2.3.1.194: acetoacetyl-CoA synthase

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For detailed information about acetoacetyl-CoA synthase, go to the full flat file.

Reaction

Synonyms

AACS, Acetoacetyl-CoA synthase, Acetoacetyl-CoA synthetase, acetoacetyl-coenzyme A synthase, acetoacetyl-coenzyme A synthesizing enzyme, More, NphT7, nphT7SCL, thiolase superfamily acetoacetyl-CoA synthase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.194 acetoacetyl-CoA synthase

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Results	in table
41	AA Sequence
5	Application
7	Cloned(Commentary)
1	Expression
6	General Information
6	KM Value [mM]
4	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
9	Organism
1	pH Optimum
9	Protein Variants
1	Purification (Commentary)
2	Reaction
7	Reference
5	Source Tissue
2	Specific Activity [micromol/min/mg]
10	Substrates and Products (Substrate)
2	Subunits
21	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 2.3.1.194 - acetoacetyl-CoA synthase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2 malonyl-CoA

acetoacetyl-CoA + CoA + 2 CO2

Streptomyces sp.

-

-

706551

-

-

?

acetyl-CoA + malonyl-CoA

acetoacetyl-CoA + CoA + CO2

5 entries

acetyl-CoA + malonyl-CoA

CoA + acetoacetyl-CoA + CO2

Streptomyces sp.

-

-

706551, 714539

-

-

ir

additional information

?

-

Streptomyces sp.

-

the recombinant enzyme catalyzes a single condensation of acetyl-CoA and malonyl-CoA to give acetoacetyl-CoA and CoA. Replacement of malonyl-CoA with malonyl-(acyl carrier protein) results in loss of the condensation activity. No acetoacetyl-CoA synthesizing activity detectable through the condensation of two molecules of acetyl-CoA

706551

-

-

?

acetyl-CoA + malonyl-CoA

acetoacetyl-CoA + CoA + CO2

Streptomyces glaucescens

A0A089XE59

-

745496

-

-

ir

acetyl-CoA + malonyl-CoA

acetoacetyl-CoA + CoA + CO2

Streptomyces sp.

-

-

714539

-

-

?

acetyl-CoA + malonyl-CoA

acetoacetyl-CoA + CoA + CO2

Streptomyces sp.

-

the acetoacetyl-CoA synthesizing enzyme increases the acetoacetyl-CoA supply for mevalonate production

706551

-

-

?

acetyl-CoA + malonyl-CoA

acetoacetyl-CoA + CoA + CO2

Streptomyces sp.

-

Cys115 in NphT7 functions as a key catalytic residue for the condensation reaction. His256 functions as a catalytic residue for the decarboxylation of the extender substrate malonyl-CoA. No acetoacetyl-CoA synthesizing activity is detected through the condensation of two molecules of acetyl-CoA

706551

-

-

?

acetyl-CoA + malonyl-CoA

acetoacetyl-CoA + CoA + CO2

Streptomyces sp. CL190

D7URV0

-

745496, 746014

-

-

ir