octanoyl-[acyl-carrier protein] + a protein
a protein N6-(octanoyl)lysine + an [acyl-carrier protein]
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acyl-enzyme intermediate mechanism
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-
?
octanoyl-[acyl-carrier protein] + a protein
a protein N6-(octanoyl)lysine + an [acyl-carrier protein]
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-
-
-
?
octanoyl-[acyl-carrier protein] + a protein
a protein N6-(octanoyl)lysine + an [acyl-carrier protein]
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the transfer of the octanoyl group from octanoyl-ACP to Bacillus subtilis GcvH occurs in a LipM-dependent manner. The LipM reaction proceeds through a thioester-linked acyl enzyme intermediate. The LipM active site nucleophile is identified as C150
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-
?
octanoyl-[acyl-carrier protein] + a protein
a protein N6-(octanoyl)lysine + an [acyl-carrier protein]
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LipB (EC 2.3.11.181) is responsible for octanoylation of the E2 components of 2-oxoacid dehydrogenases to provide the substrates of LipA (EC 2.7.7.63), an S-adenosyl-L-methionine radical enzyme that inserts two sulfur atoms into the octanoyl moiety to give the active lipoylated dehydrogenase complexes. LipB accumulates an octanoyl-enzyme intermediate with no sign of a lipoyl-enzyme intermediate
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-
?
octanoyl-[acyl-carrier protein] + a protein
a protein N6-(octanoyl)lysine + an [acyl-carrier protein]
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LipB (EC 2.3.11.181) is responsible for octanoylation of the E2 components of 2-oxoacid dehydrogenases to provide the substrates of LipA (EC 2.7.7.63), an S-adenosyl-L-methionine radical enzyme that inserts two sulfur atoms into the octanoyl moiety to give the active lipoylated dehydrogenase complexes. The binding sites for LipB reside both in the lipoyl domain and catalytic core sequences
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-
?
octanoyl-[acyl-carrier protein] + alpha-ketoglutarate dehydrogenase apo-E2 domain
alpha-ketoglutarate dehydrogenase E2-domain N6-(octanoyl)lysine + acyl-carrier protein
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-
-
?
octanoyl-[acyl-carrier protein] + alpha-ketoglutarate dehydrogenase apo-E2 domain
alpha-ketoglutarate dehydrogenase E2-domain N6-(octanoyl)lysine + acyl-carrier protein
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-
-
?
octanoyl-[acyl-carrier protein] + protein
protein N6-(octanoyl)lysine + acyl-carrier protein
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first committed step in the biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain) and of the 2-oxoglutarate dehydrogenase complex
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-
?
octanoyl-[acyl-carrier protein] + protein
protein N6-(octanoyl)lysine + acyl-carrier protein
-
-
-
-
?
octanoyl-[acyl-carrier protein] + protein
protein N6-(octanoyl)lysine + acyl-carrier protein
-
first committed step in the biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of glycine cleavage system (H protein)
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-
?
octanoyl-[acyl-carrier protein] + protein
protein N6-(octanoyl)lysine + acyl-carrier protein
-
first committed step in the biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain)
-
-
?
octanoyl-[acyl-carrier protein] + protein
protein N6-(octanoyl)lysine + acyl-carrier protein
-
-
-
-
?
octanoyl-[acyl-carrier protein] + protein
protein N6-(octanoyl)lysine + acyl-carrier protein
-
first committed step in the biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain)
-
-
?
octanoyl-[acyl-carrier protein] + protein
protein N6-(octanoyl)lysine + acyl-carrier protein
-
-
-
-
?
octanoyl-[acyl-carrier protein] + protein
protein N6-(octanoyl)lysine + acyl-carrier protein
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first committed step in the biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of pyruvate dehydrogenase (E2 domain)
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-
?
additional information
?
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pyruvate dehydrogenase E2 domain is exclusively octanoylated by lipoate-protein ligase LPLA, EC 2.7.7.63
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-
?
additional information
?
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Lip3 is unable to modify either lipoyl domains or glycine cleavage system 3 when provided with free octanoate, ATP and MgCl2
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-
?
